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Base type microneedle array and preparing method thereof

A microneedle array and microneedle technology, applied in microneedles, needles, pharmaceutical formulations, etc., can solve the problems of limited drug loading, low drug utilization, and inability to control the dosage, and achieve improved drug delivery efficiency, Improve the effect of drug loading

Inactive Publication Date: 2015-11-04
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But at present, due to the limitations of the existing microneedle structure design, when the microneedle pierces the skin, it is impossible to guarantee a 100% penetration rate, that is, it is impossible to ensure that each microneedle is pierced into the skin, and the microneedle carried The drug cannot be fully absorbed into the subcutaneous area, and there is a large amount of drug residue on the pulled out microneedles, which makes the utilization rate of the drug very low, so it is impossible to control the dosage of the drug, and it is impossible to accurately calculate the amount of the drug entering the human body, so it will bring Great waste of drug use will also bring great uncertainty to the use of drugs
And due to structural limitations, the drug loading capacity of ordinary soluble microneedles is very limited, usually only a few nanograms to a dozen nanograms of drug loading per needle

Method used

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  • Base type microneedle array and preparing method thereof
  • Base type microneedle array and preparing method thereof
  • Base type microneedle array and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prepare the sulforhodamine solution of 1 mg / ml as the labeled model drug (because the sulforhodamine solution will turn red when exposed to water and be visible under fluorescent conditions), instead of the drug; take 100 microliters of the solution and drop it on the PDMS On the microneedle template, under vacuum conditions, after standing for 15 minutes, absorb the excess sulforhodamine solution on the surface, and continue to vacuum for 30 minutes until the red color is completely invisible; take PVA and sucrose with a mass ratio of 5:4:10 The mixed solution prepared with ultrapure water was added to the PDMS microneedle template. After 2 hours, the PDMS template was placed in a fume hood and dried for 24 hours; After the particles are melted, they are molded while they are hot, and demolded after cooling to obtain a base-type microneedle array.

[0020] The pedestal microneedle array prepared above is an array formed by uniformly arranged microneedles perpendicular ...

Embodiment 2

[0022] Prepare the sulforhodamine solution of 1 mg / ml as the labeled model drug (because the sulforhodamine solution will turn red when exposed to water and be visible under fluorescent conditions), instead of the drug; take 100 microliters of the solution and drop it on the PDMS On the microneedle template, under vacuum conditions, after standing still for 15 minutes, absorb the excess sulforhodamine solution on the surface, and continue to vacuum for 30 minutes until the red color is completely invisible; take PVA, shell The mixed solution prepared by polysaccharide and ultrapure water was added to the PDMS microneedle template. After 2 hours, the PDMS template was placed in a fume hood and dried for 24 hours; the polylactic acid particles were placed on the PDMS microneedle template and dried in a vacuum at 198 degrees. In the box, after the particles are melted, they are molded while they are hot, and then demoulded after cooling to obtain a base-type microneedle array.

...

Embodiment 3

[0025] Prepare the sulforhodamine solution of 1 mg / ml as the labeled model drug (because the sulforhodamine solution will turn red when exposed to water and be visible under fluorescent conditions), instead of the drug; take 100 microliters of the solution and drop it on the PDMS On the microneedle template, under vacuum conditions, after standing still for 15 minutes, absorb the excess sulforhodamine solution on the surface, and continue to vacuum for 30 minutes until the red color is completely invisible; take polyethylene with a mass ratio of 5:4:10, The mixed solution prepared by chitosan and ultrapure water was added to the PDMS microneedle template. After 2 hours, the PDMS template was placed in a fume hood and dried for 24 hours; In a vacuum drying oven, after the particles are melted, they are molded while they are hot, and demolded after cooling to obtain a base-type microneedle array.

[0026] The pedestal microneedle array prepared above is an array formed by unifor...

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Abstract

The invention belongs to the technical field of administration equipment and relates to a base type microneedle array and a preparing method thereof. The base type microneedle array is perpendicular to a base and is formed by microneedles distributed evenly, wherein 100-10, 000 microneedles are arranged in each square of centimeter. The microneedles comprise medicine containing pointed ends and microneedle pedestals. The medicine containing pointed ends are made of soluble polymer colloid containing medicine ingredients. The microneedle pedestals are made of biodegradable polymer materials. Compared with the prior art, according to the designed and prepared base type microneedle array, medicine is concentrated at the upper pointed ends, due to the fact that the pointed ends are of the special geometric construction and have enough rigidity, the pointed ends can effectively pierce the stratum corneum of the surface layer of the skin by 100%, enter the hypoderm and be separated from the pedestals and left at the hypoderm to be absorbed, and thus the effects that the medicine quickly enters the hypoderm and is efficiently released are achieved. Not only is the medicine carried at the upper ends of the base type microneedle array, but also medicine carried on the pedestals of the base type microneedle array can be conveyed into the skin, the medicine loading capacity of each microneedle is greatly increased, and the administration efficiency is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of drug delivery equipment, and in particular relates to a base-type microneedle array and a preparation method thereof. Background technique [0002] Generally speaking, different administration methods have different therapeutic effects. At present, most drugs are taken orally in the form of tablets or capsules to achieve curative effect, but this makes many peptide and protein drugs have been decomposed and digested when they pass through the gastrointestinal tract and liver, making them ineffective. Although injection by injection is direct and effective, it will cause great pain to the patient, and it is easy to cause trauma or even infection, and the difficulty of its operation also makes the patient unable to complete the injection process by himself. As a new way of drug delivery, transdermal drug delivery can avoid the above-mentioned defects on the basis of effective treatment. We know that skin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K39/00A61K38/28A61K38/27A61K9/00A61K47/32A61K47/34
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 郭新东朱丹丹李秋玉
Owner BEIJING UNIV OF CHEM TECH