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A method for preparing luteolin/sbe-β-cd inclusion complex

A technology of luteolin and clathrates, which is applied in the direction of pharmaceutical formulations, drug combinations, medical preparations of non-active ingredients, etc., can solve the problems of poor water solubility of luteolin, and achieve good water solubility, good repeatability, and preparation The effect of simple method

Inactive Publication Date: 2018-10-16
CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the poor water solubility of luteolin, it is difficult to make it into a new dosage form of luteolin to improve drug solubility.

Method used

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  • A method for preparing luteolin/sbe-β-cd inclusion complex
  • A method for preparing luteolin/sbe-β-cd inclusion complex
  • A method for preparing luteolin/sbe-β-cd inclusion complex

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Experimental program
Comparison scheme
Effect test

Embodiment

[0016] 1 Instruments and materials

[0017] 1.1 Instrument

[0018] High-performance liquid chromatography, SPD-20A detector and chromatographic data processing system (Shimadzu, Japan); UV2600 ultraviolet-visible spectrophotometer (Shimadzu, Japan); Discovery DV215CD electronic balance (OHAUS Corporation, USA); CS101-1E electric heater Blast drying oven (Chongqing Wanda Instrument Co., Ltd.); G16 medical centrifuge (Beijing Baiyang Medical Instrument Co., Ltd.); KQ3200DB CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); HITECH Edi-S10UV laboratory pure water System (Shanghai Hetai Instrument Co., Ltd.); THZ-82 water bath constant temperature oscillator (Jintan Ronghua Instrument Manufacturing Co., Ltd., Jiangsu Province); Fourier transform infrared spectrometer (Thermo Fisherscientific, USA); TGA / DSC1STAR e System (METTLER1100LF).

[0019] 1.2 Reagent

[0020] Luteolin reference substance (Chengdu Mansite Biotechnology Co., Ltd., batch number MUST-14050411...

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Abstract

The invention discloses a method for preparing a luteolin / SBE-beta-CD (sulfobutyl ether-beta-cyclodextrin) inclusion compound, and belongs to the technical field of Chinese medicinal preparations. The method comprises the following steps of uniformly mixing luteolin and SBE-beta-CD according to a mass ratio of 1:2, slowly adding 100 microliters of ultrapure water, and performing grinding for 70min to obtain an initial inclusion compound; drying the initial inclusion compound for 1h at 60 DEG C, grinding the initial inclusion compound, placing the powder in a Buchner funnel lined with filter paper, washing the powder with absolute ethyl alcohol, extracting residues, and performing drying for 20min at 60 DEG C to obtain the luteolin / SBE-beta-CD inclusion compound. According to the method, the feeding ratio, the grinding time and the amount of water are taken as factors for consideration, and the formula is preferably prepared by an orthogonal test method; the solubility of the prepared luteolin / SBE-beta-CD inclusion compound is greatly improved; the preparation method is simple, more satisfied inclusion rate and yield are achieved, and production and clinical requirements can be met.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a method for preparing a luteolin / SBE-β-CD inclusion compound. Background technique [0002] Luteolin (luteolin) is a natural flavonoid compound, which is widely found in natural medicinal materials such as Prunella vulgaris, honeysuckle, and chrysanthemum, and has anti-oxidative, anti-inflammatory, and antibacterial effects. Studies in recent years have confirmed that luteolin is a topoisomerase inhibitor, which can produce anti-tumor effects through multiple targets, multiple pathways, and multiple links, such as directly interfering with the growth and metabolism of tumor cells, inducing their apoptosis; inhibiting Tumor metastasis; by enhancing the body's immunity, inhibiting the growth of vascular endothelial cells, reducing the angiogenesis of tumor tissue; combining with chemotherapy drugs to produce a sensitizing effect, thereby improving...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K31/352A61P39/06A61P29/00A61P31/04A61P35/00A61P37/04
Inventor 尚京川王兰马赟王靖雯李晶
Owner CHONGQING MEDICAL UNIVERSITY