A kind of controlled-release medicine for treating gastric ulcer induced by excessive gastrin secretion and preparation method thereof

Abstract

The invention relates to the field of pharmacy, in particular to a controlled-release medicine for treating gastric ulcer induced by excessive gastrin secretion and a preparation method thereof. The spatial structure of the controlled-release drug includes from inside to outside: a western medicine pill core, an inner coating controlled-release layer, a traditional Chinese medicine ointment layer and an outer coating layer; the described western medicine pill core is lansoprazole and gelatin; the inner coating The composition of the controlled-release layer of the coating includes sodium alginate, potassium alginate, pregelatinized starch, low-substituted hydroxypropyl cellulose, ethyl cellulose and cellulose acetate; The ointment layer, its raw material comprises the following components: Radix Bupleurum, Radix Paeoniae Alba, Bergamot, Fried Jianqu, Licorice Root, Radix Ginseng, Tangerine Peel, Coptidis Rhizoma, Citrus Fructus Aurantii, Radix Astragali, Yuanhu, cuttlefish bone powder; the raw material of the outer coating layer Includes No. IV Acrylic Resin and Zeatin. The invention can reasonably control gastric acid in a timely and appropriate amount, and brings good news to the treatment of patients with gastric ulcer.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a controlled-release medicine for treating gastric ulcer induced by excessive gastrin secretion and a preparation method thereof. Background technique [0002] The pace of life in modern cities is accelerating, and various entertainments are essential. Overtime and late nights are also common. Under such mental pressure and irregular life rhythm, many people's stomachs are the first to collapse. Gastric ulcer is one of the common stomach diseases, with an incidence rate of about 10% in the population, and this number is also increasing year by year. Gastric ulcers are different from general skin injuries. Because of the special environment in the stomach, it is more difficult to heal gastric ulcers. If you want to recover quickly from ulcers, you must inhibit the excessive secretion of gastric acid. For most existing gastric ulcers For drugs, it is difficult to accurately suppress gastri...

AI Technical Summary

Problems solved by technology

Gastric ulcers are different from general skin injuries. Because of the special environment in the stomach, it is more difficult to heal gastric ulcers. If you want to recover quickly from ulcers, you must inhibit the excessive secretion of gastric acid. For most existing gastric ulcers For drugs, it is difficult to accurately suppress gastric acid. 1-4 hours after administration, due to the effect of the drug, the secretion of gastric acid decreases rapidly, and the pH in the stomach rises sharply, which hinders the normal digestive function of the stomach. After the effect, the secretion of gastric acid resumes, causing the pH in the stomach to drop again, so that the ulcer is difficult to recover repeatedly, and repeated administration brings inconvenience to the patient. If a drug can be developed that can properly and appropriately treat gastric acid Controlled release agent will bring good news to patients with gastric ulcer

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