Medicine used for treating varicocele induced sterility

A varicocele and drug technology, applied in the field of traditional Chinese medicine, can solve the problems of no obvious improvement in semen quality, unsatisfactory improvement in fertility, and out of reach of primary hospitals, so as to promote blood circulation and improve spermatogenesis Improving and promoting the effect of improving semen quality

Inactive Publication Date: 2015-11-18
QINGDAO HUAREN TECH INCUBATOR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since long-term varicocele has caused varying degrees of functional damage to the seminiferous tubules, interstitial cells, and Sertoli cells of the testis, the quality of semen will not be significantly improved in a short period of time, and the improvement of fertility is still not satisfactory.
Although the application of laparoscopy and microscopic techniques can improve postoperative curative effect to a certain extent, due to the limitations of equipment and special surgical techniques, most primary hospitals are still out of reach.

Method used

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  • Medicine used for treating varicocele induced sterility
  • Medicine used for treating varicocele induced sterility
  • Medicine used for treating varicocele induced sterility

Examples

Experimental program
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preparation example Construction

[0052] The present invention also provides a preparation method of the above-mentioned drug granules, which includes:

[0053] The first step is to weigh Epimedium, Lycium barbarum, Cuscuta, Psoraleae, Astragalus, Chinese Yam, Dendrobium, Mulberry, Gorgon, Miracle, Bullwhip, Fenxinmu, Sanjiapi and Morinda officinalis, extracted with water, purified to obtain the first raw material drug powder;

[0054] In the second step, the remaining raw material drug components are extracted by ethanol percolation to obtain the second raw material drug powder;

[0055] The third step is to mix the first raw drug powder and the second raw drug powder, add 0.4-0.6 times the sucrose powder and 0.1-0.3 times the dextrin of the mixed drug powder, make granules, and dry at 40-50 ° C to obtain Granules.

[0056] The first step is further specifically described as, according to the aforementioned proportion, called Epimedium, Lycium barbarum, Cuscuta, Psoraleae, Astragalus, Chinese yam, barley de...

Embodiment 1

[0059] Example 1 Particle 1

[0060]Weigh 50g of epimedium, 40g of medlar, 35g of dodder, 40g of psoraleae, 30g of astragalus, 30g of yam, 30g of dendrobium, 15g of mulberry, 20g of gorgon, 15g of eucalyptus, 40g of bullwhip, 30g of distracting wood, 20g of Sanjiapi and 15g of Morinda officinalis were crushed into coarse powder, mixed together, and extracted with water. For the first time, add 2.5kg of water, soak for 2 hours, and decoct for 3 hours; for the second time, add 1.3kg of water, soak for 1 hour, and decoct. Boil for 1-2 hours, combine the decoction solution, filter, combine the extract solution, recover ethanol under reduced pressure and concentrate until the concentration of the drug solution is 0.4g crude drug / mL, after suction filtration, the relative density of the filtrate is about 1.06 at 20°C; The filtrate is passed through a macroporous adsorption resin column with a volume of 10 L, and first eluted with deionized water or distilled water 10 times the volum...

Embodiment 2

[0061] Example 2 Particle 2

[0062] Weigh 48g of epimedium, 38g of medlar, 33g of dodder, 38g of psoralen, 28g of astragalus, 28g of yam, 28g of dendrobium, 13g of mulberry, 18g of gorgon, 13g of eucalyptus, 38g of bullwhip, 28g of fenxin, Sanjiapi 18g and Morinda officinalis 13g were crushed into coarse powder, mixed together, extracted with water, the first time added 2.2kg of water, soaked for 2 hours, decocted for 3 hours; the second time added water was 1.1kg, soaked for 1 hour, decocted Boil for 1-2 hours, combine the decoction solution, filter, combine the extract solution, recover ethanol under reduced pressure and concentrate until the concentration of the drug solution is 0.4g crude drug / mL, after suction filtration, the relative density of the filtrate is about 1.06 at 20°C; The filtrate is passed through a macroporous adsorption resin column with a volume of 10 L, and first eluted with deionized water or distilled water 10 times the volume of the resin column, and...

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Abstract

The invention provides a medicine used for treating varicocele induced sterility. The medicine comprises the following active pharmaceutical ingredients: epimedium herb, Chinese ligusticum rhizome, barbary wolfberry fruit, Chinese dodder seed, malaytea scurfpea fruit, tamariskoid spikemoss herb, radix astragali, red paeony root, common anemarrhena rhizome, rhizoma dioscoreae, herb of incisory spleenwort, all-grass of inconspicuous bulbophyllum, Chinese taxillus twig, gordon euryale seed, fruit of largeflower gardenia, suberect spatholobus stem, root of entire micromelum, penis and testis of ox, partition in fruit of English walnut, root of trifoliate acanthopanax, herb of henbit deadnettle and morinda root. The medicine has the beneficial effects that being matched with operative treatment, the medicine can achieve the effects of further promoting blood circulation of testes, improving ischemic hypoxia and metabolism and excretion of toxic substances, promoting improvement of the function of spermatogenesis and the quality of semen and reinforcing the sperm viability.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating varicocele infertility. Background technique [0002] Varicocele (VC) refers to the abnormal elongation, expansion and tortuosity of the venous plexus of the spermatic cord. As early as the 16th century, Ambroise discovered varicocele (Varicocele VC). In 1880, British surgeon Barfield first reported that varicocele can lead to infertility, which occupies the primary position in the cause of male infertility. Generally speaking, about 15% of normal males will have varicocele, but 35% of infertile males will have varicocele, which is related to male infertility. disease are closely related. [0003] Western medicine mainly focuses on spermatic vein ligation to improve the temperature rise, hypoxia, pH change, and retention of toxic substances in the testicular spermatogenesis caused by blood stasis. Since the long-term varicocele has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P9/14A61K35/48
Inventor 不公告发明人
Owner QINGDAO HUAREN TECH INCUBATOR
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