Supercharge Your Innovation With Domain-Expert AI Agents!

Preparing method of 2,6-difluoro-4-bromophenol

A technology of difluorobromobenzene and bromophenol, which is applied in the field of preparation of 2,6-difluoro-4-bromophenol, can solve the problems of product distillation, high production cost, and high safety risk, and achieve low cost and easy Effects of purchasing and reducing operating costs

Active Publication Date: 2015-11-25
VALIANT CO LTD
View PDF7 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the shortcomings of the traditional 2,6-difluoro-4-bromophenol synthesis method, such as high safety risk, high production cost, and product distillation, etc., and provide a 2,6-difluoro-4-bromophenol that is safe and low in production cost. The preparation method of 6-difluoro-4-bromophenol

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparing method of 2,6-difluoro-4-bromophenol
  • Preparing method of 2,6-difluoro-4-bromophenol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Under the protection of nitrogen, add 60.6g of diisopropylamine and 127g of methyl tert-butyl ether into a clean and dry three-necked flask, stir mechanically and lower the temperature to -55°C, and add 240ml of normal The n-hexane solution of butyllithium (the molar concentration of n-butyllithium is 2.5 mol / L), was kept at -55~-50°C for 0.5 hours after dropping, and the LDA reagent was obtained after the keeping.

[0025] 2) Under nitrogen protection, add 115.8g (0.6mol) of 3,5-difluorobromobenzene and 150g of methyl tert-butyl ether into a clean and dry three-necked flask, start stirring, and cool down to the inner temperature of -55°C. Add the LDA reagent obtained in 1) dropwise at an internal temperature of -55~-50°C, and keep warm at -55~-50°C for 2 hours after the dropwise addition;

[0026] 3) After the heat preservation is over, control the internal temperature of the system obtained in 2) to be -55~-50°C, add 81.2g (0.78mol) of trimethyl borate dropwise to ...

Embodiment 2

[0031] 1) Under the protection of nitrogen, add 60.6g of diisopropylamine and 120g of methyl tert-butyl ether into a clean and dry three-necked flask, stir mechanically and lower the temperature to -55°C, and add 240ml of secondary The n-hexane solution of butyllithium (the molar concentration of sec-butyllithium is 2.5 mol / L), was kept at -55~-50°C for 0.5 hours after dropping, and the LDA reagent was obtained after the keeping.

[0032] 2) Under nitrogen protection, add 115.8g (0.6mol) of 3,5-difluorobromobenzene and 150g of methyl tert-butyl ether into a clean and dry three-necked flask, start stirring, and cool down to the inner temperature of -55°C. Control the internal temperature at -55~-50°C and add the reaction solution in 1) dropwise, and keep it at -55~-50°C for 2 hours after dropping,

[0033] 3) After the heat preservation is completed, control the internal temperature of the system obtained in 2) to be -55~-50°C, add 146.6g (0.78mol) triisopropyl borate dropwise,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparing method of 2,6-difluoro-4-bromophenol, in the preparing method, 1-bromo-3,5-difluorobenzene is taken as a raw material, and high purity 2,6-difluoro-4-bromophenol can be prepared by metallization reaction and oxidation reaction. According to a synthesis route of the preparing method, a raw material of low price is adopted, the product is low in cost, easy to operate, and suitable for large-scale and continuous production, and has a very high application prospect.

Description

technical field [0001] The invention relates to a preparation method of 2,6-difluoro-4-bromophenol, which belongs to the field of chemical synthesis. Background technique [0002] 2,6-Difluoro-4-bromophenol is an important intermediate for the synthesis of various liquid crystal monomers. On the one hand, it can undergo etherification reactions with halogen-containing benzene rings, and on the other hand, it can also perform etherification reactions with various boric acids. The coupling reaction prepares fluorine-containing liquid crystal monomers with different properties. This type of liquid crystal monomer has the advantages of low viscosity, high resistivity, fast response speed, and can improve the dielectric constant of mixed crystals. It is very suitable for driving thin film field effect transistors. LCD display. 2,6-difluoro-4-bromophenol, as an important intermediate in the synthesis of various fluorine-containing liquid crystal monomers, has a very good applicat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/01C07C39/27C07F5/02
CPCC07C37/01C07F5/025C07C39/27
Inventor 王磊李鹏周立平沈清于晓伟乔松游瑞行
Owner VALIANT CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com