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Vanilla complex phospholipid liposome and preparation method thereof

A technology of compound phospholipids and liposomes, which is applied in the directions of liposome delivery, pharmaceutical formulations, and drug combinations, can solve the problems of poor intestinal permeability, low bioavailability, and weak absorption by the human body, so as to improve bioavailability. high degree of stability, good stability and little effect of hemolysis

Active Publication Date: 2020-05-08
XINJIANG BIOCHEM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a kind of sweet green orchid compound phospholipid liposome and its preparation method, which overcomes the deficiencies of the above-mentioned prior art, and can effectively solve the problem of existing fragrance The total flavonoids of Qinglan is a drug with poor water solubility, poor intestinal permeability and weak absorption by the human body, resulting in low bioavailability, which can no longer meet the existing needs

Method used

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  • Vanilla complex phospholipid liposome and preparation method thereof
  • Vanilla complex phospholipid liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1, the raw materials of the citronella complex phospholipid liposomes include phospholipids, cholesterol and citronella extract; wherein: the mass ratio of cholesterol to phospholipids is 1:4 to 1:10, and the mass ratio of citronella extract to phospholipids The mass ratio is 1:2 to 1:6.

Embodiment 2

[0028] Embodiment 2, this sweet green orchid compound phospholipid liposome is obtained by the following preparation method: ethanol injection method, the first step, add 1 milligram to 5 mg sweet green orchid extract in 1 milliliter of absolute ethanol, add to the free In the water ethanol, add the extract of Cinnamomum orchid and mix uniformly to obtain the ethanol liquid of Cinnamomum persicae; in the second step, the mass ratio of Cholesterol and phospholipids is 1:4 to 1:10, and the mass ratio of Cinnamomum persicae extract to phospholipids is 1 : 2 to 1: 6, add cholesterol and phospholipids to the ethanol solution of Cymbidium, ultrasonically dissolve, inject the ultrasonically dissolved solution into PBS buffer under constant temperature magnetic stirring, the volume ratio of absolute ethanol and PBS buffer The ratio is 1:2 to 1:6, the ethanol is recovered under reduced pressure, and the probe is ultrasonically homogenized after the ethanol is evaporated. The encapsulat...

Embodiment 3

[0029] Example 3, the citronella complex phospholipid liposomes are obtained by the following preparation method: ammonium sulfate gradient method, the first step, the mass ratio of cholesterol and phospholipids is 1:4 to 1:10, and 1 ml of anhydrous Add 0.1 g to 0.5 g of phospholipid meter to ethanol, add phospholipid and cholesterol to absolute ethanol, ultrasonically dissolve, inject the solution after ultrasonic dissolution into ammonium sulfate aqueous solution under constant temperature magnetic stirring, and the absolute ethanol and ammonium sulfate aqueous solution The volume ratio is 1:1 to 1:5, the ethanol is recovered under reduced pressure and the ethanol is evaporated. After the ethanol is evaporated, the probe is ultrasonically homogenized. After the probe is ultrasonically homogenized, it is centrifuged. Obtain blank complex phospholipid liposomes; the second step, according to 1 milliliter of PBS buffer solution, add 1 milligram to 5 milligrams of sweet green orc...

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Abstract

The invention relates to the technical field of dracocephalum moldavuca L compound phospholipid lipidosome, in particular to dracocephalum moldavuca L compound phospholipid lipidosome and a preparation method thereof. The dracocephalum moldavuca L compound phospholipid lipidosome comprises raw materials of phospholipid, cholesterol and dracocephalum moldavuca L extracts, wherein the mass ratio of cholesterol to phospholipid is (1:4)-(1:10), the mass ratio of the dracocephalum moldavuca L extracts to phospholipid is (1:2)-(1:6). Sizes of particles of dracocephalum moldavuca L compound phospholipid lipidosome are uniformly distributed, the stability is good, the hemolytic activity is small, the toxicity is low, the drug loading capacity is high, drug release can be better promoted, and the bioavailability is improved; meanwhile, the dracocephalum moldavuca L compound phospholipid lipidosome can be stored for 4-6 months, storage and transportation are facilitated, and the dracocephalum moldavuca L compound phospholipid lipidosome is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of sweet blue orchid complex phospholipid liposome, and relates to sweet green orchid compound phospholipid liposome and a preparation method thereof. Background technique [0002] DracocephalummoldavucaL, Uyghur named Badland Jibuya, is an annual herb of Lamiaceae Dracocephalummoldavuca L. It is a folk medicine in Xinjiang Uyghur. Diuretic effect, its main component is flavonoids, has a clear cardioprotective effect. [0003] Composite phospholipid liposome is a new technology that has emerged in recent years. It is a spherical drug carrier with a phospholipid bilayer with different phase regions and a biomembrane structure composed of two different phospholipids arranged in phases and cholesterol. The main feature is that two kinds of phospholipids with different phase transition temperatures are used as membrane materials during the preparation process (one is higher than normal temperature, the other is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K36/53A61K47/24A61P9/00
Inventor 邢建国黄伟何承辉于宁姜雯曾诚郑瑞芳刘君琳王云飞古丽斯坦·阿吾提帕依曼·亥米提
Owner XINJIANG BIOCHEM PHARMA CO LTD
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