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High oil content biological composite membrane and preparation method thereof

A bio-composite membrane, oil content technology, applied in the field of medicine, can solve the problems of easy to float on the surface of the membrane, unstable products, inconvenient use, etc., to block the invasion of bacteria and effective particles, reduce infection, and achieve good permeability. sexual effect

Active Publication Date: 2015-12-02
上海美宝生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of sesame oil in the biofilm prepared by this method is extremely low, only 1%-6% of the chitosan derivative solution; Even with such a low content of sesame oil, it is easy to float out of the surface of the film, resulting in product instability, further reduction of oil content, inconvenient use, etc.

Method used

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  • High oil content biological composite membrane and preparation method thereof
  • High oil content biological composite membrane and preparation method thereof
  • High oil content biological composite membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1) Weigh 2 g of carboxymethyl chitosan, add it to 100 ml of purified water, and stir until completely dissolved;

[0037] 2) Squeeze the prepared solution into absolute ethanol to perform displacement dehydration to form a film;

[0038] 3) taking out after fully swelling the carboxymethyl chitosan film that step 2) is made in the sesame oil;

[0039] 4) Spray 2 g of carboxymethyl chitosan powder around the surface of the obtained carboxymethyl chitosan film containing sesame oil, dry at room temperature, seal and sterilize for preservation.

Embodiment 2

[0041] 1) Weigh 5 g of carboxymethyl chitosan, add it to 100 ml of purified water, and stir until completely dissolved;

[0042] 2) drying the prepared solution to form a film at room temperature;

[0043] 3) taking out after fully swelling the carboxymethyl chitosan film that step 2) is made in the sesame oil;

[0044] 4) the surface of the carboxymethyl chitosan film containing sesame oil of the gained is sprayed with the 10ml carboxymethyl chitosan solution prepared as in step 1) method, dried at normal temperature, sealed and sterilized for preservation.

Embodiment 3

[0046] 1) Weigh 5 g of carboxymethyl chitosan, add it to 100 ml of purified water, and stir until completely dissolved;

[0047] 2) The prepared solution is freeze-dried at room temperature to form a film;

[0048] 3) taking out after fully swelling the carboxymethyl chitosan film that step 2) is made in the sesame oil;

[0049] 4) the surface of the carboxymethyl chitosan film containing sesame oil of the gained is sprayed with the 10ml carboxymethyl chitosan solution prepared as in step 1) method, dried at normal temperature, sealed and sterilized for preservation.

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Abstract

The invention relates to a high oil content biological composite membrane and a preparation method thereof. The biological composite membrane contains water-soluble biopolymer materials and oily substances, wherein the content (W / W) of the oily substances is 20-95% of the composition. The high oil content biological composite membrane is an ideal medical dressing and has a double-layer membrane structure. The membrane has certain flexibility and strength, the outer-layer membrane can absorb and then gradually dissolve wound seepage, and thus the inner-layer membrane can release the oily substances capable of promoting wound healing and simultaneously can absorb the wound seepage to form gel; adhesion with a wound surface can be avoided, the dressing change is convenient, secondary damage can not be caused, and physiologic wetting of the wound can be kept; and the high oil content biological composite membrane has antibacterial and anti-inflammatory effects.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a biocomposite film with high oil content and a preparation method thereof. Background technique [0002] Human body surface wounds include burns, abrasions, mechanical injuries, surgical incisions, skin donor sites, and various skin ulcers. How to repair wounds, promote wound healing, and improve the function and appearance of the healed skin is an important topic in the field of surgery. key issues. At present, there is a broad market demand for wound dressings, and the existing dressings cannot meet the requirements of patients. Therefore, it is very necessary to research and develop a new generation of body surface wound dressings with good biocompatibility, biodegradability, and tissue-inducing properties. . [0003] An ideal dressing should have the following functions: (1) keep the wound surface moist and conducive to wound healing; (2) keep the wound at a constant temperature (3...

Claims

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Application Information

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IPC IPC(8): A61L15/34A61L15/28A61L15/32A61L15/24A61L15/44A61L15/18C08J7/04C08J5/18C08L5/08C08L5/04C08L29/04
Inventor 成立萍魏敏商庆新
Owner 上海美宝生命科技有限公司