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A method for producing a fully biodegradable vascular stent and the vascular stent obtained therefrom

A biodegradable, vascular stent technology, used in medical science, surgery, etc., can solve the problems of difficult endothelialization of the inner surface of the stent, and the inability to industrialize large-scale production of vascular stents, so as to avoid potential safety hazards in the later stage, and to achieve good clinical passability. The effect of heat-affected zone reduction

Active Publication Date: 2018-03-30
SHANDONG HUAAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In order to solve the problems in the above-mentioned prior art that the fully biodegradable vascular stent cannot be industrially produced on a large scale and the inner surface of the stent is difficult to re-endothelialize, the present invention aims to provide a method for producing a fully biodegradable vascular stent and Vascular stents thus obtained

Method used

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  • A method for producing a fully biodegradable vascular stent and the vascular stent obtained therefrom
  • A method for producing a fully biodegradable vascular stent and the vascular stent obtained therefrom
  • A method for producing a fully biodegradable vascular stent and the vascular stent obtained therefrom

Examples

Experimental program
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Effect test

Embodiment 1

[0069] Take by weighing 950 grams of degradable polymer material particle L-polylactic acid (LPLA), its intrinsic viscosity range is 3.2-4.3dl / g; weigh 50 grams of degradable polymer material particle DL-polylactic acid (DLPLA), its characteristic The viscosity range is 1.5-2.8dl / g. Vacuum-dry the LPLA and DLPLA polymer particles separately to make the water content 250ppm, and then use a twin-screw pipe extruder to form the pipe support body. Among them, LPLA is melted on one of the screws, and DLPLA is melted on the other screw. The melts of the two screws are separately metered by their respective metering pumps and then uniformly mixed in the static mixture, so that the pipe support body can be obtained through the extrusion of the screws.

[0070] In a water bath at 100°C, the primary stretching of the tubular stent body was carried out by ADDR8 times and LDDR3 times to form a primary stent body with an outer diameter of 4mm and a wall thickness of 1.5mm.

[0071] In a ...

Embodiment 2

[0081] Weigh 900 grams of degradable polymer material particles L-polylactic acid (LPLA), whose intrinsic viscosity ranges from 3.2-4.3dl / g; weigh 100 grams of degradable polymer material particles polylactide-cocaprolactone (PLC) , and its intrinsic viscosity ranges from 2.8-3.4dl / g (trade name: Purac 9032PLC). Vacuum-dry the LPLA and PLC polymer particles separately to make the water content 300ppm, and then use a single-screw pipe extruder to form the pipe support body. Among them, LPLA and PLC are uniformly mixed and melted on the screw, so that the pipe support body can be obtained through the extrusion of the screw.

[0082] In a water bath at 0°C, the primary stretching of the tubular stent body was carried out by 20 times of ADDR and 5 times of LDDR to form a primary stent body with an outer diameter of 1.8mm and a wall thickness of 0.65mm.

[0083] In a water bath at 50°C, by the internal pressure expansion method, the primary stent body is stretched axially -0.5 tim...

Embodiment 3

[0093] Take by weighing 950 grams of degradable polymer material particle L-polylactic acid (LPLA), its intrinsic viscosity range is 3.2-4.3dl / g; weigh 50 grams of degradable polymer material particle DL-polylactic acid (DLPLA), its characteristic The viscosity range is 1.5-2.8dl / g. Vacuum-dry the LPLA and DLPLA polymer particles separately to make the water content 250ppm, and then use a twin-screw pipe extruder to form the pipe support body. Among them, LPLA is melted on one of the screws, and DLPLA is melted on the other screw. The melts of the two screws are separately metered by their respective metering pumps and then uniformly mixed in the static mixture, so that the pipe support body can be obtained through the extrusion of the screws.

[0094] In a water bath at 100°C, the primary stretching of the tubular stent body was carried out by ADDR12 times and LDDR3.5 times to form a primary stent body with an outer diameter of 4mm and a wall thickness of 1.5mm.

[0095] In...

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Abstract

The invention relates to a method for producing a fully biodegradable vascular stent, comprising: S1, vacuum-drying degradable polymer material particles and forming a pipe stent body through a pipe extruder; S2, performing primary stretching on the pipe stent body Forming the nascent stent body; S3, biaxially stretching the nascent stent body to form a microcrystalline lattice structure stent body; S4, cutting the microcrystalline lattice structure stent body by a femtosecond laser cutting machine to form a mesh hollow stent body; S5, pressing and gripping the mesh hollow stent body to form a final vascular stent. The present invention also provides a fully biodegradable vascular stent obtained by the above method. The fully biodegradable vascular stent provided by the present invention can not only temporarily support the vessel wall, but also inhibit early thrombosis and late neointimal hyperplasia, and can also be used as a carrier for local delivery of drugs, effectively preventing acute vascular occlusion after stent placement and reduce the incidence of restenosis.

Description

technical field [0001] The present invention relates to a vascular stent, and more particularly to a method for producing a fully biodegradable vascular stent and the vascular stent obtained therefrom. Background technique [0002] As an effective interventional technique, minimally invasive implantation of vascular stents is widely used in the treatment of vascular stenosis. The tubular hollow metal stent is placed in the diseased part through surgery to effectively support the blood vessels and dredge the stenotic blood vessels. The surgery does not cause major trauma to the patient. Although vascular stenting can effectively reduce the rate of restenosis after percutaneous transluminal coronary angioplasty (PTCA), restenosis still occurs with the proliferation of vascular smooth muscle cells. In-stent restenosis occurs in 20%-30% of cases, and the incidence of in-stent restenosis can be as high as 30%-70% in patients with diabetes, small vessel disease, long lesion, chro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/16A61L31/14
Inventor 黄彬魏征李建军
Owner SHANDONG HUAAN BIOTECH CO LTD