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Method for producing completely biodegradable intravascular stent and produced intravascular stent

A biodegradable and vascular stent technology, which is applied in medical science, surgery, etc., can solve the problems that vascular stents cannot be industrialized and mass-produced, and the inner surface of the stent is difficult to endothelialize, so as to avoid late safety hazards, good clinical passability, and Effect of Heat Affected Zone Reduction

Active Publication Date: 2015-12-16
SHANDONG HUAAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In order to solve the problems in the above-mentioned prior art that the fully biodegradable vascular stent cannot be industrially produced on a large scale and the inner surface of the stent is difficult to re-endothelialize, the present invention aims to provide a method for producing a fully biodegradable vascular stent and Vascular stents thus obtained

Method used

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  • Method for producing completely biodegradable intravascular stent and produced intravascular stent
  • Method for producing completely biodegradable intravascular stent and produced intravascular stent
  • Method for producing completely biodegradable intravascular stent and produced intravascular stent

Examples

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Effect test

Embodiment 1

[0069] Take by weighing 950 grams of degradable polymer material particle L-polylactic acid (LPLA), its intrinsic viscosity range is 3.2-4.3dl / g; weigh 50 grams of degradable polymer material particle DL-polylactic acid (DLPLA), its characteristic The viscosity range is 1.5-2.8dl / g. Vacuum-dry the LPLA and DLPLA polymer particles separately to make the water content 250ppm, and then use a twin-screw pipe extruder to form the pipe support body. Among them, LPLA is melted on one of the screws, and DLPLA is melted on the other screw. The melts of the two screws are separately metered by their respective metering pumps and then uniformly mixed in the static mixture, so that the pipe support body can be obtained through the extrusion of the screws.

[0070] In a water bath at 100°C, the primary stretching of the tubular stent body was carried out by ADDR8 times and LDDR3 times to form a primary stent body with an outer diameter of 4mm and a wall thickness of 1.5mm.

[0071] In a ...

Embodiment 2

[0081] Weigh 900 grams of degradable polymer material particles L-polylactic acid (LPLA), whose intrinsic viscosity ranges from 3.2-4.3dl / g; weigh 100 grams of degradable polymer material particles polylactide-cocaprolactone (PLC) , its intrinsic viscosity range is 2.8-3.4dl / g (trade name: Purac9032PLC). Vacuum-dry the LPLA and PLC polymer particles separately to make the water content 300ppm, and then use a single-screw pipe extruder to form the pipe support body. Among them, LPLA and PLC are uniformly mixed and melted on the screw, so that the pipe support body can be obtained through the extrusion of the screw.

[0082] In a water bath at 0°C, the primary stretching of the tubular stent body was carried out by 20 times of ADDR and 5 times of LDDR to form a primary stent body with an outer diameter of 1.8mm and a wall thickness of 0.65mm.

[0083] In a water bath at 50°C, by the internal pressure expansion method, the primary stent body is stretched axially -0.5 times and r...

Embodiment 3

[0093] Take by weighing 950 grams of degradable polymer material particle L-polylactic acid (LPLA), its intrinsic viscosity range is 3.2-4.3dl / g; weigh 50 grams of degradable polymer material particle DL-polylactic acid (DLPLA), its characteristic The viscosity range is 1.5-2.8dl / g. Vacuum-dry the LPLA and DLPLA polymer particles separately to make the water content 250ppm, and then use a twin-screw pipe extruder to form the pipe support body. Among them, LPLA is melted on one of the screws, and DLPLA is melted on the other screw. The melts of the two screws are separately metered by their respective metering pumps and then uniformly mixed in the static mixture, so that the pipe support body can be obtained through the extrusion of the screws.

[0094] In a water bath at 100°C, the primary stretching of the tubular stent body was carried out by ADDR12 times and LDDR3.5 times to form a primary stent body with an outer diameter of 4mm and a wall thickness of 1.5mm.

[0095] In...

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Abstract

The invention relates to a method for producing a completely biodegradable intravascular stent, wherein the method comprises the following steps: S1. drying degradable polymer material particles in a vacuum environment and forming a pipe stent main body by virtue of a pipe extruder; S2. primarily stretching the pipe stent main body so as to obtain a primary stent main body; S3. stretching the primary stent main body in a biaxial mode so as to obtain a stent main body of a microcrystalline grid structure; S4. cutting the stent main body of the microcrystalline grid structure by virtue of a femtosecond laser cutting machine so as to obtain a net-shaped hollowed-out stent main body; and S5. pressing and holding the net-shaped hollowed-out stent main body, so as to finally form the intravascular stent. The invention also provides a completely biodegradable intravascular stent produced by the method. The completely biodegradable intravascular stent provided by the invention not only can be used for temporarily supporting vascular wall but also can be used for inhibiting early thrombosis and late new intima hyperplasia, and the intravascular stent can also serve as a carrier for the local delivery of drugs, so as to effectively prevent vessel occlusion after the implantation of the stent and to reduce restenosis rate.

Description

technical field [0001] The present invention relates to a vascular stent, and more particularly to a method for producing a fully biodegradable vascular stent and the vascular stent obtained therefrom. Background technique [0002] As an effective interventional technique, minimally invasive implantation of vascular stents is widely used in the treatment of vascular stenosis. The tubular hollow metal stent is placed in the diseased part through surgery to effectively support the blood vessels and dredge the stenotic blood vessels. The surgery does not cause major trauma to the patient. Although vascular stenting can effectively reduce the rate of restenosis after percutaneous transluminal coronary angioplasty (PTCA), restenosis still occurs with the proliferation of vascular smooth muscle cells. In-stent restenosis occurs in 20%-30% of cases, and the incidence of in-stent restenosis can be as high as 30%-70% in patients with diabetes, small vessel disease, long lesion, chro...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/16A61L31/14
Inventor 黄彬魏征李建军
Owner SHANDONG HUAAN BIOTECH CO LTD