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Preparation method for starch-based microgel

A microgel and starch-based technology, applied in the field of starch deep processing, can solve the problems of poor biodegradability, poor biocompatibility, toxicity, etc., and achieve simple steps, wide application, good biocompatibility and biodegradability Effect

Active Publication Date: 2015-12-16
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most microgels are prepared from synthetic macromolecules, such as PMA, PVCL, PDEA, and PAA, etc. However, such macromolecules have the disadvantages of poor biodegradability, poor biocompatibility, and certain toxicity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 20g of waxy cornstarch and disperse it into 100mL ethanol solution with a mass fraction of 50% to obtain a starch lactoalcohol solution. Use a microwave field to treat the starch lactoalcohol solution with a microwave power of 1000W and a treatment time of 10min to obtain an amorphous granular state. starch.

[0020] Disperse 5 g of the prepared amorphous granular starch into 50 mL of isopropanol solution with a mass concentration of 90% to prepare starch milk, add 2 g of sodium hydroxide to the starch milk for alkalization, alkalinize at 35 °C for 1 hour, and then add Add 3 g of sodium chloroacetate to the system for etherification, etherification at 40° C. for 2 hours, and the obtained carboxymethyl starch has a degree of substitution of 0.7.

[0021] Dissolve 1g of carboxymethyl starch and 0.5g of β-cyclodextrin prepared above into 100mL of 1M sodium hydroxide solution, mix well to prepare aqueous phase solution A; dissolve 0.3g of sodium trimetaphosphate into 1...

Embodiment 2

[0025] Take 20g of waxy cornstarch and disperse it into 100mL ethanol solution with a mass fraction of 50% to obtain a starch lactoalcohol solution. Use a microwave field to treat the starch lactoalcohol solution. The microwave power is 1000W and the treatment time is 20min to obtain an amorphous granular state. starch.

[0026] Disperse 5 g of the prepared amorphous granular starch into 50 mL of 90% isopropanol solution to prepare starch milk, add 2.8 g of sodium hydroxide to the starch milk for alkalization, alkalinize at 40 ° C for 2 hours, and then add to the system Add 4g of sodium chloroacetate for etherification, etherification at 40°C for 4 hours, and the obtained carboxymethyl starch has a degree of substitution of 0.98.

[0027] Dissolve 1g of carboxymethyl starch and 0.5g of β-cyclodextrin prepared above into 100mL of 1M sodium hydroxide solution, mix well to prepare aqueous phase solution A; dissolve 0.3g of sodium trimetaphosphate into 10mL of 1M sodium hydroxide ...

Embodiment 3

[0031] Take 25g of waxy cornstarch and disperse it into 100mL ethanol solution with a mass fraction of 50% to obtain a starch lactoalcohol solution. Use a microwave field to treat the starch lactoalcohol solution with a microwave power of 1200W and a treatment time of 20min to obtain an amorphous granular state. starch.

[0032] Disperse 5 g of the prepared amorphous granular starch into 50 mL of isopropanol solution with a mass concentration of 90% to prepare starch milk, add 2.4 g of sodium hydroxide to the starch milk for alkalization, alkalinize at 40 °C for 2 hours, and then Add 3.5 g of sodium chloroacetate to the system for etherification, etherification at 50° C. for 2 hours, and the obtained carboxymethyl starch has a degree of substitution of 0.83.

[0033] Dissolve 1.5g of carboxymethyl starch and 0.7g of β-cyclodextrin prepared above into 100mL of 1M sodium hydroxide solution, mix well to prepare aqueous phase solution A; dissolve 0.5g of sodium trimetaphosphate in...

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Abstract

The invention relates to a preparation method for a starch-based microgel and belongs to the technical field of starch deep processing. By taking pH sensitive carboxymethyl starch and beta-cyclodextrin with an embedding characteristic as raw materials, a carboxymethyl starch / beta-cyclodextrin compound microgel is prepared by virtue of an inverse emulsion polymerization method. The morphological structure of the target starch-based microgel prepared by the method provided by the invention is spherical and the grain size distribution is 10-20 [mu]m. The microgel has pH sensitivity, hydrophobic embedding property and good biocompatibility and biodegradability, and has wide use in the field of foods, medicines and the like.

Description

technical field [0001] The present invention relates to a preparation method of starch-based microgel, in particular to a preparation method of carboxymethyl starch with pH-sensitive carboxymethyl starch and β-cyclodextrin with embedding characteristics and adopting inverse emulsion polymerization to prepare carboxymethyl starch The method for the composite microgel of methyl starch / beta-cyclodextrin belongs to the technical field of starch deep processing. Background technique [0002] Smart microgels refer to microgels that respond to stimuli in response to changes in external conditions (such as temperature, pH, light, ionic strength, electric or magnetic fields, etc.). According to different sources of raw materials, microgels can be divided into synthetic microgels and natural microgels. Most microgels are prepared from synthetic macromolecules, such as PMA, PVCL, PDEA, and PAA, etc. However, such macromolecules have disadvantages such as poor biodegradability, poor bi...

Claims

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Application Information

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IPC IPC(8): C08B31/00C08B37/16
Inventor 田耀旗章宝陈海龙金征宇孙冰华龙杰李晓晓徐学明
Owner JIANGNAN UNIV
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