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Amoxicillin preparation and preparation method thereof

A technology of amoxicillin and preparations, which is applied in the field of veterinary drug technology applications, can solve problems such as the influence of drug stability without consideration, and achieve the effects of ensuring drug efficacy, improving therapeutic effect, and high solubility

Active Publication Date: 2015-12-23
QINGDAO KDN BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent only solves the problem of water solubility of amoxicillin soluble powder, and does not consider the influence of water hardness, water temperature and metal ions on drug stability during use

Method used

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  • Amoxicillin preparation and preparation method thereof
  • Amoxicillin preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment provides a kind of amoxicillin preparation, comprises amoxicillin 5kg, sodium carbonate 3kg, sodium lauryl sulfate 1kg, poloxamer 1880.5kg, disodium oxalate tetraacetate 0.2kg, polyethylene glycol 400015kg, lactose 75.3kg.

[0032] This embodiment also provides the preparation method of the above-mentioned amoxicillin preparation, including the following steps: crushing sodium carbonate, sodium lauryl sulfate, poloxamer 188, and disodium oxalate tetraacetate through an 80-mesh sieve and sieving Finally, put it into the mixing tank according to the formula, and mix evenly with the amoxicillin of the formula amount (mixing for 15 minutes); after polyethylene glycol 4000 and lactose are crushed and sieved through an 80 mesh screen, put them into the mixing tank according to the formula , mix evenly (mixed for 25 minutes), subpackage, and get it.

Embodiment 2

[0034] This embodiment provides a kind of amoxicillin preparation, comprises amoxicillin 30kg, sodium carbonate 7kg, sodium lauryl sulfate 2kg, poloxamer 1881kg, disodium oxalate tetraacetate 0.2kg, polyethylene glycol 400015kg , lactose 44.8kg.

[0035] The preparation method of the amoxicillin preparation described in this example is the same as that in Example 1.

Embodiment 3

[0037] This embodiment provides a kind of amoxicillin preparation, comprises amoxicillin 5kg, sodium carbonate 3kg, citric acid 5kg, sodium citrate 2kg, sodium lauryl sulfate 1kg, poloxamer 1880.5kg, oxalic acid tetraacetic acid Disodium 0.2kg, polyethylene glycol 400015kg, lactose 68.3kg.

[0038] This embodiment also provides the preparation method of the above-mentioned amoxicillin preparation, comprising the following steps: sodium carbonate, citric acid, sodium citrate, sodium lauryl sulfate, poloxamer 188, disodium oxalate tetraacetate After crushing and sieving through an 80-mesh sieve, put it into a mixing tank according to the formula, and mix it evenly with the amount of amoxicillin in the formula (mixing for 20 minutes); after crushing and sieving polyethylene glycol 4000 and lactose through an 80-mesh sieve, press The formula is put into the mixing tank, mixed evenly (mixed for 40 minutes), and packaged to obtain final product.

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Abstract

The invention relates to an amoxicillin preparation and a preparation method thereof. The amoxicillin preparation comprises 5-50 parts of amoxicillin, 3-38 parts of a stabilizer, 0.2-10 parts of a solubilizer, 0.1-1 part of a complexing agent and 1-91.7 parts of an auxiliary material. The preparation method comprises the following steps: the stabilizer and the solubilizer are ground and sieved by a sieve with 80-120 meshes and fed into a mixing tank according to a formula to be uniformly mixed with amoxicillin; the auxiliary material is ground and sieved by a sieve with 80-100 meshes and fed into the mixing tank according to a formula to be uniformly mixed, and a finished product is obtained through sub-packaging. The amoxicillin preparation has high water solubility and high stability, and according to 6-mouth acceleration test, the content of amoxicillin is in a prescribed range all along; the use requirement of a doser of a large-scale farm is met; an aqueous solution of the amoxicillin preparation is not prone to be influenced by objective factors such as the temperature, metal ions, ph and the like, the content of effective components can keeps unchanged for 24 hours, and the effect of treatment of livestock colibacillosis caused by Gram-negative bacteria is improved substantially.

Description

technical field [0001] The invention relates to an amoxicillin preparation and a preparation method thereof, in particular to a stable amoxicillin soluble powder preparation suitable for large-scale farms and a preparation method thereof, belonging to the technical application field of veterinary medicine. Background technique [0002] Amoxicillin, also known as amoxicillin or amoxicillin, is one of the most commonly used semi-synthetic penicillin-type broad-spectrum β-lactam antibiotics. It is a white crystalline powder with a half-life of about 61.3 minutes. It is characterized by broad antibacterial spectrum, strong bactericidal power and extremely low toxicity, and is suitable for mild to moderate infections. Amoxicillin is stable under acidic conditions, and the gastrointestinal absorption rate reaches 90%. Amoxicillin has a strong bactericidal effect and a strong ability to penetrate cell membranes. It is one of the most widely used oral semi-synthetic penicillins. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/43A61P31/04A61P11/00A61P29/00
Inventor 徐峰孔祥强毛倩倩刘西锋邵耀东杨鑫
Owner QINGDAO KDN BIOTECH
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