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Method of measuring residual amount of 4-aminoazobenzene in paper for cigarettes

A technology of aminoazobenzene and a determination method, which is applied in the field of determination of 4-aminoazobenzene residues in cigarette paper, can solve the problems of poor qualitative ability, poor chromatographic peak shape, poor thermal stability and the like, and achieves rapid Simple Sensitivity, Avoidance of Matrix Effects, Reduced Interference Effects

Active Publication Date: 2015-12-23
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

GC and HPLC methods have low requirements on instruments and equipment, but are easily affected by impurity interference and poor qualitative ability, so false positive results are prone to occur
Moreover, aromatic amines are highly polar and have poor thermal stability. When analyzed by GC-MS method, the sensitivity is not high and the chromatographic peak shape is poor.

Method used

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  • Method of measuring residual amount of 4-aminoazobenzene in paper for cigarettes
  • Method of measuring residual amount of 4-aminoazobenzene in paper for cigarettes
  • Method of measuring residual amount of 4-aminoazobenzene in paper for cigarettes

Examples

Experimental program
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Effect test

example 1

[0033] 1. Instruments and reagents:

[0034] Tert-butyl methyl ether and methanol are chromatographic grade reagents, sodium hydroxide and sodium sulfate are analytical reagents; distilled water meets the requirements of first-grade water in GB / T6682.

[0035] API4000 quadrupole tandem mass spectrometer; water bath constant temperature oscillator; Swiss Mettler AE163 electronic balance (sensitivity: 0.0001g).

[0036] 2. Sample handling:

[0037] Cut the sample first: the cutting method of tipping paper for cigarettes is carried out in accordance with the regulations of YC171-2008, that is, to accurately cut a sample of tipping paper with a length of 200mm and a width of 40mm (should include a single side); The cutting method is carried out in accordance with the provisions of YC264-2008, that is, the cutting area is about 170cm 2 (That is equivalent to the area of ​​the lining paper used in ordinary cigarette soft box packaging); the cutting method of cigarette rods and b...

example 2

[0044] According to the determination method described in Example 1, another cigarette tipping paper sample was selected, and 4-aminoazobenzene was not detected in the sample.

example 3

[0046] According to the determination method described in Example 1, another inner liner paper sample for cigarettes was selected, and 4-aminoazobenzene was not detected in the sample.

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Abstract

The invention belongs to the technical field of physical and chemical inspection of harmful substance residues in inner liners, tipping paper and carton packaging paper for cigarettes, and particularly relates to a method of measuring the residual amount of 4-aminoazobenzene in paper for the cigarettes. The method specifically comprises the following steps: reducing an azo substance into aromatic amine by sodium dithionite in an alkaline solution; then extracting the aromatic amine in the solution by using tert-butyl methyl ether; carrying out solid-phase dispersion extraction, and then measuring by using a liquid chromatography-tandem mass spectrometry; carrying out internal standard method determination. According to the method disclosed by the invention, the defects of a sample processing method in the prior art are overcome; a sample pretreatment method and instrument detection conditions are optimized, aiming at the tipping paper and the inner liners for the cigarettes, cigarette strips and carbon packaging paper samples. Since a solid-phase extraction column is not needed to pass, instead the simpler and more convenient solid-phase dispersion extraction is used, and the tedious purification and concentration steps, such as rotary evaporation is not needed, the method disclosed by the invention has the advantages of accuracy in operation, high recovery rate, high sensitivity and the like and is rapid, simple and convenient.

Description

technical field [0001] The invention belongs to the technical field of physical and chemical inspection of harmful substance residues in inner liner paper, tipping paper and carton wrapping paper for cigarettes, and mainly relates to the determination technology of azo dyes in inner liner paper, tipping paper and carton wrapping paper for cigarettes Specifically, azo substances are reduced to 4-aminoazobenzene by sodium dithionite in an alkaline solution, and then extracted and purified by liquid-liquid extraction and dispersive solid-phase extraction, and then purified by liquid chromatography tandem mass spectrometry For determination, internal standard method for quantification. Background technique [0002] In the production process of paper including lining paper, tipping paper, carton wrapping paper, etc., various chemicals such as bleaching agents, processing aids, printing inks, antiseptics and bactericides need to be added to improve its quality. Packaging performa...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 杨飞唐纲岭边照阳李中皓范子彦刘珊珊王颖孙莹莹刘岩顺
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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