Preparation method of colloidal brain parenchyma and physical model of cranial brain
A physical model and brain parenchyma technology, applied in the field of medical models, can solve the problems of poor repeatability of experiments, difficulty in analyzing the process and characteristics of temperature changes, complicated and dangerous operations, etc., and achieve the effect of stable performance and repeatable performance.
Active Publication Date: 2018-04-24
ZHEJIANG UNIV
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Problems solved by technology
Due to the complex structure of the brain, it is very difficult to analyze the process and characteristics of temperature changes from a theoretical point of view, and direct research on the brain in vivo requires a craniotomy experiment, which is complicated and dangerous to operate, and the repeatability of the experiment is poor due to individual differences in the human body.
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Embodiment
[0028] Embodiment: the preparation process of a kind of colloidal brain parenchyma of the present embodiment, comprises the following steps:
[0029] 1) Preparation of 1 liter of TBS buffer solution: The function of TBS buffer solution is to keep the pH in the colloid stable for a long time and avoid the growth of bacteria. Mix 24.2 grams of Tris base and 80 grams of NaCl, add deionized water to make a solution to 1L, use a certain concentration of hydrochloric acid solution to adjust the pH value of the mixed solution to about 7.6, and then seal the solution and put it in a sterilizer at 120°C Sterilize at high temperature for 10-20 minutes, take it out after cooling and use it. When not in use, it must be stored at low temperature.
[0030] 2) Configuration of 2% agar powder solution: use a measuring cup to measure 100ml of TBS buffer solution and 900ml of deionized water (volume ratio is 1:9) and mix, weigh 20.0g of agar powder with an electronic scale and add it to the mi...
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Abstract
The invention discloses a method for preparing colloidal brain parenchyma and a physical model of the cranial brain. The physical model of the cranial brain includes a scalp part, a skull part, a colloidal brain parenchyma, a power control module, a data acquisition module and a simulated blood circulation module. The scalp part is attached to the On the surface of the skull part, the colloidal brain parenchyma is poured inside the skull part. The colloidal brain parenchyma is equipped with heating nickel wires, several temperature sensors and several capillary copper tubes. The heating nickel wires are electrically connected to the power control module, and the temperature sensors are connected to the data acquisition module. For electrical connection, the capillary copper tube meets two thick copper tubes, and the thick copper tube passes through the foramen magnum to connect to the simulated blood circulation system. The simulated blood circulation system circulates liquid at the same temperature as the blood into the capillary copper tube. The heating nickel wire generates heat under the power control module; the temperature sensor detects the temperature of various parts of the brain and sends it to the data acquisition module. This protocol is suitable for studies and experiments of temperature changes in the cranial brain.
Description
technical field [0001] The invention relates to the field of medical models, in particular to a method for preparing colloidal brain parenchyma and a physical model of the brain based on real shape and thermodynamic characteristics. Background technique [0002] Temperature has a major impact on the treatment of brain injuries. Studies have shown that temperature has an important impact on many factors such as blood perfusion rate and intracranial pressure after brain injury, and reducing the temperature of the brain can effectively improve the therapeutic effect. From the perspective of neurobiology, the hypothermia treatment of the brain is to reduce the activity of cells by physical means, thereby reducing the oxygen demand and metabolic rate of the brain, and protecting brain cells. Other studies have shown that low temperature can also inhibit the harmful biochemical reactions to the brain after brain injury, inhibit the inflammation caused by the injury, and thus achi...
Claims
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IPC IPC(8): G01N25/20
Inventor 张武明王颖哲熊先胤邓鸿超
Owner ZHEJIANG UNIV