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Nano antibacterial bone filling materials and production method thereof

A filling material and nanotechnology, applied in the field of medical materials, can solve the problems of poor antibacterial effect, easy infection of the affected area, low porosity, etc., and achieve the effect of preventing inflammation of the affected area, reducing pain of patients, and increasing porosity

Inactive Publication Date: 2016-01-06
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the pore size of the bone filling material is small, the porosity is low, and the antibacterial effect is poor. After use, the affected part is easily infected, which brings more serious harm to the patient.

Method used

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  • Nano antibacterial bone filling materials and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A nano antibacterial bone filling material, comprising the following raw materials in parts by weight: 30 parts of hydroxyapatite, 5 parts of nano-silver powder, 2 parts of nano-titanium dioxide, 8 parts of glycerin, 10 parts of polyethyl acetate, 20 parts of citronella extract Parts, 2 parts of nano silicon dioxide, 12 parts of epoxy resin.

[0017] The preparation method of the above-mentioned nano antibacterial bone filling material comprises the following steps:

[0018] Step 1, mix hydroxyapatite, nano-silver powder, nano-titanium dioxide, nano-silicon dioxide and epoxy resin, grind to 800 mesh, put it into the reaction kettle, raise the temperature to 2000°C at a constant speed, keep it warm for 5 minutes, and continue to heat up to 2800°C °C to obtain the first mixed solution, wherein the rate of constant temperature rise is 5 °C / min, and the heating time is 0.5 hours;

[0019] Step 2, when the first mixed liquid is cooled to 40°C, add glycerin and citronella ex...

Embodiment 2

[0021] A nano antibacterial bone filling material, comprising the following raw materials in parts by weight: 35 parts of hydroxyapatite, 8 parts of nano-silver powder, 6 parts of nano-titanium dioxide, 12 parts of glycerin, 15 parts of polyethyl acetate, 26 parts of citronella extract Parts, 6 parts of nano-silica, 15 parts of epoxy resin

[0022] The preparation method of the above-mentioned nano antibacterial bone filling material comprises the following steps:

[0023] Step 1, mix hydroxyapatite, nano-silver powder, nano-titanium dioxide, nano-silica and epoxy resin, grind to 800 mesh, put it into the reaction kettle, raise the temperature to 2200°C at a constant speed, keep it warm for 8 minutes, and continue to heat up to 2800°C °C to obtain the first mixed solution, wherein the rate of constant temperature rise is 8 °C / min, and the heating time is 0.8 hours;

[0024] Step 2, when the first mixed liquid is cooled to 45°C, add glycerin and citronella extract, and stir at...

Embodiment 3

[0026] A nano antibacterial bone filling material, comprising the following raw materials in parts by weight: 38 parts of hydroxyapatite, 10 parts of nano-silver powder, 8 parts of nano-titanium dioxide, 15 parts of glycerin, 18 parts of polyethyl acetate, 28 parts of citronella extract Parts, 8 parts of nano silicon dioxide, 18 parts of epoxy resin.

[0027] The preparation method of the above-mentioned nano antibacterial bone filling material comprises the following steps:

[0028] Step 1, mix hydroxyapatite, nano-silver powder, nano-titanium dioxide, nano-silica and epoxy resin, grind to 800 mesh, put it into the reaction kettle, raise the temperature to 2500°C at a constant speed, keep it warm for 10 minutes, and continue to heat up to 2800°C °C to obtain the first mixed solution, wherein the rate of constant temperature rise is 10 °C / min, and the heating time is 1 hour;

[0029] Step 2, when the first mixed liquid is cooled to 50°C, add glycerin and citronella extract, a...

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PUM

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Abstract

The invention discloses nano antibacterial bone filling materials and a production method thereof. The bone filling materials comprise hydroxyapatite, nano silver powder, nano titanium dioxide, glycerol, polyvinyl acetate, lemongrass extract, nano silicon dioxide and epoxy resin. The production method includes: mixing the hydroxyapatite, the nano silver powder, the nano titanium dioxide, the nano silicon dioxide and the epoxy resin, then grinding into 800-mesh powder, adding into a reaction kettle, heating at a constant speed to 2000-2500 DEG C, keeping the temperature for 5-10 minutes, and heating to 2800 DEG C to obtain first mixed liquid; adding the glycerol and the lemongrass extract when the first mixed liquid is cooled to 40-50 DEG C, and evenly stirring to obtain the nano antibacterial bone filling materials. The nano antibacterial bone filling materials are high in porosity, good in antibacterial effect, and capable of accelerating bone healing and reducing the pain of patients.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a nanometer antibacterial bone filling material and a preparation method thereof. Background technique [0002] Bone filling material is a material used to fill the bone defect cavity or the gap between the bone implant device and the bone bed. Its role is to accelerate the healing of bone defects or to fix bone implants. CN200510084975.8 discloses a bioabsorbable granular porous bone filling material with a particle size of 100-3000 μm, which is used to fill the defect after injury resection or autologous bone transplantation and to reinforce or fill the gum when implanting teeth. The bone filling material is obtained by mixing a particulate substance with a diameter of 100-2000 μm, which is insoluble in an organic solvent and soluble in a liquid in which a bioabsorbable polymer is not dissolved, with a solution in which a bioabsorbable polymer is dissolved in an ...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/54A61L27/56
Inventor 金仲恩全春兰张帆
Owner SUZHOU COSMETIC MATERIALS
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