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Synthesis method of 2-picoline

A synthetic method, picoline technology, applied in chemical instruments and methods, metal/metal oxide/metal hydroxide catalysts, heterogeneous catalyst chemical elements, etc., can solve the problem of high energy consumption, environmental pollution, and reaction components Eliminate the problems of negative impurities and high equipment requirements, and achieve the effects of high-efficiency synthetic methods, improved catalytic activity, and shortened reaction cycles

Inactive Publication Date: 2016-01-06
ANHUI COSTAR BIOCHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these synthetic methods all have disadvantages: the reaction components are impurity, and high-quality products need to go through an impurity treatment process, the energy consumption and the pollution to the environment are high, and the yield is relatively low, which is harmful to the equipment. relatively high requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for synthesizing 2-picoline, the pyridine and methanol are evenly mixed into a feeder at a molar ratio of 1:1.2, and Fe-MnOx-Yb molecular sieves are passed through a 180-mesh sieve to remove impurities and put into a regenerator; The temperature of the vaporization furnace is set to 130 °C, the temperature of the regenerator is set to 550 °C, and the temperature of the fluidized bed is set to 475 °C, the power switch is turned on, and the temperature of the vaporization furnace, the fluidized bed and the regenerator is set to the set value. ; Adjust the circulating amount of the catalyst to control it at 15.5kg / h, adjust the flow rate of the feed pump to 3.5kg / h, after the raw material is gasified in the gasification furnace, it enters the fluidized bed for contact reaction with the catalyst, and observes each temperature control point After 30 minutes of steady-point reaction, sampling and testing; after the desorption of the target product, the solid catalyst ...

Embodiment 2

[0025] A method for synthesizing 2-methylpyridine, the pyridine and methanol are uniformly mixed into a feeder at a molar ratio of 1:1.1, and Fe-MnOx-Yb molecular sieves are passed through a 180-mesh sieve to remove impurities and put into a regenerator; The temperature of the vaporization furnace is set to 140 °C, the temperature of the regenerator is set to 590 °C, and the temperature of the fluidized bed is set to 460 °C, turn on the power switch, and the temperature of the vaporization furnace, the fluidized bed and the regenerator is set to the set value. ; Adjust the circulation amount of the catalyst to control it at 14.5kg / h, adjust the feed pump flow rate to 3.7kg / h, after the raw material is gasified in the gasifier, enter the fluidized bed catalyst for contact reaction, observe the temperature control points of each temperature control point. After the temperature changes, after 30 minutes of stable point reaction, sampling and testing; after desorption of the target...

Embodiment 3

[0028] A method for synthesizing 2-picoline, the pyridine and methanol are uniformly mixed into a feeder at a molar ratio of 1:1.3, and Fe-MnOx-Yb molecular sieves are passed through a 180-mesh sieve to remove impurities and put into a regenerator; The temperature of the vaporization furnace is set to 133 °C, the temperature of the regenerator is set to 550 °C, and the temperature of the fluidized bed is set to 470 °C, and the power switch is turned on, and the temperature of the vaporization furnace, the fluidized bed and the regenerator is set to the set value. ; Adjust the circulation amount of the catalyst to control it at 15kg / h, adjust the flow rate of the feed pump to 4.0kg / h, after the raw material is gasified in the gasification furnace, it enters the fluidized bed for contact reaction with the catalyst, and observes the temperature at each temperature control point. After the temperature changes, after 30 minutes of stable point reaction, sampling and testing; after d...

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Abstract

The invention discloses a synthesis method of 2-picoline. According to the synthesis method, pyridine and methyl alcohol serve as raw materials, and Fe-MnOx-Yb serves as a catalyst. The synthesis method has the advantages that 2-picoline is prepared through one-step synthesis with pyridine and methyl alcohol as the raw materials, a pyridine industry chain is fully completed, the market dependency of pyridine bases of enterprises is reduced, controllable self-adjustability is achieved, and the survival ability of the enterprises is improved; the catalytic activity of the catalyst doped with Yb metal elements is improved by 3-5 times under influences of the characteristics (structure and electron cloud) of the Yb metal elements, the reaction period is shortened, and efficiency is improved; the synthesis method is efficient, the reaction ingredients are simple and easy to treat, energy is saved, and cost is lowered. The synthesis method is an environment-friendly and efficient synthesis technology, the product yield reaches up to 88%, and the pyridine conversion rate reaches 95%.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, in particular to a method for synthesizing 2-picoline. Background technique [0002] 2-Methylpyridine is an important chemical raw material, which is used in the production of 2-vinylpyridine, pesticides, medicines and other fields, and the market demand is large. At present, there are four main ways to synthesize 2-methylpyridine: 1) a small amount of by-products of 2-methylpyridine produced in the process of synthesizing pyridine from carbonyl compounds and ammonia; 2) mass production of 2-methylpyridine in industry The method of pyridine is acrylonitrile and acetone reaction process; 3) acetylene ammonia synthesis 2-methylpyridine process; 4) Chinese invention patent (application number 201210456105.9) discloses 5-ketoacetonitrile as raw material, in the presence of hydrogen A technique for the one-step synthesis of 2-picoline. However, these synthetic methods all have shortcomings...

Claims

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Application Information

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IPC IPC(8): C07D213/16C07D213/127B01J23/889
CPCC07D213/16B01J23/002B01J23/8892B01J2523/00C07D213/127
Inventor 韦永飞李习红王红伟王长才史新龙周林军
Owner ANHUI COSTAR BIOCHEM CO LTD
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