Method for preparing hydroxyapatite and chitosan with shrimp and crab shells as raw materials

A technology of hydroxyapatite and shrimp and crab shells, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as the inability to utilize shrimp and crab shells, achieve simplified pretreatment processes, reduce production costs, and improve utilization rates high effect

Active Publication Date: 2016-01-06
浙江海富海洋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the shortcomings of the prior art described above, the purpose of the present invention is to provide a method for preparing h

Method used

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  • Method for preparing hydroxyapatite and chitosan with shrimp and crab shells as raw materials
  • Method for preparing hydroxyapatite and chitosan with shrimp and crab shells as raw materials
  • Method for preparing hydroxyapatite and chitosan with shrimp and crab shells as raw materials

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example 1

[0028] (1) Shrimp shell pretreatment: the shrimp shell is directly dried and crushed into powder for later use.

[0029] (2) Microwave reaction: Weigh 40g shrimp shell raw material powder into the microwave reactor, add 4.67g diammonium hydrogen phosphate, 4.07g ammonium dihydrogen phosphate and 2.5L deionized water, stir evenly, and add 10wt% of hydrogen Adjust the pH value of sodium aqueous solution to 10.0, control the reaction temperature at 90℃ by adjusting the microwave reaction power 400w, the reaction time is 4h, the product after the microwave reaction is washed with deionized water and dried to obtain nano-hydroxyapatite-chitosan powder Body 16.8520g.

[0030] (3) Product separation: Add 16.8520g of nano-hydroxyapatite-chitosan powder obtained in step (2) to deionized water, and slowly add 10wt% dilute hydrochloric acid while stirring at room temperature to adjust the pH to 4.0. After stirring for 2 hours at room temperature, the solid-liquid separation...

Example Embodiment

[0033] Example 2

[0034] (1) Shrimp shell pretreatment: the shrimp shell is directly dried and crushed into powder for later use.

[0035] (2) Microwave reaction: Weigh 40g shrimp shell raw material powder into a microwave reactor, add 4.67g diammonium hydrogen phosphate, 4.07g ammonium dihydrogen phosphate and 2.5L deionized water, stir evenly, and add 15wt% hydrogen Adjust the pH value of sodium solution at 12.0, control the reaction temperature at 100℃ by adjusting the microwave reaction power 500w, the reaction time is 2h, the product after microwave reaction is washed with deionized water and dried to obtain nano-hydroxyapatite-chitosan The powder is 15.9876g.

[0036] (3) Product separation: Add 15.9876g of nano-hydroxyapatite-chitosan powder obtained in step (2) to deionized water, and slowly add 15wt% dilute hydrochloric acid while stirring at room temperature to adjust the pH to 6.5. After stirring for 24 hours at room temperature, the solid-liquid separation was carried ...

Example Embodiment

[0038] Example 3

[0039] (1) Crab shell pretreatment: The crab shell is directly dried and crushed into powder for later use.

[0040] (2) Microwave reaction: Weigh 40g crab shell raw material powder into the microwave reactor, add 6.34g diammonium hydrogen phosphate, 5.52g ammonium dihydrogen phosphate and 2.5L deionized water, stir evenly, and add 5wt% of hydrogen Adjust the pH value of sodium solution at 8.0, control the reaction temperature at 90℃ by adjusting the microwave reaction power 400w, the reaction time is 8h, the product after microwave reaction is washed with deionized water and dried to obtain nano-hydroxyapatite-chitosan The powder is 18.9652g.

[0041] (3) Product separation: Add 18.9652g of nano-hydroxyapatite-chitosan powder obtained in step (2) to deionized water, and slowly add 5wt% dilute hydrochloric acid while stirring at room temperature to adjust the pH to 4.0. After stirring for 6 hours at room temperature, solid-liquid separation, the solid obtained is...

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Abstract

The invention provides a method for preparing hydroxyapatite and chitosan with shrimp and crab shells as raw materials. The method solves the problem of incapability of full utilization of the shrimp and crab shells in the prior art. According to the invention, in order to simplify pretreatment process of the shrimp and crab shells and that effective substances--calcium carbonate and chitin in the shrimp and crab shells can be fully utilized at the same time, it is only needed to simply pretreat the raw materials; a one-step alkalization microwave method is employed for reaction; added alkali in microwave reaction can dissolve residual protein and fat in the shrimp and crab shells, while complicated pretreatments like protein removal by stewing with alkali and calcium removal by soaking with acid are not needed; thus, reaction time is effectively shortened (from 10 days to 2 to 12 h), and reaction energy barriers can be effectively reduced. Meanwhile, liquid obtained after the microwave reaction is recovered, and the residual protein and fat in the shrimp and crab shells can be fully utilized, so production cost can be reduced, and high efficiency and environmental protection are obtained.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a method for preparing hydroxyapatite and chitosan by using shrimp and crab shells as raw materials. Background technique [0002] Hydroxyapatite is a weakly alkaline (pH=7~9) calcium phosphate salt which is slightly soluble in water. Hydroxyapatite powder has a wide range of uses. Hydroxyapatite ceramics can be prepared by heating to 800-1200°C, or multi-phase ceramics mainly composed of hydroxyapatite, which can be used for hard tissue repair of the human body; Composite with polymer materials, such as polylactic acid, collagen, polyamide, etc., to improve the biocompatibility of the material; it can also be used as a raw material for spraying hydroxyapatite coating on the surface of metal implants such as artificial joints and dental implants . As an important bioactive material, hydroxyapatite has attracted more and more attention. [0003] Chitosan i...

Claims

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Application Information

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IPC IPC(8): C08B37/08C01B25/32
Inventor 赵斌元赵宏刘茫茫周洁
Owner 浙江海富海洋生物科技有限公司
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