Method for preparing hydroxyapatite and chitosan with shrimp and crab shells as raw materials

A technology of hydroxyapatite and shrimp and crab shells, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as the inability to utilize shrimp and crab shells, achieve simplified pretreatment processes, reduce production costs, and improve utilization rates high effect

CN105218698AActive Publication Date: 2016-01-06浙江海富海洋生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2016-01-06

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Abstract

The invention provides a method for preparing hydroxyapatite and chitosan with shrimp and crab shells as raw materials. The method solves the problem of incapability of full utilization of the shrimp and crab shells in the prior art. According to the invention, in order to simplify pretreatment process of the shrimp and crab shells and that effective substances--calcium carbonate and chitin in the shrimp and crab shells can be fully utilized at the same time, it is only needed to simply pretreat the raw materials; a one-step alkalization microwave method is employed for reaction; added alkali in microwave reaction can dissolve residual protein and fat in the shrimp and crab shells, while complicated pretreatments like protein removal by stewing with alkali and calcium removal by soaking with acid are not needed; thus, reaction time is effectively shortened (from 10 days to 2 to 12 h), and reaction energy barriers can be effectively reduced. Meanwhile, liquid obtained after the microwave reaction is recovered, and the residual protein and fat in the shrimp and crab shells can be fully utilized, so production cost can be reduced, and high efficiency and environmental protection are obtained.
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Description

technical field

[0001] The invention belongs to the technical field of chemical industry, and in particular relates to a method for preparing hydroxyapatite and chitosan by using shrimp and crab shells as raw materials. Background technique

[0002] Hydroxyapatite is a weakly alkaline (pH=7~9) calcium phosphate salt which is slightly soluble in water. Hydroxyapatite powder has a wide range of uses. Hydroxyapatite ceramics can be prepared by heating to 800-1200°C, or multi-phase ceramics mainly composed of hydroxyapatite, which can be used for hard tissue repair of the human body; Composite with polymer materials, such as polylactic acid, collagen, polyamide, etc., to improve the biocompatibility of the material; it can also be used as a raw material for spraying hydroxyapatite coating on the surface of metal implants such as artificial joints and dental implants . As an important bioactive material, hydroxyapatite has attracted more and more attention.

[0003] Chitosan i...

Examples

Embodiment 1

[0028] (1) Shrimp shell pretreatment: directly dry the shrimp shell and pulverize it into powder for later use.

[0029] (2) Microwave reaction: Weigh 40g shrimp shell raw material powder and put it into a microwave reactor, add 4.67g diammonium hydrogen phosphate and 4.07g ammonium dihydrogen phosphate and 2.5L deionized water, stir well, and oxidize with 10wt% hydroxide Adjust the pH value of the sodium solution at 10.0, control the reaction temperature at 90°C by adjusting the microwave reaction power of 400w, and the reaction time is 4h. The product after the microwave reaction is washed with deionized water and dried to obtain nano-hydroxyapatite-chitosan powder Body 16.8520g.

[0030] (3) product separation: the 16.8520g nano-hydroxyapatite-chitosan powder body that step (2) obtains is added deionized water, slowly adds the dilute hydrochloric acid of 10wt% while stirring at room temperature and adjusts the pH value to 4.0, in After stirring for 2 hours at room temperat...

Embodiment 2

[0034] (1) Shrimp shell pretreatment: directly dry the shrimp shell and pulverize it into powder for later use.

[0035] (2) Microwave reaction: Weigh 40g shrimp shell raw material powder and put it into a microwave reactor, add 4.67g diammonium hydrogen phosphate and 4.07g ammonium dihydrogen phosphate and 2.5L deionized water, stir well, and oxidize with 15wt% hydroxide The pH value of the sodium solution is adjusted to 12.0, the reaction temperature is controlled at 100°C by adjusting the microwave reaction power of 500w, and the reaction time is 2h. The product after the microwave reaction is washed with deionized water and dried to obtain nano-hydroxyapatite-chitosan Powder 15.9876g.

[0036] (3) product separation: the 15.9876g nano-hydroxyapatite-chitosan powder body that step (2) obtains is added deionized water, slowly adds the dilute hydrochloric acid of 15wt% while stirring at room temperature and adjusts the pH value to be 6.5, in After stirring at room temperatur...

Embodiment 3

[0039] (1) Crab shell pretreatment: directly dry the crab shell and pulverize it into powder for later use.

[0040] (2) Microwave reaction: Weigh 40g crab shell raw material powder and put it into a microwave reactor, add 6.34g diammonium hydrogen phosphate and 5.52g ammonium dihydrogen phosphate and 2.5L deionized water, stir well, and oxidize with 5wt% hydroxide The pH value of the sodium solution is adjusted to 8.0, the reaction temperature is controlled at 90°C by adjusting the microwave reaction power of 400w, and the reaction time is 8h. The product after the microwave reaction is washed with deionized water and dried to obtain nano-hydroxyapatite-chitosan Powder 18.9652g.

[0041] (3) product separation: the 18.9652g nano-hydroxyapatite-chitosan powder body that step (2) obtains is added deionized water, slowly adds the dilute hydrochloric acid of 5wt% while stirring at room temperature and adjusts the pH value to 4.0, in After stirring at room temperature for 6 hours...