Molecularly-imprinted polymer, preparation method therefor and application thereof
A molecular imprinting and polymer technology, applied in the field of analytical chemistry, can solve the problems of impurity interference detection, low specificity of adsorbents, etc., and achieve the effect of high recovery rate and strong specificity
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Embodiment 1
[0036]Dissolve Diludine0.5mmol, MMA2mmol, EDMA10mmol, AIBN0.05mmol in 20mmol acetonitrile, mix well in a round bottom flask and ultrasonically pre-act for 0.5h in an ice-water bath; feed nitrogen into the reactant mixture in the round bottom flask, After 10 minutes, use a rubber stopper to seal, and react in an oil bath at 60°C for 24 hours to obtain a polymer product; grind the polymer product, rinse with acetone to remove fine particles, and sieve to make the particle size of the polymer product 20-200 μm; use 200 mL of formic acid in methanol The solution (1:10, V:V) is the extractant. Soxhlet extraction takes 24 hours to remove the template molecules, and the extractant is added once at about 12 hours in the middle. After the extraction, wash with 100mL methanol to remove residual formic acid; The polymer was vacuum-dried at 60° C. for 12 hours to obtain 2,6-dimethyl-3,5-dicarboethoxy-1,4-dihydropyridine molecularly imprinted polymer (Diludine-MIP).
[0037] The infrared s...
Embodiment 2
[0039] Dissolve Diludine1mmol, MMA2mmol, EDMA10mmol, AIBN0.1mmol in 20mmol acetonitrile, mix well in a round-bottomed flask and ultrasonically pre-act for 1h in an ice-water bath; blow nitrogen into the reactant mixture in the round-bottomed flask, and use it after 10min Seal the rubber stopper, react in an oil bath at 60°C for 24 hours to obtain a polymer product; grind the polymer product, rinse with acetone to remove fine particles, and sieve to make the particle size of the polymer product 20-200 μm; use 200 mL of formic acid in methanol solution (1 :10, V:V) as the extractant, Soxhlet extraction for 24 hours to remove the template molecule, adding the extractant once at about 12 hours in the middle, washing with 100mL methanol after extraction to remove residual formic acid; Vacuum-dried at 60°C for 12 hours to obtain 2,6-dimethyl-3,5-dicarboethoxy-1,4-dihydropyridine molecularly imprinted polymer (Diludine-MIP).
Embodiment 3
[0041] Dissolve Diludine1mmol, MMA4mmol, EDMA15mmol, AIBN0.2mmol in 30mmol dichloromethane, mix well in a round-bottomed flask and ultrasonically pre-act for 1h in an ice-water bath; blow nitrogen into the reactant mixture in the round-bottomed flask for 10min Finally, use a rubber stopper to seal, and react in an oil bath at 60°C for 24 hours to obtain a polymer product; grind the polymer product, rinse with acetone to remove fine particles, and sieve to make the particle size of the polymer product 20-200 μm; use 200 mL of methanol solution of formic acid (1:10, V:V) is the extractant. Soxhlet extraction takes 24 hours to remove the template molecules, and the extractant is added once at about 12 hours in the middle. After the extraction is completed, wash with 100mL methanol to remove residual formic acid; The material was vacuum-dried at 60° C. for 12 hours to obtain 2,6-dimethyl-3,5-dicarboethoxy-1,4-dihydropyridine molecularly imprinted polymer (Diludine-MIP).
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