Fenbendazole liposome preparation and preparing method thereof
A technology of fenbendazole lipid and fenbendazole, which is applied in the field of new preparations of fenbendazole, can solve the problems of short elimination half-life, frequent medication, etc., to improve quality and curative effect, improve bioavailability, retain long time effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0017] A fenbendazole liposome preparation is prepared from the following raw materials in parts by weight: 1 part of fenbendazole, 10-90 parts of soybean lecithin, and 5-40 parts of cholesterol.
[0018] The preparation method of fenbendazole liposome preparation as described above, comprises the following steps:
[0019] (1) Mix soybean lecithin and cholesterol, add absolute ethanol, add 7 to 14 mL of absolute ethanol for every 100 mg of soybean lecithin and cholesterol, place in a water bath at 65 to 70 ° C, stir to dissolve, and remove the solvent under reduced pressure to obtain Phospholipid membrane;
[0020] (2) Add 100-200mmol / L phosphate buffer solution to fenbendazole, add 10-15mL phosphate buffer solution per mg of fenbendazole, stir to make fenbendazole solution, place at 65 ~70°C water bath, keep warm, and set aside;
[0021] (3) Take the preheated fenbendazole solution obtained in step (2), add the phospholipid film obtained in step (1), stir and hydrate in a w...
Embodiment 2
[0023] A fenbendazole liposome preparation is prepared from the following raw materials in parts by weight: 1 part of fenbendazole, 50 parts of soybean lecithin, and 25 parts of cholesterol.
[0024] The preparation method of fenbendazole liposome preparation as described above, comprises the following steps:
[0025] (1) Weigh 100mg of soybean lecithin and 50mg of cholesterol, mix them, add 20ml of absolute ethanol, place in a 65°C water bath, stir to dissolve, remove the solvent under reduced pressure, and obtain a phospholipid film;
[0026] (2) Weigh 2mg of fenbendazole and add 20ml of 0.1mol / L phosphate buffered saline water, stir to make a fenbendazole solution, put it in a 70°C water bath, keep warm, and set aside;
[0027] (3) Take the preheated fenbendazole solution, add it to a beaker containing phospholipids and cholesterol lipid film, stir and hydrate in a water bath at 65°C for 10 minutes; then place the beaker on a magnetic stirrer, stir at room temperature for 3...
Embodiment 3
[0029] A fenbendazole liposome preparation is prepared from the following raw materials in parts by weight: 1 part of fenbendazole, 60 parts of soybean lecithin, and 20 parts of cholesterol.
[0030] The preparation method of fenbendazole liposome preparation as described above, comprises the following steps:
[0031] (1) Mix 300mg soybean lecithin and 100mg cholesterol, add 50ml absolute ethanol, place in a 65°C water bath, stir to dissolve, and remove the solvent under reduced pressure to obtain a phospholipid film;
[0032] (2) Weigh 5mg of fenbendazole and add 60ml of 0.1mol / L phosphate buffered saline water, stir to make a fenbendazole solution, put it in a 70°C water bath, keep warm, and set aside;
[0033] (3) Take the preheated fenbendazole solution, add it to a beaker containing phospholipids and cholesterol lipid film, stir and hydrate in a water bath at 65°C for 15 minutes. Then place the beaker on a magnetic stirrer, stir at room temperature for 45 minutes, mix we...
PUM
| Property | Measurement | Unit |
|---|---|---|
| encapsulation rate | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More