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Double-layer sustained release tablet treating allergic rhinitis and preparation method thereof

A technology for allergic rhinitis and sustained-release tablets, which can be used in allergic diseases, pill delivery, respiratory diseases, etc. It can solve problems such as poor efficacy, relieve nasal congestion symptoms, reduce adverse reactions, and improve drug absorption.

Inactive Publication Date: 2016-01-13
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although antihistamines are effective in treating seasonal allergic rhinitis, they are less effective for nasal congestion common to allergic rhinitis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A double-layer sustained-release tablet for the treatment of allergic rhinitis, comprising an immediate-release layer and a sustained-release layer; raw materials in the immediate-release layer by weight, 60 parts of fexofenadine hydrochloride, 50-70 parts of microcrystalline cellulose 20-40 parts of croscarmellose sodium, 10 parts of croscarmellose sodium, and 1-5 parts of magnesium stearate; 120 parts, 20-30 parts of stearic acid, 100-200 parts of hypromellose, 1-5 parts of magnesium stearate.

Embodiment 2

[0026] The raw materials in the quick-release layer are in optimal parts by weight, 60 parts of fexofenadine hydrochloride, 50 parts of microcrystalline cellulose, 30 parts of croscarmellose sodium, and croscarmellose sodium 10 parts, 1 part of magnesium stearate.

Embodiment 3

[0028] The raw materials in the sustained-release layer include 120 parts of pseudoephedrine hydrochloride, 20 parts of stearic acid, 200 parts of hypromellose, and 1 part of magnesium stearate in optimal parts by weight.

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PUM

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Abstract

The invention discloses a double-layer sustained release tablet treating allergic rhinitis. The double-layer sustained release tablet is prepared from fexofenadine hydrochloride and pseudoephedrine hydrochloride, fexofenadine hydrochloride and pseudoephedrine hydrochloride are combined for use, the allergic rhinitis can be effectively treated, nasal congestion can be effectively removed, and the rhinobyon symptom is relieved. Meanwhile, the double-layer gel skeleton sustained release technology is adopted, a fast release layer fast releases fexofenadine hydrochloride in a fast disintergration mode, and the effect can be fast achieved; a slow release layer slowly releases pseudoephedrine hydrochloride for 12 hours, stable blood concentration can be kept, and bad reactions are reduced; the number of taking times is reduced, and patient compliance is enhanced; the drug release time is prolonged, drug adsorption is improved, and bioavailability can be improved easily.

Description

technical field [0001] The invention relates to the field of chemical drug sustained-release preparations, in particular to a double-layer sustained-release tablet for treating allergic rhinitis and a preparation method thereof. Background technique [0002] Seasonal allergic rhinitis is caused by tree, grass pollen, etc. Among them, ragweed pollen is the most common allergen, affecting 75% of allergic rhinitis patients. Antihistamine therapy is the main treatment for such diseases, and histamine H1 receptor antagonists have become the main drugs for the treatment of such diseases. Fexofenadine hydrochloride has a good antihistamine H1 receptor effect. It belongs to the third-generation antihistamine without sedative effect and is used for the treatment of chronic idiopathic urticaria and seasonal allergic rhinitis. Although antihistamines are effective in treating seasonal allergic rhinitis, they are less effective in treating nasal congestion, a common symptom of allergic...

Claims

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Application Information

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IPC IPC(8): A61K9/24A61K31/445A61K47/38A61K47/12A61P11/02A61P37/08A61K31/137
Inventor 马玉国张昕任萃文江延辉马凌风王海涛
Owner HARBIN SHENGJI PHARMA
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