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Cartilage tissue repair membrane and preparation method thereof

A cartilage tissue and membrane fiber technology, which is applied in the field of cartilage tissue repair membranes and its preparation, can solve the problems of long preparation period, complicated preparation method and high preparation cost, and achieve the effect of low cost, simple preparation method and short time consumption

Inactive Publication Date: 2016-01-13
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention: In order to solve the problems of complicated preparation method, high preparation cost and long preparation period of the cartilage tissue repair material in the prior art, the present invention provides a cartilage tissue repair membrane and its preparation method

Method used

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  • Cartilage tissue repair membrane and preparation method thereof

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Effect test

Embodiment 1

[0023] A cartilage tissue repair film, which is mainly made of the following raw materials in proportion by weight: 25 parts of collagen, 13 parts of aminodextran, 11 parts of hyaluronic acid, 8 parts of chitosan, 4 parts of fibronectin, Keratin 10 parts, membrane fiber 5 parts, sorbitol 14 parts, sodium lauryl sulfate 10 parts, cellulose gum 14 parts, benzyl alcohol 10 parts, double distilled water 35 parts.

[0024] A method for preparing a cartilage tissue repair membrane, comprising the following steps:

[0025] (1) Dissolve sorbitol, hyaluronic acid, sodium lauryl sulfate and benzyl alcohol in double distilled water, stir well and place in a constant temperature water bath at 32°C; add collagen, fibronectin and keratin to it, Stir until completely dissolved;

[0026] (2) Put aminodextran, chitosan, membrane fiber and cellulose gum in a reaction kettle, make a melt at a temperature of 380°C and a pressure of 1.9MPa, and dry and pulverize it to produce Powder, particle si...

Embodiment 2

[0030] A cartilage tissue repair film, mainly made of the following raw materials according to the weight ratio: 42 parts of collagen, 23 parts of aminodextran, 21 parts of hyaluronic acid, 19 parts of chitosan, 13 parts of fibronectin, 28 parts of keratin, 13 parts of membrane fiber, 23 parts of sorbitol, 22 parts of sodium lauryl sulfate, 33 parts of cellulose gum, 21 parts of benzyl alcohol, 55 parts of double distilled water.

[0031] A method for preparing a cartilage tissue repair membrane, comprising the following steps:

[0032] (1) Dissolve sorbitol, hyaluronic acid, sodium lauryl sulfate and benzyl alcohol in double distilled water, stir well and place in a constant temperature water bath at 36°C; add collagen, fibronectin and keratin to it, Stir until completely dissolved;

[0033] (2) Put aminodextran, chitosan, membrane fiber and cellulose gum in a reaction kettle, make a melt at a temperature of 430°C and a pressure of 3.5MPa, and dry and pulverize it to produce...

Embodiment 3

[0037] A cartilage tissue repair film, which is mainly made of the following raw materials in proportion by weight: 50 parts of collagen, 28 parts of aminodextran, 24 parts of hyaluronic acid, 24 parts of chitosan, 14 parts of fibronectin, Keratin 32 parts, membrane fiber 15 parts, sorbitol 26 parts, sodium lauryl sulfate 25 parts, cellulose gum 36 parts, benzyl alcohol 26 parts, double distilled water 65 parts.

[0038] A method for preparing a cartilage tissue repair membrane, comprising the following steps:

[0039] (1) Dissolve sorbitol, hyaluronic acid, sodium lauryl sulfate and benzyl alcohol in double distilled water, stir well and place in a constant temperature water bath at 37°C; add collagen, fibronectin and keratin to it, Stir until completely dissolved;

[0040] (2) Put aminodextran, chitosan, membrane fiber and cellulose gum in a reaction kettle, make a melt at a temperature of 490°C and a pressure of 3.7MPa, dry and pulverize Powder, particle size is 1300 mesh...

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Abstract

The invention discloses a cartilage tissue repair membrane and a preparation method thereof. The cartilage tissue repair membrane is mainly made from, by weight: 25-50 parts of collagen, 13-28 parts of glycosaminoglycans, 11-24 parts of hyaluronic acid, 8-24 parts of chitosan, 4-14 parts of fibronectin, 10-32 parts of keratin, 5-15 parts of membrane fiber, 14-26 parts of sorbitol, 10-25 parts of sodium lauryl sulfate, 14-36 parts of cellulose gum, 10-26 parts of benzyl alcohol, and 35-65 parts of double distilled water. Compared with the prior art, the invention has the advantages that the prepared cartilage tissue repair membrane has water content 60-80% and meets the requirement for repairing human cartilage tissues; the preparation method of the cartilage tissue repair membrane is simple, quick and low in cost.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a cartilage tissue repair membrane and a preparation method thereof. Background technique [0002] Cartilage tissue is composed of collagen tissue, a few cells, and 60-80% water. Adult cartilage tissue has no blood vessels or nerves, so the ability of cartilage tissue to repair itself after injury is limited. [0003] The end of each bone is covered by a layer of cartilage tissue. These cartilage tissues can prevent friction and impact between bones. [0004] Since the 1990s, the emergence of cartilage tissue engineering has enabled humans to artificially build hyaline cartilage in vitro and in vivo, providing a promising method for the repair of articular cartilage defects. Cartilage tissue engineering is an edge science that combines engineering and biomedicine, especially cell biology. It involves three basic elements: cells, scaffold materials, and a developmental enviro...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/20A61L27/22A61L27/50
Inventor 金仲恩全春兰张帆喻国贞欧阳智琨陈晋纳
Owner SUZHOU COSMETIC MATERIALS
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