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A kind of antibacterial Chinese herbal medicine compound prescription for fish and its preparation method and application

A Chinese herbal medicine composition and technology for fish, applied in the direction of antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the quality and safety problems of aquatic products, and achieve good anti-streptococcal effect, compact combination, The effect of simple production method

Active Publication Date: 2019-07-19
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical drugs have been mainly used to prevent and treat various bacterial diseases including streptococcal disease. However, frequent use of chemical drugs not only induces the emergence of drug-resistant pathogenic strains, but also causes problems in the quality and safety of aquatic products due to drug residues.

Method used

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  • A kind of antibacterial Chinese herbal medicine compound prescription for fish and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Drying the raw materials in an oven at 55°C, pulverizing them, and passing through a 40-mesh sieve to obtain dry powders of the raw materials;

[0045] (2) Mix the dry powders of the raw materials obtained in step (1) uniformly by the following weights: 70 g of Galla galla, 180 g of Green Fruit, 150 g of pomegranate peel, 50 g of Mildew Spatholobus, and 50 g of Water Wenghua, soak in 7.5 liters of water at 60 ° C, and Keep at 60°C for 2 hours, then heat to boiling, then decoct with slow fire for 50 minutes, filter with 3 layers of gauze, then filter with sieve silk, add 7.5 liters of water to the medicine residue, heat to boiling, then decoct with slow fire for 45 minutes, use the previous method Filtrate, combine twice filtrate, obtain filtrate A;

[0046] (3) The filtrate A is boiled and concentrated to 2 liters, which is a compound liquid preparation of antibacterial Chinese herbal medicine for fish.

[0047] The Galla galla in this embodiment is produced in Sic...

Embodiment 2

[0049] (1) drying the raw materials in an oven at 60° C., pulverizing them, and passing through a 50-mesh sieve to obtain dry powders of the raw materials;

[0050](2) Mix the dry powders of the raw materials obtained in step (1) uniformly by the following weights: gallnut 100g, green fruit 100g, pomegranate peel 150g, Caulis Spatholobus 75g, water wenghua 75g, put into 15 liters of 70 ℃ of water and soak, keep 70°C for 100 minutes, then heated to boiling, then simmered for 55 minutes, filtered through 3 layers of gauze, then filtered with sieve silk, added 15 liters of water to the medicine residue, heated to boiling, then simmered for 40 minutes, using the previous method Filtrate, combine twice filtrate, obtain filtrate A;

[0051] (3) The filtrate A is boiled and concentrated to 2 liters, which is a compound liquid preparation of antibacterial Chinese herbal medicine for fish.

Embodiment 3

[0053] (1) Drying the raw materials in an oven at 65°C, pulverizing them, and passing through a 60-mesh sieve to obtain dry powders of the raw materials;

[0054] (2) Mix the dry powders of the raw materials obtained in step (1) uniformly by the following weights: 80 g of Galla galla, 200 g of Green Fruit, 150 g of pomegranate peel, 40 g of Mildew Spatholobus, and 30 g of Water Wenghua, put into 10 liters of 80° C. water for soaking, keep 80°C for 60 minutes, then heated to boiling, then simmered for 50 minutes, filtered through 3 layers of gauze, then filtered with sieve silk, added 10 liters of water to the medicine residue, heated to boiling, then simmered for 45 minutes, using the previous method Filtrate, combine twice filtrate, obtain filtrate A;

[0055] (3) The filtrate A is boiled and concentrated to 2 liters, which is a compound liquid preparation of antibacterial Chinese herbal medicine for fish.

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Abstract

The invention discloses an antibacterial Chinese herbal medicine compound for fishes as well as a preparation method and application of the antibacterial Chinese herbal medicine compound. The Chinese herbal medicine compound is prepared from the following crude drugs in percentage by weight: 10-20% of Chinese galls, 20-40% of immature fruits of trminalia chebula, 10-30% of pomegranate barks, 8-20% of suberect spatholobus stems and 6-20% of water banyan flowers. The crude drugs are compact in combination, the production method is simple and convenient, and the medication cost is not high. The antibacterial Chinese herbal medicine compound disclosed by the invention is capable of effectively inhibiting and killing various aquatic pathogenic bacteria, has a particularly good streptococcus-resistant effect and is an ideal safe and green oral administration product for preventing and treating bacterial diseases of fishes and particularly streptococcal diseases of tilapia mossambica; and the product is degradable and residue-free in environments and fish bodies, so that the quality safety of water environments and aquatic products can be ensured, and meanwhile, the condition that pathogenic bacteria are induced to generate drug-resistant strains is avoided.

Description

technical field [0001] The invention belongs to the field of aquaculture, and in particular relates to a fish antibacterial (especially streptococcus) Chinese herbal medicine compound and a preparation method and application thereof. Background technique [0002] Bacterial disease is an important disease of farmed fish, among which, streptococcus causes a large number of tilapias to die, causing huge economic losses. Prevention and treatment of fish bacterial diseases (including tilapia streptococcosis) is essential to ensure the healthy development of fish farming industry few measures. Chemical drugs have been mainly used to prevent and control various bacterial diseases including streptococcal disease. However, frequent use of chemical drugs not only induces the emergence of drug-resistant pathogenic strains, but also causes quality and safety problems of aquatic products due to drug residues. Chinese herbal medicine has low toxicity, low residue, small side effects, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/61A61P31/04A61K35/64
Inventor 张其中华亚南
Owner JINAN UNIVERSITY
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