Preparation method of paracetamol, aminophenazone, caffeine and chlorphenamine maleate tablet

A technology of phenamine and caffeine, which is applied in the field of medicine and chemical industry, can solve the problems of inconsistent softness and hardness of granules, uneven compound raw materials, etc., and achieve the effect of ensuring quality, ensuring uniformity, and simple operation process

Inactive Publication Date: 2016-02-03
LINFEN BAOZHU PHARMA
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method often has the problem that the compound raw materials in the acetaminophen and aminopyrine granules are not uniform, and the softness and hardness of the two granules are inconsistent.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A preparation method for pheniramine tablets, comprising the steps of: weighing 30 parts of paracetamol, 20 parts of aminopyrine, 7 parts of caffeine, 0.4 part of chlorpheniramine maleate, and placing them in a mixer Add 5 parts of microcrystalline cellulose, 3 parts of dextrin, and 2 parts of hydroxypropyl cellulose, and mix well; use the mixed material to extrude into tablets in a dry extruder, break the tablets into granules, and then add 5 parts of pregelatinized starch, 2 parts of magnesium stearate, 2 parts of carboxymethyl starch sodium, mix evenly, and press twice.

Embodiment 2

[0014] A preparation method for pheniramine tablets, comprising the steps of: weighing 30 parts of paracetamol, 20 parts of aminopyrine, 7 parts of caffeine, 0.4 part of chlorpheniramine maleate, and placing them in a mixer Add 5 parts of microcrystalline cellulose, 3 parts of dextrin, and 2 parts of hydroxypropyl cellulose, and mix well; use the mixed material to extrude into tablets in a dry extruder, break the tablets into granules, and then add 7 parts of pregelatinized starch, 1 part of magnesium stearate, 2 parts of carboxymethyl starch sodium, mix well, and press twice.

Embodiment 3

[0016] A preparation method for pheniramine tablets, comprising the steps of: weighing 30 parts of paracetamol, 20 parts of aminopyrine, 7 parts of caffeine, 0.4 part of chlorpheniramine maleate, and placing them in a mixer Add 5 parts of microcrystalline cellulose, 3 parts of dextrin, and 2 parts of hydroxypropyl cellulose, and mix well; use the mixed material to extrude into tablets in a dry extruder, break the tablets into granules, and then add 8 parts of pregelatinized starch, 2 parts of magnesium stearate, 3 parts of carboxymethyl starch sodium, mix evenly, and press twice.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method of a paracetamol, aminophenazone, caffeine and chlorphenamine maleate tablet, and belongs to the technical field of pharmaceutical chemical engineering. The preparation method has a simple technology, can evenly mix paracetamol, aminophenazone, and various raw materials, and is capable of avoiding the phenomenon of mutual dissolution between paracetamol and aminophenazone. The preparation method comprises the following steps: weighing paracetamol, aminophenazone, caffeine and chlorphenamine maleate according to a certain ratio, adding the components into a mixing machine, adding microcrystalline cellulose, dextrin, and hydroxypropyl cellulose, evenly mixing; pressing the evenly-mixed materials into tablets in a dry pressing machine, then grinding the tablets into particles, adding pre-gelatinized starch, magnesium stearate, and sodium carboxyl methyl starch, evenly mixing, and pressing the mixture into tablets for a second time.

Description

technical field [0001] The invention relates to a preparation method of phenammonate tablet, which belongs to the technical field of medicine and chemical industry. Background technique [0002] Phenaminocarbamin Tablets is a general medicine, mainly used for colds, fever, headache, neuralgia and rheumatism, etc. Acetaminophen and aminopyrine are the relapse raw materials specified in the prescription, and both are indispensable. However, acetaminophen and aminopyrine can not be put together because of their respective physical properties, as long as they are together when they are wet and heated or add adhesives, they will co-dissolve. [0003] At present, the preparation method of phenammonate tablets is generally to separately granulate acetaminophen and aminopyrine, and then mix them, so as to realize the purpose that acetaminophen and aminopyrine will not co-dissolve. However, this method often has the problems of inhomogeneous compound raw materials in acetaminophen ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/522A61K9/20A61P11/00A61P31/00A61P29/00A61P25/04A61K31/4402A61K31/4152A61K31/167
Inventor 董隰生
Owner LINFEN BAOZHU PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap