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Bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins

A technology of freeze-dried preparations and fat-soluble vitamins, which is applied in the direction of freeze-dried delivery, drug combination, active ingredients of hydroxyl compounds, etc., to achieve the effects of avoiding side effects, avoiding pollution risks, and improving stability

Active Publication Date: 2015-02-11
XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The new multivitamin freeze-dried preparation effectively solves the problem of co-dissolution of fat-soluble and water-soluble vitamins, improves the stability of vitamins, reduces the decomposition of drugs, and the side effects caused by decomposition products; it eliminates the need for traditional 2-bottle preparations in use Pollution risks that may be caused by time; at the same time, it can ensure the full dissolution of drug compounds, avoiding the side effects of insoluble substances on the body.

Method used

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  • Bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins
  • Bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins
  • Bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins

Examples

Experimental program
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Effect test

example 1

[0098] Example 1 A bottle of lipid microemulsion compounded with 13 kinds of vitamin freeze-dried preparations prepared with different proportions of phospholipid emulsifier content

example 11

[0099] Example 1.1 Prescription:

[0100]

[0101] Preparation:

[0102] (1) Dissolve the vitamin A, vitamin D, vitamin E, and vitamin K in the above prescription amount in soybean oil in a 60°C water bath under the protection of nitrogen. After the dissolution is complete, add the prescribed amount of egg yolk lecithin, and continue stirring until dissolved. Then add the prescribed amount of poloxamer and polyethylene glycol-cephalin derivatives, and continue to stir and dissolve until the solution is clear to form an oil phase mixture. At the same time, dissolve the prescribed amount of sodium oleate and water for injection in a 60°C water bath to completely form a water phase mixture, then slowly add the water phase mixture to the oil phase mixture to form colostrum, and then place the colostrum in a high-speed shearing machine Shear at 14000rpm for 10min, and finally place in a high-pressure homogenizer to homogenize 10 times under the pressure of 1250 bar to obtain a ...

example 12

[0105] Example 1.2 Prescription:

[0106]

[0107] Preparation:

[0108](1) Dissolve the vitamin A, vitamin D, vitamin E, and vitamin K in the above prescription amount in soybean oil in a 60°C water bath under the protection of nitrogen. After the dissolution is complete, add the prescription amount of soybean lecithin, and continue stirring to dissolve until dissolved Then add the prescribed amount of poloxamer and polyethylene glycol-cephalin derivatives, and continue to stir and dissolve until the solution is clear to form an oil phase mixture. At the same time, dissolve the prescribed amount of sodium oleate and water for injection in a 60°C water bath to completely form a water phase mixture, then slowly add the water phase mixture to the oil phase mixture to form colostrum, and then place the colostrum in a high-speed shearing machine Shear at 14000rpm for 10min, and finally place in a high-pressure homogenizer and homogenize 12 times at a pressure of 1250 bar to ob...

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Abstract

The invention discloses a bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins. The preparation is prepared by wrapping lipid-soluble vitamins A, D, E and K in grease micro emulsion of which the particle size is smaller than 120nm, mixing with water-soluble vitamins B and C, folic acid, nicotinamide and the like, adding a freeze-drying forming agent and a redissolution additive, and freeze-drying. The novel freeze-dried preparation, which contains 13 vitamins and is developed according to the above formula and the preparation method, is simple in process, the stability of the vitamins can be improved, and the side effect caused by medicine decomposition and decomposition products is alleviated; the problem of codissolution of lipid-soluble vitamins and water-soluble vitamins is effectively solved, sufficient dissolution of medicine compounds is ensured, and the side effect of undissolved substances on human bodies is avoided.

Description

technical field [0001] The invention belongs to the technical field of medical drugs, and relates to a pharmaceutical preparation for preventing and treating vitamin deficiency and a preparation method thereof. To be precise, it is a lyophilized preparation of 13 kinds of vitamins compounded with lipid microemulsion in a bottle. The new preparation cleverly combines water-soluble and fat-soluble vitamins with a special formula and process to form a co-soluble single freeze-dried compound. It can improve the stability of vitamins, reduce the decomposition of drugs, and the side effects caused by decomposition products; effectively solve the problem of co-dissolution of fat-soluble and water-soluble vitamins, and avoid the possibility of repeated extraction-mixing of traditional 2-pack preparations during use. Pollution risk; at the same time, it can ensure the full dissolution of pharmaceutical compounds, avoiding the side effects of insoluble substances on the body. It is su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K9/19A61P3/02A61K31/59A61K31/519A61K31/455A61K31/525A61K31/51A61K31/4415A61K31/4188A61K31/375A61K31/355A61K31/07A61K31/05
CPCA61K9/0019A61K9/19A61K31/07A61K31/122A61K31/164A61K31/355A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/593A61K31/714A61K2300/00
Inventor 马玉樊陈涛惠民权张婉直王汝涛余惟平
Owner XIAN LIBANG ZHAOXIN BIOTECH CO LTD
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