Anti-cancer pharmaceutical composition and application thereof in preparation of anti-cancer medicines
A technology of anti-cancer drugs and compositions, applied in the field of preparation of anti-cancer drugs, can solve the problems of not meeting clinical needs, less research on anti-tumor, weak pharmacological activity, etc., and achieve significant synergistic inhibitory effect and good synergistic effect Action, little side effects
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Embodiment 1
[0036] Preparation of total flavonoids extract from Sophora japonicus
[0037] Picking and processing: Wash the Huaijiao harvested in autumn (the Chinese Huaijiao collected from Shijiazhuang area between September 15th and October 15th) with tap water, absorb the water, and dry at 60°C for later use. Sophora japonica in autumn is flat cylindrical, about 1-6cm long, 0.6-1cm in diameter, some are slightly curved, the seeds are constricted into beads, and the color is green or yellow-green. The pulp is soft, juicy and sticky. There are seeds in different numbers, about 1 to 6, the seeds are about 8-10mm long, 5-8mm wide, and about 5mm thick, plump and smooth, light yellow, kidney-shaped, with an oval hilum on one side, and an oval hilum on the other side. There is a round micropyle, and there is a slightly raised seed ridge on the other side. Comparing the average wet weight and dry weight of individual Sophora japonica with winter Sophora japonica, and examining its maturity, ...
Embodiment 5
[0052] In Vitro Antitumor Test
[0053] 1) Test material
[0054] Test drug: the composition of the total flavonoids extract of Sophora japonicus prepared in Example 1 and 5-fluorouracil in different ratios.
[0055] Preparation of the test drug: take 0.25 g of 5-fluorouracil and dilute it with 10 mL of DMEM medium containing 10% FBS to 1.9 × 10 -1 mol / L, then diluted to 2.5×10 with the same medium -5 mol / L~2.5×10 -7 mol / L, for experiments.
[0056] Cell lines: human esophageal cancer cell (Eca-109) and liver cancer cell (SMMC-7721) strains were purchased from the Cancer Institute of Hebei Medical University; breast cancer cell line (MDA-MB-231) was purchased from the Basic Medicine of Peking Union Medical College Research Institute Cell Center; breast cancer cell line (MCF-7) was donated by the Laboratory Department of Bethune International Peace Hospital;
[0057] Reagents and instruments: 10% fetal bovine serum (FBS, product of Hyclone Company); penicillin (Sigma, USA)...
Embodiment 6
[0065] Tablets are prepared according to methods known in the art, and each tablet (500 mg) contains the following ingredients:
[0066]
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