Pharmaceutical composition containing glimepiride and metformin hydrochloride
A technology of metformin hydrochloride and glimepiride, which is applied in the field of medicine and can solve the problems of unsatisfactory tablet splitability and the like
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Embodiment 1
[0020] Example 1 Pharmaceutical compositions of the present invention are prepared.
[0021] Take 10.0g of povidone K25, dissolve it in an appropriate amount of purified water, and prepare it as a binding solution; take 2.0g of glimepiride, 50.0g of mannitol, and 10.0g of croscarmellose sodium, mix well, and add the binding solution Liquid granulation, drying the wet granules at 60°C, passing through a 20-mesh sieve for granulation to obtain glimepiride granules.
[0022] Take 500.0 g of metformin hydrochloride and 16.0 g of povidone K25, mix them evenly, add an appropriate amount of purified water to granulate, dry the wet granules at 60° C., pass through a 20-mesh sieve for granulation, and obtain metformin hydrochloride granules.
[0023] Take 55.0 g of microcrystalline cellulose and 12.0 g of crospovidone, mix them with the above-prepared glimepiride granules and metformin hydrochloride granules, and then add 5.0 g of magnesium stearate for total blending to obtain a tot...
Embodiment 2
[0025] Example 2 Pharmaceutical compositions of the present invention are prepared.
[0026] Take 6.5g of high-substituted hydroxypropyl cellulose, dissolve it in an appropriate amount of purified water, and prepare a binding solution; take 2.0g of glimepiride, 48.5g of lactose, and 15.0g of sodium carboxymethyl starch, mix well, and add to the binding solution For granulation, dry the wet granules at 60°C, pass through a 24-mesh sieve for granulation, and obtain glimepiride granules.
[0027] Take 500.0g of metformin hydrochloride, 48.0g of microcrystalline cellulose, and 20.0g of hydroxypropylmethylcellulose, mix them evenly, add an appropriate amount of purified water to granulate, dry the wet granules at 60°C, pass through a 24-mesh sieve for granulation, and prepare Obtain metformin hydrochloride granules.
[0028] Take 15.0 g of low-substituted hydroxypropyl cellulose, mix with the above-prepared glimepiride granules and metformin hydrochloride granules, and then add...
Embodiment 3
[0030] Example 3 Pharmaceutical compositions of the present invention are prepared.
[0031] Take 3.0g of hydroxypropylmethylcellulose, dissolve in an appropriate amount of purified water, and prepare a binding solution; take 2.0g of glimepiride, 35.0g of lactose, and 20.0g of mannitol, mix well, add the binding solution to granulate, and The wet granules were dried at 60°C, passed through a 20-mesh sieve, and sized to obtain glimepiride granules.
[0032] Take 500.0g of metformin hydrochloride, 20.0g of microcrystalline cellulose, and 22.0g of hydroxypropylmethylcellulose, mix them evenly, add an appropriate amount of purified water to granulate, dry the wet granules at 60°C, pass through a 20-mesh sieve for granulation, and prepare Obtain metformin hydrochloride granules.
[0033] Take 40.0 g of microcrystalline cellulose and 12.0 g of sodium carboxymethyl starch, mix them with the glimepiride granules and metformin hydrochloride granules prepared above, and then add 5.0...
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