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Pharmaceutical composition containing glimepiride and metformin hydrochloride

A technology of metformin hydrochloride and glimepiride, which is applied in the field of medicine and can solve the problems of unsatisfactory tablet splitability and the like

Active Publication Date: 2018-06-01
HAINAN ZHONGJI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventors have found through research that although acceptable dissolution rate and stability can be obtained by adopting the tablet prepared by the invention, the divisibility of the tablet is unsatisfactory

Method used

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  • Pharmaceutical composition containing glimepiride and metformin hydrochloride
  • Pharmaceutical composition containing glimepiride and metformin hydrochloride
  • Pharmaceutical composition containing glimepiride and metformin hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Pharmaceutical compositions of the present invention are prepared.

[0021] Take 10.0g of povidone K25, dissolve it in an appropriate amount of purified water, and prepare it as a binding solution; take 2.0g of glimepiride, 50.0g of mannitol, and 10.0g of croscarmellose sodium, mix well, and add the binding solution Liquid granulation, drying the wet granules at 60°C, passing through a 20-mesh sieve for granulation to obtain glimepiride granules.

[0022] Take 500.0 g of metformin hydrochloride and 16.0 g of povidone K25, mix them evenly, add an appropriate amount of purified water to granulate, dry the wet granules at 60° C., pass through a 20-mesh sieve for granulation, and obtain metformin hydrochloride granules.

[0023] Take 55.0 g of microcrystalline cellulose and 12.0 g of crospovidone, mix them with the above-prepared glimepiride granules and metformin hydrochloride granules, and then add 5.0 g of magnesium stearate for total blending to obtain a tot...

Embodiment 2

[0025] Example 2 Pharmaceutical compositions of the present invention are prepared.

[0026] Take 6.5g of high-substituted hydroxypropyl cellulose, dissolve it in an appropriate amount of purified water, and prepare a binding solution; take 2.0g of glimepiride, 48.5g of lactose, and 15.0g of sodium carboxymethyl starch, mix well, and add to the binding solution For granulation, dry the wet granules at 60°C, pass through a 24-mesh sieve for granulation, and obtain glimepiride granules.

[0027] Take 500.0g of metformin hydrochloride, 48.0g of microcrystalline cellulose, and 20.0g of hydroxypropylmethylcellulose, mix them evenly, add an appropriate amount of purified water to granulate, dry the wet granules at 60°C, pass through a 24-mesh sieve for granulation, and prepare Obtain metformin hydrochloride granules.

[0028] Take 15.0 g of low-substituted hydroxypropyl cellulose, mix with the above-prepared glimepiride granules and metformin hydrochloride granules, and then add...

Embodiment 3

[0030] Example 3 Pharmaceutical compositions of the present invention are prepared.

[0031] Take 3.0g of hydroxypropylmethylcellulose, dissolve in an appropriate amount of purified water, and prepare a binding solution; take 2.0g of glimepiride, 35.0g of lactose, and 20.0g of mannitol, mix well, add the binding solution to granulate, and The wet granules were dried at 60°C, passed through a 20-mesh sieve, and sized to obtain glimepiride granules.

[0032] Take 500.0g of metformin hydrochloride, 20.0g of microcrystalline cellulose, and 22.0g of hydroxypropylmethylcellulose, mix them evenly, add an appropriate amount of purified water to granulate, dry the wet granules at 60°C, pass through a 20-mesh sieve for granulation, and prepare Obtain metformin hydrochloride granules.

[0033] Take 40.0 g of microcrystalline cellulose and 12.0 g of sodium carboxymethyl starch, mix them with the glimepiride granules and metformin hydrochloride granules prepared above, and then add 5.0...

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Abstract

The invention relates to a pharmaceutical composition containing glimepiride and metformin hydrochloride, which comprises glimepiride granules, metformin hydrochloride granules and extragranular excipients, wherein the glimepiride granules contain The binder with a urea weight ratio of 1.5-5:1, the metformin hydrochloride granules and / or extragranular excipients contain microcrystalline cellulose.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a pharmaceutical composition containing glimepiride and metformin hydrochloride. Background technique [0002] Glimepiride is the third-generation sulfonylurea antidiabetic drug, which can inhibit hepatic glucose synthesis, promote the uptake of peripheral glucose by muscle tissue and promote insulin secretion; metformin hydrochloride is a biguanide hypoglycemic drug with multiple effects Mechanisms include delaying glucose uptake from the gastrointestinal tract, increasing peripheral glucose utilization by improving insulin sensitivity, and inhibiting excessive gluconeogenesis in the liver and kidney. The combined application of glimepiride and metformin hydrochloride has a synergistic effect, and is suitable for patients whose blood sugar cannot be effectively controlled by single application of glimepiride or metformin hydrochloride. [0003] When diabetic patients take the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/64A61K9/20A61P3/10
Inventor 刘启兵杨贵方肖文礼章燕杨波
Owner HAINAN ZHONGJI MEDICAL TECH
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