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Eye mask for treating diabetic macular edema

A technology for macular edema and diabetic patients, applied in the field of medical preparations, can solve problems such as difficulty in exerting drug efficacy, difficulty in breaking through the blood-retinal barrier, etc. Effect

Active Publication Date: 2018-07-13
TIANJIN PHARMACN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides an eye mask that can assist in the treatment of macular edema in diabetic patients, and solve the problems in the prior art that it is difficult for external medicines to break through the blood-retinal barrier and exert their efficacy

Method used

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  • Eye mask for treating diabetic macular edema
  • Eye mask for treating diabetic macular edema
  • Eye mask for treating diabetic macular edema

Examples

Experimental program
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Effect test

Embodiment 1

[0028] An eye patch comprises medicine and a polylactic acid film loaded with medicine, the medicine is aspirin acceptable to diabetic retinopathy patients, the film is polylactic acid film, and the mass ratio of polylactic acid to aspirin is 8 / 3.

[0029] This eye patch is accomplished through the following steps:

[0030] Step 1: Ingredients: Weigh an appropriate amount of polylactic acid and aspirin respectively, crush and sieve, dry in vacuum, and place them in an airtight container.

[0031] Step 2: Mixing: Add polylactic acid to ethyl acetate, stir under airtight conditions to completely dissolve it into solution A, and adjust the pH of the solution to 6.3;

[0032] Step 3: Polymerization: add one of processed aspirin, 2,5-dihydroxybenzenesulfonate calcium hydrate, and dexamethasone to solution A, add a certain proportion of glycerin, dissolve it with ultrasonic waves, and react for 15 minutes. Ultrasonic degassing for 40 minutes to form drug membrane slurry B.

[0033...

Embodiment 2

[0037] An eye patch, comprising a drug and a drug-loaded polylactic acid film, the drug is 2,5-dihydroxybenzenesulfonate calcium-hydrate acceptable to diabetic retinopathy patients, the film is a polylactic acid film, the The mass ratio of polylactic acid to 2,5-dihydroxybenzenesulfonate calcium-hydrate is 2 / 1.

[0038] This eye patch is accomplished through the following steps:

[0039] Step 1: Ingredients: Weigh appropriate amounts of polylactic acid and calcium 2,5-dihydroxybenzenesulfonate-hydrate, crush and sieve, dry in vacuum, and place them in an airtight container.

[0040] Step 2: Mixing: Add polylactic acid to ethyl acetate, stir under airtight conditions to completely dissolve it into solution A, and adjust the pH of the solution to 6.8;

[0041] Step 3: Polymerization: Add processed calcium 2,5-dihydroxybenzenesulfonate-hydrate to solution A, add a certain proportion of glycerin, heat to 80°C with steam, dissolve, react for 20 minutes, water bath or ultrasonic de...

Embodiment 3

[0046] An eye patch, comprising a drug and a drug-loaded polylactic acid film, the drug is acceptable dexamethasone for diabetic retinopathy patients, the film is a polylactic acid film, one of the polylactic acid and dexamethasone The mass ratio of species is 80 / 1.

[0047] This eye patch is accomplished through the following steps:

[0048] Step 1: Ingredients: Weigh an appropriate amount of polylactic acid and dexamethasone, pulverize, sieve, dry in vacuum, and place in an airtight container.

[0049] Step 2: Mixing: Add polylactic acid to ethyl acetate, stir under airtight conditions to completely dissolve it into solution A, and adjust the pH of the solution to 7.5;

[0050] Step 3: Polymerization: add one of processed aspirin, 2,5-dihydroxybenzenesulfonate calcium-hydrate, and dexamethasone to solution A, add a certain proportion of glycerin, dissolve it with ultrasonic waves, and react for 20 minutes. Degassing in a water bath for 40 minutes to form drug membrane slur...

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Abstract

An eye mask for treating macular edema in diabetic patients, comprising medicine and polylactic acid film loaded with medicine, the medicine is acceptable aspirin, 2,5-dihydroxybenzenesulfonate calcium-hydrate, dexamethasone for diabetic retina patients A kind of metasone, the film is a polylactic acid film, the eye film is made through the steps of batching, mixing, polymerization, film making, disinfection, etc. It has no irritation to the eyes, and the average release rate of the drug in vitro within 3 hours can reach 83.4%, the treatment effect on macular edema is remarkable.

Description

technical field [0001] The invention relates to a medical preparation, in particular to an eye mask for treating diabetic macular edema. Background technique [0002] The blood-retinal barrier (BRB) includes an inner barrier composed of retinal capillary endothelial cells and their tight junctions, and an outer barrier composed of retinal pigment epithelial cells and their tight junctions. Under normal circumstances, the inner retinal barrier prevents the leakage of intravascular fluid and macromolecular substances to the retina; the outer barrier prevents the leakage of blood from the choroidal capillaries to the retina. Various reasons, such as ischemia, abnormal glucose metabolism, release of inflammatory cytokines, mechanical traction of vitreous body and epiretinal membrane, etc., can cause damage to the blood-retinal barrier, and leakage of intravascular fluid and macromolecular substances to the outside of the cell Gaps, forming retinal edema, edema that occurs in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/616A61K9/70A61K47/34A61P9/10A61P27/02A61K31/573A61K31/185
Inventor 张树伟
Owner TIANJIN PHARMACN MEDICAL TECH
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