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Fatty acid extract of rape pollen as well as preparation method and application of fatty acid extract

A technology of fatty acid extract and rapeseed pollen, which is applied in the direction of medical formula, drug combination, plant raw materials, etc., can solve the problems that cannot be completely cured, have many side effects, and cause liver and kidney damage, so as to prevent oxidation and escape, and produce Low cost, easy to refine effect

Inactive Publication Date: 2016-02-17
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many methods for treating benign prostatic hyperplasia at home and abroad, such as western medicine treatment, commonly used finasteride, tamsulosin hydrochloride and terazosin hydrochloride and other drugs for treatment, basically all have some curative effects, but they can only treat symptoms It cannot cure the root cause, and these medicines have many side effects, especially great damage to the liver and kidneys. They only relieve the symptoms and cannot achieve the purpose of a complete cure.

Method used

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  • Fatty acid extract of rape pollen as well as preparation method and application of fatty acid extract
  • Fatty acid extract of rape pollen as well as preparation method and application of fatty acid extract

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preparation example Construction

[0039] The preparation method of rape pollen fatty acid extract of the present invention comprises the following steps:

[0040] Step 1, extract rape pollen with water, retain the pollen solids obtained by water extraction and discard the liquid obtained by water extraction; the specific process of water extraction in step 1 is: adding 4-10 times the weight of water to the rape pollen, stirring at room temperature for 2-8h The pollen mixture is obtained; the pollen mixture is filtered and dried to obtain a filter residue, and the filter residue is dried under reduced pressure to obtain a pollen solid; or, the pollen mixture is centrifuged, the supernatant is removed, and the precipitate is dried under reduced pressure to obtain a pollen solid.

[0041] Step 2, put the pollen solid obtained in step 1 into supercritical CO 2 Extraction is carried out in the extraction device to obtain rape pollen supercritical extract; in step 2, supercritical CO 2 The specific process of extra...

Embodiment 1

[0045] Preparation of Rape Pollen Fatty Acid Extract:

[0046] Step 1: Weigh 500 g of rape pollen, add 4 times the weight of water to the rape pollen, stir at room temperature for 8 hours to obtain a pollen mixture; filter the pollen mixture to obtain a filter residue, and dry the filter residue under reduced pressure to obtain a pollen solid;

[0047] Step 2, put the pollen solid obtained in step 1 into supercritical CO 2 Extraction is carried out in an extraction device, the extraction temperature is 30°C, and the extraction pressure is 20Mpa; separation kettle I: pressure 4MPa, temperature 30°C; separation kettle II: pressure 4MPa, temperature 30°C; extraction time 1h to obtain rape pollen supercritical extract .

[0048] Step 3, add 20 times the weight of 50% (v / v) ethanol to the supercritical extract of rape pollen obtained in step 2, extract at 50° C. for 4 hours with airtight stirring to obtain an ethanol extract, and place it to cool to room temperature; Filtration i...

Embodiment 2

[0051] Preparation of Rape Pollen Fatty Acid Extract:

[0052] Step 1: Weigh 500 g of rape pollen, add 8 times the weight of water to the rape pollen, and stir at room temperature for 4 hours to obtain a pollen mixture; the pollen mixture is centrifuged, the supernatant is removed, and the precipitate is dried under reduced pressure to obtain a pollen solid.

[0053] Step 2, put the pollen solid obtained in step 1 into supercritical CO 2 Extraction is carried out in an extraction device, the extraction temperature is 50°C, and the extraction pressure is 35Mpa; separation kettle I: pressure 8MPa, temperature 50°C; separation kettle II: pressure 8MPa, temperature 50°C; extraction time 3h to obtain rape pollen supercritical extract .

[0054] Step 3, adding 50 times the weight of 70% (v / v) ethanol to the rape pollen supercritical extract obtained in step 2, and extracting at 50° C. for 2 hours with airtight stirring to obtain an ethanol extract, which was placed and cooled to ro...

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Abstract

The invention discloses a fatty acid extract of rape pollen as well as a preparation method and an application of the fatty acid extract. The preparation method of the fatty acid extract of the rape pollen comprises steps as follows: step one, the rape pollen is extracted with water, solid pollen matters obtained after water extraction are retained; step two, the solid pollen matters obtained in the step one are extracted in a supercritical CO2 extraction device, and a supercritical extract of the rape pollen is obtained; step three, the supercritical extract of the rape pollen is extracted with an ethanol solution, and an ethanol extract of the rape pollen is obtained; the ethanol extract of the rape pollen is filtered and concentrated, and the fatty acid extract of the rape pollen is obtained. The fatty acid extract of the rape pollen and enriched effective substances of the rape pollen are mixed in the weight ratio being (1:1)-(12:1), and medicine composition is prepared. The fatty acid extract of the rape pollen or the medicine composition can be used for treating benign prostatic hyperplasia or chronic nonbacterial prostatitis.

Description

technical field [0001] The invention belongs to the technical field of extracting medicinal components in plants, in particular to a method for extracting rape pollen fatty acid extract from rape pollen, and the rape pollen fatty acid extract can be used as a raw material for treating benign prostatic hyperplasia or chronic non-bacterial prostatitis medicine. Background technique [0002] Rape (Brassica campestris L.) is a Brassica plant of the Brassicaceae family. Rapeseed pollen is the pollen grain of rapeseed, which has a variety of nutrients, in addition to sugar, protein, amino acids, minerals and vitamins and other nutrients, it also contains flavonoids, phytosterols, fatty acids and their derivatives. There have been many reports on the total flavonoids in rapeseed, but the research on the effective parts of fatty acid compounds has not been involved. [0003] Prostatic hyperplasia (BPH) is one of the common diseases in middle-aged and elderly men, and its incidence...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P13/08
Inventor 萧伟李璐顾小霞原少伟张红杨义芳吴云丁岗王振中
Owner JIANGSU KANION PHARMA CO LTD
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