Application of cistanche phenylethanoid glycosides extract in preparing drugs for controlling hepatic fibrosis

A technology of phenylethanol glycosides and liver fibrosis, which is applied in the direction of drug combination, digestive system, and pharmaceutical formulations, to achieve the effects of inhibiting synthesis, reducing hydroxyproline content, and promoting degradation

Inactive Publication Date: 2016-03-09
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through literature search, there is no report about the use of Cistanche cistanche

Method used

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  • Application of cistanche phenylethanoid glycosides extract in preparing drugs for controlling hepatic fibrosis
  • Application of cistanche phenylethanoid glycosides extract in preparing drugs for controlling hepatic fibrosis
  • Application of cistanche phenylethanoid glycosides extract in preparing drugs for controlling hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Application of Cistanche cistanche phenylethanol glycosides extract as a drug for preventing and treating liver fibrosis.

Embodiment 2

[0018] Embodiment 2: The difference from the above examples is that the phenylethanol glycoside extract is obtained according to the following steps: the first step is to obtain the crushed Cistanche after the dried plants of the genus Cistanche are crushed, and the crushed Cistanche is obtained by volume fraction 70% to 95% ethanol aqueous solution is used for reflux extraction, the number of reflux extraction is 2 to 3 times, and the time of each reflux extraction is 2 hours to 3 hours, and the extracts of each reflux extraction are combined to obtain the total Extraction solution, wherein, every kilogram of Cistanche cistanche crushed product is refluxed with 0.8 liters to 0.9 liters of ethanol aqueous solution with a volume fraction of 70% to 95%; in the second step, the total extract solution is purified by AB-8 resin to obtain Cistanche deserticola phenylethanol Glycoside extract. AB-8 resin is a commercially available AB-8 resin.

Embodiment 3

[0019] Embodiment 3: The difference from the foregoing examples is that the plant of the genus Cistanche is Herba Cistanche or Herba Salina or Herba Cistanche.

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Abstract

The invention relates to the technical field of application of a cistanche phenylethanoid glycosides extract, and discloses the application of a cistanche phenylethanoid glycosides extract in preparing drugs for controlling hepatic fibrosis for the first time. The anti-hepatic fibrosis effect of the cistanche phenylethanoid glycosides extract is remarkable, activation and proliferation of hepatic stellate cells can be restrained, collagen synthesis can be reduced, collagen degradation can be promoted, the content of collagen in hepatic fibrosis tissue and the content of hydroxyproline in hepatic tissue can be reduced, and then synthesis of the extracellular matrix is restrained, the anti-hepatic fibrosis function is realized and a new direction is provided for controlling hepatic fibrosis diseases.

Description

technical field [0001] The invention relates to the technical field of application of the phenylethanoid glycoside extract of Cistanche deserticola, and relates to the application of the phenylethanol glycoside extract of Cistanche deserticola as a medicine for preventing and treating liver fibrosis. Background technique [0002] Hepatic fibrosis (Hepatic fibrosis, HF) is a damage and repair process after repeated or chronic liver injury, mainly related to chronic inflammation and chemical factors that cause chronic liver damage, and has become a disease with high morbidity and mortality. Most of the various liver diseases develop into late liver cirrhosis through liver fibrosis, which is the main cause of death from liver diseases. The current research has made it clear that liver fibrosis is a dynamic process of unbalanced synthesis and degradation of extracellular matrix (ECM) ; Liver fibrosis and early cirrhosis are completely reversible. [0003] Traditional Chinese me...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61P1/16
Inventor 刘涛由淑萍赵军马龙木克热木·吐地买提张石蕾
Owner XINJIANG MEDICAL UNIV
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