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Heparin sodium crude product refining optimization technology

A technology for heparin sodium and crude products, applied in the biological field, can solve problems such as difficulty in obtaining high-quality heparin sodium products, unsuitable reaction conditions, and structural damage of heparin sodium

Inactive Publication Date: 2016-03-16
QINGDAO JIULONG BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the difficulty in controlling the amount of oxidant added and the reaction conditions in the prior art, excessive oxidant is often added, and the reaction conditions are not suitable, causing damage to the structure of heparin sodium, resulting in low yield and low activity, and it is difficult to obtain higher purity. Boutique Heparin Sodium Products

Method used

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Examples

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Embodiment Construction

[0004] The implementation of the present invention will be illustrated by specific specific examples below, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. An optimization process for refining crude heparin sodium, through crushing and screening, dissolving, enzymatic hydrolysis, filtration, oxidation and precipitation, drying and dehydration, the process for refining and optimizing crude heparin sodium is completed, and the specific steps are as follows: (1) Crushing and screening: the crude heparin sodium is first Grinding, then sieving, and crushing the larger particles again; (2) Dissolving: Put the pretreated crude heparin sodium into water, add sodium chloride solution, and stir with a mixer; (3) Enzymolysis : Add human trypsin to the dissolved mixed liquid, adjust the pH value to 8.2-9, and heat to 40-60°C, and the enzymolysis time is 4-8 hours; (4) Filtration: hea...

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Abstract

The present invention discloses a heparin sodium crude product refining optimization technology characterized in that: the heparin sodium crude product refining optimization technology can be completed after crushing screening, dissolution, enzymolysis, filtration, oxidation, precipitation, and drying for dehydration. By control of oxidizing agent hydrogen peroxide addition amount and number of oxidation times, heparin sodium can be refined by combination of methods of adsorption for impurity removal and enzymolysis, impurities in the heparin sodium can be more thoroughly removed, by adding of an enzyme activator, enzymolysis rate is greatly improved, the enzyme use amount is reduced, production cycle is shortened, production cost is reduced, and industrial production is facilitated.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to refining crude heparin sodium. Background technique [0002] Heparin sodium is a biochemical drug extracted from pig small intestine mucosa. It is an irreplaceable, life-saving drug of choice in surgery, and the market cannot be interrupted. Since it was used clinically in the 1940s, its scope of application has continued to expand, especially since the 1990s, the product is mainly used clinically to prevent thrombosis and treat cardiovascular diseases, blood diseases, uremia, etc. Western countries have begun to study the preventive effect of heparin sodium on cancer, and its new uses are increasing. The refining process of heparin sodium is mainly to remove protein and decolorize the crude heparin sodium to meet the requirements of the national pharmacopoeia. In the refining of heparin sodium in my country, potassium permanganate and hydrogen peroxide are often used as oxidizing ...

Claims

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Application Information

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IPC IPC(8): C08B37/10
CPCC08B37/0075
Inventor 刘冠男姜晨夏衬来
Owner QINGDAO JIULONG BIO PHARMA
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