Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of Yimaikang microcapsules

A technology of Yimaikang and microcapsules, which is applied in the field of preparation of Yimaikang microcapsules, can solve the problems of high manufacturing and medical costs, heavy economic burden on patients, and influence on drug efficacy, and achieve low production costs and smooth flow of microcapsules. Good performance, improve bioavailability

Active Publication Date: 2018-08-24
广西大海阳光药业有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are oral preparations and injections made from the above-mentioned various escutellaria, due to preparation technology and other reasons, most oral preparations have long dissolution time, low dissolution rate, poor absorption and low bioavailability after taking. Problems, especially the hard capsules made of it, are extremely susceptible to moisture and deterioration during production and storage, which affects the efficacy of the drug and directly affects the effect of treatment
In addition, patients with cardiovascular and cerebrovascular diseases need long-term treatment, long-term use of injections is very inconvenient, high manufacturing and medical costs, and heavy economic burden on patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 2000 parts of Erigeron breviscapus medicinal material, crush it into coarse powder, add 16000 parts of ethanol with a concentration of 75%, heat and reflux for extraction 3 times, each time for 1 hour, filter, and the filtrate is concentrated under reduced pressure at 65°C until it has no alcohol smell, and then filtered , the filtrate was concentrated into an extract, dried under reduced pressure at 90°C, and the water content was reduced to 6%, and the dry extract powder of Erigeron breviscapine was obtained.

Embodiment 2

[0029] Take 2,000 parts of Erigeron breviscapus medicinal material, crush it into coarse powder, add 14,000 parts of 70% ethanol, heat and reflux for extraction twice, each time for 1.5 hours, filter, and concentrate the filtrate under reduced pressure at 60°C until it has no alcohol smell, and filter , the filtrate was concentrated into an extract, dried under reduced pressure at 85°C, and the water content was reduced to 5%, to obtain dry extract powder of Erigeron breviscapine.

Embodiment 3

[0031] Take 2000 parts of Erigeron breviscapus medicinal material, crush it into coarse powder, add 12000 parts of ethanol with a concentration of 65%, heat and reflux for extraction twice, each time for 2 hours, filter, and the filtrate is concentrated under reduced pressure at 70°C until it has no alcohol smell, and then filtered , the filtrate was concentrated into an extract, dried under reduced pressure at 80°C, and the water content was reduced to 5.5%, to obtain the dry extract powder of Erigeron breviscapine.

[0032] 2. Preparation of Yimaikang Microcapsules

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing a Yimaikang micro-capsule. The method comprises the following steps: putting gelatin into a compounding pot, adding water, heating at 70-80 DEG C to dissolve gelatin to obtain a gelatin solution, then adding erigeron breviscapus dry cream powder while stirring, and finally stirring with a homogenizer to dissolve erigeron breviscapus dry cream powder in the gelatin solution to prepare a water phase; putting liquid paraffin into the compounding pot, then adding span 80, heating to 70-80 DEG C, and uniformly mixing to prepare an oil phase; slowly adding the water phase into the oil phase to prepare a suspension; then adding isopropanol of which the volume is 6-8% of that of the suspension, performing still standing and filtering, and separating the solid phase from the liquid phase, wherein the solid phase is the micro-capsule. According to the method, the hygroscopicity of relevant preparations can be obviously reduced, and the stability of the finished product of the Yimaikang micro-capsule can be improved; the method is simple in process, low in production cost, low in energy consumption, and easy for industrialized production.

Description

technical field [0001] The invention relates to the preparation of a pharmaceutical preparation intermediate for treating cardiovascular and cerebrovascular diseases and peripheral neuropathy, especially a preparation method of Yimaikang microcapsules. Background technique [0002] Erigeron brevisca pus (Vant.) Hand.-Mazz. is the dry whole herb of Asteraceae Erigeron brevisca pus (Vant.) Hand.-Mazz. Modern pharmacological research shows that: (1) Erigeron breviscapus has significant anticoagulant effect, which can reduce platelet count and inhibit platelet aggregation, promote the activity of fibrinolytic system and coagulation function in vivo, so it has antithrombotic effect; Xin can relax blood vessels, reduce neuron damage caused by cerebral ischemia, thereby relaxing cerebral blood vessels and resisting cerebral ischemia; - The permeability of the brain barrier, resisting platelet aggregation caused by adenosine diphosphate and improving the phagocytic function of macr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/42A61K36/28A61P9/10A61P25/02
CPCA61K9/5057A61K36/28
Inventor 黄大权邓春霞唐新
Owner 广西大海阳光药业有限公司