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Traditional Chinese medicine preparation for treating pleurisy

A traditional Chinese medicine preparation and a technique for pleurisy, which is applied in the field of traditional Chinese medicine preparations for treating pleurisy, can solve the problems of great pain and poor curative effect of patients, and achieve the effects of high cure rate, stable drug efficacy and easy industrial transformation.

Inactive Publication Date: 2016-03-23
QINGDAO HUAZHICAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine mainly uses antibiotics and hormones for treatment, and patients with poor curative effect suffer a lot

Method used

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  • Traditional Chinese medicine preparation for treating pleurisy
  • Traditional Chinese medicine preparation for treating pleurisy
  • Traditional Chinese medicine preparation for treating pleurisy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] In order to further verify the feasibility of the present invention and provide samples for follow-up tests, the inventor selected several groups of representative raw material ratios (as shown in Table 1) for the production of pills. The scope of protection of the present invention includes but is not limited to this Example.

[0055] Table 1 Raw material ratio of each group

[0056]

[0057] (1), weigh Bupleurum, Prunella vulgaris, Lily, Tinglizi, Ligustrum lucidum, S. sinensis, Angelica, Trichosanthes, Digupi, Scutellaria baicalensis, Citrus aurantium, Rhubarb, Glauber’s salt, Guizhi, dandelion, trichosanthes, frankincense, peach kernel, salvia miltiorrhiza, licorice;

[0058] (2) Grind Tinglizi, Fructus Aurantii and Licorice respectively, fry and grind until fine, pass through a 90-mesh sieve, mix to obtain fine powder a, set aside;

[0059] (3) Dry and grind trichosanthes and frankincense separately, pass through a 90-mesh sieve, and mix to obtain a fine powde...

Embodiment 2

[0065] Toxicity test

[0066] Acute and chronic toxicity tests were carried out with the pellets numbered A-C produced in Example 1 of the present invention.

[0067] 1. Acute toxicity test

[0068] The Chinese medicine preparation of the present invention can't measure the half lethal dose (LD) because of being limited by the concentration of the medicinal liquid and the volume of intragastric administration. 50 ), with the maximum liquid concentration (1.86g crude drug / ml) and the maximum administration volume of the animal (0.4ml / 10g body weight) orally administered 3 times a day (interval 4 hours), the maximum dosage in a day is 223.2g Crude drug / kg. It is 519.1 times of adult clinical dosage (0.43g / kg / d). After continuous observation for 14 days, no obvious toxic reaction occurred in the animals at this dose. After the administration, the body weight of all the animals increased gradually, and none of the animals died within 14 days, and no toxic reaction or target or...

Embodiment 3

[0074] Pharmacodynamic experiment of Chinese medicine preparation of the present invention

[0075] 1. Inhibition of PGE2 synthesis in rat inflammatory tissue

[0076] Get 80 SD rats of 215 ± 11g, regardless of male or female, be randomly divided into 8 groups, two groups of Chinese medicine pills of B and C prepared in Example 1 of the present invention have high, middle and low doses, metronidazole control group and blank control group , 10 rats in each group, the dosage, the high, middle and low levels of this product (40, 20, and 10 times the clinical dosage) were 17.2g / kg, 8.6g / kg, 4.3g / kg, respectively, and the metronidazole group was 4.0g / kg. kg (10 times the clinical dose), administered for three consecutive days, 1 hour after the last dose, subcutaneously injected 0.1ml of 1% carrageenan into the right hind foot, and 4 hours after the inflammation was induced, the rats were sacrificed and placed on the ankle joint. Cut off the swollen foot at 0.5cm, peel off, cut int...

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Abstract

The invention relates to a traditional Chinese medicine preparation for treating pleurisy and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine preparation is mainly prepared from radix bupleuri, prunella vulgaris, lilies, semen lepidii, fructus ligustri lucidi, white mustard seeds, radix angelica sinensis, snake gourd fruits, cortex lycii radicis, scutellaria baicalensis, fructus surantii, rheum rhabarbarum, mirabilite, cassia twigs, dandelions, radix trichosanthis, frankincense, peach kernels, salvia miltiorrhiza and licorice. The traditional Chinese medicine preparation has the remarkable technological advantages that the preparation is good in treatment effect and high in cure rate, pleurisy will not relapse after healing, and the preparation has no toxic and side effects when the preparation is used for treating pleurisy. Besides, the preparation is convenient to carry, stable in medicine effect and good in universal adaptability, the technology of the preparation is easy and convenient to execute, raw material medicine is easy to obtain, industrial conversion is easy, and higher social value can be created.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating pleurisy, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Pleurisy refers to pleurisy caused by stimulation of pleura by pathogenic factors (usually viruses or bacteria), also known as "pleurisy". There may be fluid accumulation in the chest cavity (exudative pleurisy) or no fluid accumulation (dry pleurisy). After the inflammation is controlled, the pleura may return to normal, or two layers of pleura may adhere to each other. The main clinical manifestations are chest pain, cough, chest tightness, shortness of breath, and even dyspnea. [0003] Western medicine believes that pleurisy can be caused by the following diseases: pneumonia, pulmonary infarction caused by pulmonary embolism, cancer, tuberculosis, rheumatoid arthritis, systemic lupus erythematosus, parasitic infection (such as amebiasis), pancreatitis, injury ( ...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61P11/00A61P29/00A61K33/04
CPCA61K33/04A61K36/232A61K36/233A61K36/288A61K36/31A61K36/324A61K36/428A61K36/484A61K36/536A61K36/537A61K36/539A61K36/54A61K36/638A61K36/708A61K36/736A61K36/752A61K36/815A61K36/8967A61K2300/00
Inventor 李洪兴
Owner QINGDAO HUAZHICAO PHARMA CO LTD
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