Silicon hydrogel material having high oxygen permeability, corneal contact lens, and preparation method thereof

A corneal contact lens, silicon hydrogel technology, applied in glasses/goggles, instruments, optics, etc., can solve problems such as being unsuitable for industrialized large-scale production, complex monomer synthesis, low elastic modulus, etc., and achieve good penetration. Oxygen and hydrophilicity, simple process, good elongation effect

Active Publication Date: 2016-03-23
JIANGSU HORIEN CONTACT LENS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the synthesis of monomers is relatively complicated, requiring step-by-step catalytic synthesis of catalysts and ultraviolet light, which is not suitable for large-scale industrial production.
[0011] Therefore, there are still problems in contact lenses such as high oxygen permeability, strong hydrophilicity, low elastic modulus, high transparency, high biocompatibility, simple process, and easy mass production.

Method used

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  • Silicon hydrogel material having high oxygen permeability, corneal contact lens, and preparation method thereof
  • Silicon hydrogel material having high oxygen permeability, corneal contact lens, and preparation method thereof
  • Silicon hydrogel material having high oxygen permeability, corneal contact lens, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A silicone hydrogel material with high oxygen permeability provided in this embodiment is formed by polymerization reaction of the following components in parts by mass:

[0045]

[0046] Initiators and crosslinkers;

[0047] Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 3% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.1-3%.

[0048] In above-mentioned embodiment 1, macromolecular silicon monomer has the molecular formula of following structure:

[0049]

[0050] or

[0051]

[0052] Wherein, the structural formula of X is as follows:

[0053]

[0054] Wherein, the value range of a is an integer ranging from 1 to 14, the value range of b is an integer ranging from 1 to 6, and the value range of c is an integer ranging ...

example 1

[0066] Take 13g diol (the structural formula is shown in the following formula W1), 20mL chloroform, 0.1g catalyst dibutyltin dilaurate, 3.1g isocyanoethyl methacrylate (IEM), mix well, and heat to reflux at 50°C for 10h. After the reaction, wash with petroleum ether, let stand to separate layers, take the lower layer liquid and distill under reduced pressure to obtain transparent amphiphilic macromolecular silicon monomer, which is marked as M1-W1.

[0067]

example 2

[0069] Take 13g of diol (the structural formula is as shown in the above formula W1), 30mL of tetrahydrofuran, 2.8g of glycidyl methacrylate (GMA), 0.5g of trifluoromethanesulfonic acid, magnetic stirring, reflux at 60°C for 30min, and depressurize after the reaction Distillation to obtain a transparent amphiphilic macromolecular silicon monomer, denoted as M2-W1.

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Abstract

The invention discloses a silicon hydrogel material having high oxygen permeability. The silicon hydrogel material is prepared, through a polymerization reaction, from following components including, by mass, 10-40 parts of an amphipathic macro-molecular silicon monomer, 10-30 parts of a small-molecular silicon monomer, 40-80 parts of a hydrophobic monomer, 0-30 parts of an organic solvent, and an initiator and a crosslinking agent. The silicon hydrogel material and a corneal contact lens have the high oxygen permeability, are low in cost and are easy to prepare.

Description

technical field [0001] The invention relates to a silicon hydrogel material, in particular to a silicon hydrogel material with high oxygen permeability, a corneal contact lens and a preparation method thereof. Background technique [0002] Since the 1950s, contact lenses have gradually appeared in the market to correct vision, protect the eyeball or increase the beauty of the eye. With the development of science and technology, contact lenses have also realized the development from hard materials to soft materials that are more suitable for human eyes. [0003] The earliest lens material appeared was the rigid contact lens. Due to its shortcomings such as hard material, poor wettability, and low oxygen permeability, it is easy to cause eye discomfort when worn, and it is no longer the main commercially available lens. Subsequently, soft contact lenses were gradually developed, which can be divided into hydrophilic materials and non-hydrophilic materials. Hydrophilic conta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/12C08F220/28C08F226/02C08F226/10C08F220/06C08F230/08G02C7/04
CPCC08F283/124G02C7/049C08F220/281
Inventor 张雪勤陶慧文林保平陈平韩雪莲
Owner JIANGSU HORIEN CONTACT LENS
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