Meisuoshuli dispersible tablet and preparation method thereof

A technology of mesosulide and dispersible tablets, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, active ingredients of amides, etc. It can solve the problems of inconvenient taking three times, affecting the overall curative effect, and prone to missed doses, etc. Achieve high oral bioavailability, good medication compliance, and improve dissolution rate

Inactive Publication Date: 2016-03-30
WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Mesosulide is a poorly soluble drug that can be made into ordinary tablets, but it is not convenient to take it three times a day, and it is prone to missed doses, which affects the overall efficacy
[0004] At present, research on mesosulide preparations still needs to be strengthened

Method used

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  • Meisuoshuli dispersible tablet and preparation method thereof
  • Meisuoshuli dispersible tablet and preparation method thereof
  • Meisuoshuli dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] prescription:

[0064] 25 parts by weight of mesosulide, 5 parts by weight of aspartame, 60 parts by weight of microcrystalline cellulose, 5 parts by weight of hydroxypropylmethylcellulose, 2 parts by weight of sodium carboxymethyl starch, 0.5 parts by weight of magnesium stearate

[0065] Preparation:

[0066] (1) The above prescription amount of mesosulide was dissolved in 25ml of acetone to obtain liquid A, and the prescription amount of microcrystalline cellulose and hydroxypropylmethylcellulose were dissolved in 100ml of purified water to obtain liquid B;

[0067] (2) Slowly add liquid A to liquid B while stirring to obtain a mixed mesosulide suspension;

[0068] (3) Homogenize the suspension solution with a homogenizer, then spray dry, and collect the powder;

[0069] (4) the magnesium stearate, aspartame, carboxymethyl starch sodium of powder and prescription quantity are mixed uniformly, get mixed powder, get the sample of mixed powder, and carry out assay, af...

Embodiment 2

[0074] prescription:

[0075] 25 parts by weight of mesosulide, 10 parts by weight of sucrose, 30 parts by weight of lactose, 50 parts by weight of microcrystalline cellulose, 5 parts by weight of povidone, 3 parts by weight of crospovidone, and 0.5 parts by weight of micronized silica gel

[0076] Preparation:

[0077] (1) Dissolve the above prescription amount of mesosulide in 25ml of ethanol to obtain liquid A, and dissolve the prescribed amount of lactose, microcrystalline cellulose and povidone in 100ml of purified water to obtain liquid B;

[0078] (2) Slowly add liquid A to liquid B while stirring to obtain a mixed mesosulide suspension;

[0079] (3) Homogenize the suspension solution with a homogenizer, then spray dry, and collect the powder;

[0080] (4) Mix the powder with the prescribed amount of micropowder silica gel, sucrose, and crospovidone evenly to obtain a mixed powder, take a sample of the mixed powder, and perform content determination, and perform table...

Embodiment 3

[0083] prescription:

[0084] 50 parts by weight of mesosulide, 10 parts by weight of aspartame, 100 parts by weight of microcrystalline cellulose, 10 parts by weight of hydroxypropylmethylcellulose, 5 parts by weight of sodium carboxymethyl starch, 1 part by weight of magnesium stearate

[0085] Preparation:

[0086] (1) Dissolve the above prescription amount of mesosulide in 50ml of ethanol to obtain liquid A, and dissolve the prescription amount of microcrystalline cellulose and hypromellose in 120ml of purified water to obtain liquid B;

[0087] (2) Slowly add liquid A to liquid B while stirring to obtain a mixed mesosulide suspension;

[0088] (3) Homogenize the suspension solution with a homogenizer, then spray dry, and collect the powder;

[0089] (4) the magnesium stearate, aspartame, carboxymethyl starch sodium of powder and prescription quantity are mixed uniformly, get mixed powder, get the sample of mixed powder, and carry out assay, after content is qualified, c...

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Abstract

The invention provides a Meisuoshuli dispersible tablet and a preparation method thereof. The Meisuoshuli dispersible tablet comprises Meisuoshuli and pharmaceutically acceptable auxiliary materials. The Meisuoshuli dispersible tablet has the advantages of stable quality, required disintegration, rapid dissolution, uniform content, high bioavailability and good medication compliance.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to mesosulide dispersible tablets and a preparation method thereof. Background technique [0002] Mesosulide is the world's first Class 1.1 chemical drug jointly developed by the Academy of Military Medical Sciences and Humanwell Pharmaceutical Group. Mesosulide is a non-steroidal anti-inflammatory drug (NSAID for short), and its main mechanism of action is to inhibit cyclooxygenation. Enzyme (COX-2) activity, thereby inhibiting the final production of prostacyclin (PGⅡ), prostaglandin (PGE1, PGE2) and thromboxane A2 (TXA2) from arachidonic acid, that is, reducing the production of prostaglandin, thromboxane and other inflammatory mediators Synthetic, so it has good antipyretic, analgesic, anti-inflammatory, swelling and other effects. [0003] Mesosulide is a poorly soluble drug that can be prepared into ordinary tablets, but it is inconvenient to take three times a d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/18A61K47/26A61K47/38A61K47/36A61K47/18A61K47/12
Inventor 许勇王学海李莉娥廖娟娟黄怡黄璐涂荣华杨仲文乐洋江曦朱垒余艳平刘荃王伟田华肖强范昭泽杨菁张毅
Owner WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA
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