Preparation method of RGD-M13 bacteriophage/oxidized regenerated cellulose composite hemostatic material
A RGD-M13, regenerated cellulose technology, applied in pharmaceutical formulations, pharmaceutical sciences, bandages, etc., can solve the problems of reduced mechanical strength and bioabsorbability of oxidized regenerated cellulose, small increase in hemostasis time, etc., to ensure biological Absorbable properties, improving hemostatic properties, and improving the effect of grafting rate
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specific Embodiment approach 1
[0022] Specific Embodiment 1: This embodiment is a preparation method of RGD-M13 bacteriophage / oxidized regenerated cellulose composite hemostatic material, which is completed according to the following steps:
[0023] 1. Activation of oxidized regenerated cellulose: immerse oxidized regenerated cellulose into 2-morpholineethanesulfonic acid with a molar concentration of 0.1mol / L, and then ultrasonically treat it for 10min~30min at an ultrasonic power of 160W~400W, then add 1-Ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, then react at room temperature and at a stirring speed of 200r / min~550r / min for 15min ~20min to obtain activated oxidized regenerated cellulose;
[0024] The mass fraction of carboxyl groups in the oxidized regenerated cellulose in step 1 is 16% to 24%; the oxidized regenerated cellulose exists in the form of short filaments, filaments or fabrics;
[0025] The volume ratio of the amount of carboxyl in the oxidized regenera...
specific Embodiment approach 2
[0037] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the mass fraction of carboxyl groups in the oxidized regenerated cellulose described in step 1 is 17.5%. Other steps are the same as in the first embodiment.
specific Embodiment approach 3
[0038] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that in step one, the oxidized regenerated cellulose is immersed in 2-morpholineethanesulfonic acid with a molar concentration of 0.1mol / L, and then Ultrasonic treatment at 400W for 15min, then add 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, then at room temperature and stirring speed React at 450 r / min for 15 minutes to obtain activated oxidized regenerated cellulose. Other steps are the same as those in Embodiment 1 or 2.
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