Method for preparing fish scale gelatin plasma substitute injection

Abstract

The invention relates to a method for preparing a fish scale gelatin plasma substitute injection. The method for preparing the fish scale gelatin plasma substitute injection includes the steps that fish scale gelatin serves as a raw material, and the plasma substitute injection is obtained through the production processes of gelatin degradation, cross-linking modification, electrolyte adding, adsorption, filtering, filling, sterilization, lamp inspection, packaging and the like. The method has the advantages that the plasma substitute injection is prepared from the fish scale gelatin, the low cost of the raw material is guaranteed, potential safety risks, caused when a gelatin raw material from animals such as pigs and cows possibly carries epidemic diseases such as a foot-and-mouth disease and a mad cow disease, of the human body are avoided, and a fish scale gelatin plasma substitute has higher biosecurity; succinic anhydride is used as a cross-linking agent, and therefore the toxic and side effects on the human body are avoided; a proper quantity of electrolytes are added, and therefore it is guaranteed that electrolyte disturbance can not be caused when a large quantity of fish scale gelatin plasma substitutes are injected; as a porous titanium bar and a microporous filtering film are combined to carry out classified filtering, the filtering speed is greatly increased, and the method is better suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and relates to a method for preparing fish scale gelatin instead of plasma injection using fish scale gelatin as a raw material. Background technique [0002] The annual medical blood consumption in our country is as high as 1300 tons. In recent years, the blood consumption is still increasing at a rate of 7% to 10% per year. The rapid increase in clinical blood consumption has caused the shortage of blood to reach a crisis level. Clinically, 90% of hepatitis C is transmitted by blood transfusion. Among the key infectious diseases, the case of transfusion infection has been ranked first for many years, and accidents of human immunodeficiency virus infection due to blood transfusion occur frequently. Blood shortage, difficulty in storage and transportation, high price and many other reasons make blood transfusion more and more cautious in clinic, and reduce the chance of blood transfusion as much...

AI Technical Summary

Problems solved by technology

[0009] At present, the raw materials for the preparation of gelatin-substituted plasma mainly come from the skin and bones of pigs, cattle and other animals. Because they may carry epidemic diseases such as foot-and-mouth disease and mad cow disease, there are safety risks such as pathogenicity and allergies; Plasma substitutes prepared from fur, sea dog skin, etc. have the problem of high raw material costs

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