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Method for preparing titanium metal with antimicrobial and anticancer performance

A titanium metal and performance technology, applied in the field of preparing titanium metal with antibacterial and anticancer properties, can solve problems such as poor water solubility, patient danger, environmental pollution, etc., and achieve the effects of molecular stability, antibacterial effect, antitumor, and good biological activity.

Active Publication Date: 2016-04-06
陕西康美诺医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, some ruthenium complexes have poor water solubility. If they are directly introduced into the surface of titanium metal, more organic solvents need to be used, which will pollute the environment, and there may be solvent residues on the titanium metal, which will cause danger to patients.

Method used

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  • Method for preparing titanium metal with antimicrobial and anticancer performance
  • Method for preparing titanium metal with antimicrobial and anticancer performance
  • Method for preparing titanium metal with antimicrobial and anticancer performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This scheme prepares the method for the titanium metal with antibacterial and anticancer performance, comprises the following steps:

[0030] 1) Dissolve 65 parts by weight of ruthenium trichloride hydrate and 480 parts by weight of gamma-terpinene in 1455 parts by weight of dehydrated alcohol, heat and reflux and stir for 6 hours, and leave to separate out to obtain a compound of formula (1), namely Dichloro-di-methylcumene diruthenium dichloride;

[0031]

[0032] 2) Dissolve 4 parts by weight of m-carboxybenzaldehyde and 10 parts by weight of toluene, then add 10 parts by weight of 1-(9-anthracenyl)ethanol and 1 part by weight of sulfuric acid with a concentration of 98%, and then control 110° C. to stir and reflux for 2 hours, Then the filtrate is spin-dried, 5 parts by weight of ethyl acetate is added for extraction, the process of ethyl acetate extraction is repeated 4 times, the ethyl acetate layer solution is combined, 10 parts by weight of anhydrous potassiu...

Embodiment 2

[0042] This scheme prepares the method for the titanium metal with antibacterial and anticancer performance, comprises the following steps:

[0043] 1) Dissolve 65 parts by weight of ruthenium trichloride hydrate and 470 parts by weight of gamma-terpinene in 1450 parts by weight of dehydrated alcohol, heat and reflux and stir for 5 hours, and leave to separate out to obtain a compound of formula (1), namely Dichloro-di-methylcumene diruthenium dichloride;

[0044]

[0045] 2) Dissolve 3 parts by weight of m-carboxybenzaldehyde and 5 parts by weight of toluene, then add 8 parts by weight of 1-(9-anthracenyl)ethanol and 0.5 parts by weight of sulfuric acid with a concentration of 98%, and then control 100°C to stir and reflux for 1.5h , then the filtrate is spin-dried, adding 3 parts by weight of ethyl acetate for extraction, repeating the extraction process of ethyl acetate 3 times, combining the ethyl acetate layer solution, adding 8 parts by weight of anhydrous potassium c...

Embodiment 3

[0055] This scheme prepares the method for the titanium metal with antibacterial and anticancer performance, comprises the following steps:

[0056] 1) 70 parts by weight of ruthenium trichloride hydrate and 480 parts by weight of gamma-terpinene were dissolved in 1500 parts by weight of dehydrated alcohol, heated to reflux and stirred for 7 hours, and left to separate out to obtain a compound of formula (1), namely Dichloro-di-methylcumene diruthenium dichloride;

[0057]

[0058] 2) Dissolve 5 parts by weight of m-carboxybenzaldehyde and 15 parts by weight of toluene, then add 12 parts by weight of 1-(9-anthracenyl)ethanol and 1.5 parts by weight of sulfuric acid with a concentration of 98%, and then control 120° C. to stir and reflux for 2.5 hours , then the filtrate is spin-dried, adding 10 parts by weight of ethyl acetate for extraction, repeating the extraction process of ethyl acetate for 5 times, combining the ethyl acetate layer solution, adding 15 parts by weight ...

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Abstract

The invention discloses a method for preparing titanium metal with the antimicrobial and anticancer performance. The method includes the following steps that 1, a ruthenium complex is prepared; 2, by weight, 0.1-0.6 part of cyclodextrin is dissolved in 3.5-20 parts of water and evenly stirred, and then 0.5-1.5 parts of titanium metal is added and soaked for 20-60 min; 3, by weight, 0.2-1.2 parts of the ruthenium complex is added, and then the mixture is treated for 30-60 min with 15-30 kHz ultrasonic waves; 4, the titanium metal is taken out and dried. According to the method, due to the effects of the cyclodextrin and the ruthenium complex on the titanium metal, the titanium metal has the good antimicrobial and anticancer performance, the surface of the titanium metal is beneficial to growth of osteocytes, the incidence rate of complications caused by the titanium metal in an osseointegration operation is reduced, and a safer and more reliable material is provided for the osseointegration operation.

Description

technical field [0001] The invention relates to the technical field of materials for osseointegration surgery, in particular to a method for preparing titanium metal with antibacterial and anticancer properties. Background technique [0002] β-cyclodextrin is a class of macrocyclic compounds formed by connecting 7 D-glucopyranose units end-to-end through α-1,4 glycosidic bonds. Inside the molecule is a "V"-shaped hydrophobic cavity, showing a unique molecular recognition ability. As a commonly used material in osseointegration surgery, titanium metal is widely used clinically. However, a serious problem is the associated bacterial infection problem, which leads to the failure of a large number of transplant operations. At present, there have been some reports on improving the antibacterial ability of titanium metal, such as using antibacterial molecules such as antibiotics to improve the antibacterial effect of titanium metal. Recently, researchers have been working to im...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/54C23C22/68
CPCA61L27/06A61L27/54A61L2300/224A61L2300/404A61L2300/416A61L2300/802A61L2400/18A61L2430/02A61L2430/12C23C22/68
Inventor 李培源苏炜霍丽妮陈睿
Owner 陕西康美诺医疗科技有限公司
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