Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of composition of benzenebutanoic acid and triazole antifungal drug and antifungal product

An antifungal drug, combined application technology, applied in the field of medicine, can solve problems such as increasing drug resistance rate, and achieve the effect of enhancing antibacterial activity, strong effect, and expanding the scope of application

Active Publication Date: 2016-04-20
QIANFOSHAN HOSPITAL OF SHANDONG
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide an application of phenylbutyric acid combined with triazole antifungal drugs and its products in order to overcome the current problem of fungal infection and the increase in the resistance rate of triazole antifungal drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of composition of benzenebutanoic acid and triazole antifungal drug and antifungal product
  • Application of composition of benzenebutanoic acid and triazole antifungal drug and antifungal product
  • Application of composition of benzenebutanoic acid and triazole antifungal drug and antifungal product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0034] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0035] Embodiment Phenylbutyric acid and triazole antifungal drugs combined antifungal action determination

[0036] 1. Materials

[0037] 1.1 Drugs and reagents

[0038] Fluconazole (FLC), Meilun Biological Co., Ltd.;

[0039] Voriconazole (VRC), Meilun Biological Co., Ltd.;

[0040] Itraconazole (ITC), Meilun Biological Co., Ltd.;

[0041] Phenylbutyric acid (PBA): Shaoyuan Chemical Technology (Shanghai) Co., Ltd.;

[0042] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0043] TTC-Sapauer agar, Hangzhou Tianhe Microbiological Reagent Co., Ltd.;

[0044] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0045] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0046] Glucose, Sinopharm Chemical Reagent Co., Ltd.;

[0047] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[00...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the application of the composition of benzenebutanoic acid and a triazole antifungal drug and an antifungal product. Static and dynamic combined antifungal activity, on drug-resisting candida albicans (CA), of the composition of the triazole antifungal drug and benzenebutanoic acid is researched. When PBA is combined with FLC, ITC and VRC, the antimicrobial activity of the triazole antifungal drug on drug-resisting CA can be improved, a synergic antifungal effect can be realized, the drug resistance of drug-resisting CA on the triazole antifungal drug can be reversed, and a research direction is provided for development of new drugs and new application of old drugs. For CA (MIC>=512 mug / ml) resistant to FLC, ITC and VRC, minimal inhibitory concentration can be reduced remarkably through drug combination, over 80% fungi can be killed through combination of PBA of 32 mug / ml and FLC of 1 mug / ml, combination of PBA of 32 mug / ml and ITC of 0.125 mug / ml, and combination of PBA of 16 mug / ml and VRC of 0.25 mug / ml, and the effect is better as concentration becomes higher.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of phenylbutyric acid combined with triazole antifungal drugs and the products thereof. Background technique [0002] With the increase of patients with acquired immunodeficiency syndrome and the wide application of broad-spectrum antibacterial drugs, the development of medical technologies such as organ transplantation technology and catheter technology, the morbidity and mortality of invasive fungal infections are also increasing year by year. The morbidity and fatality rate of bacteria reached 40%, occupying the fourth place in the hospital acquired bloodstream infection. Among them, Candida albicans (Candida albicans, CA) is a common isolate in clinical fungal infections, usually treated with azole antifungal drugs fluconazole (FLC), voriconazole (Voriconazole, VRC), itraconazole (Itraconazole, ITC) treatment. As a safe, effective and cheap azole antifungal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4196A61K31/496A61K31/506A61K31/192A61P31/10
CPCA61K31/192A61K31/4196A61K31/496A61K31/506A61K2300/00
Inventor 孙淑娟张柳平李涛时银萍赵霞
Owner QIANFOSHAN HOSPITAL OF SHANDONG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com