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Preparation method of resin used for blood purification to remove β2-microglobulin

A microglobulin and blood purification technology, applied in the field of biomedical engineering, can solve the problems of limited curative effect and limited removal of microglobulin, and achieve the effects of high adsorption performance, large-scale production and preparation, and simple production process.

Active Publication Date: 2018-07-17
重庆希尔康血液净化器材研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More is to remove the toxic substances in the body of uremia patients through the broad-spectrum resin / activated carbon perfusion device, and its effect on the β in the body of uremia patients 2 - The removal of microglobulin is relatively limited, only through the rich specific surface area of ​​resin / activated carbon, suitable pore size and pore size for adsorption, the curative effect is limited

Method used

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  • Preparation method of resin used for blood purification to remove β2-microglobulin

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A kind for blood purification to remove beta 2 -Preparation method of microglobulin resin:

[0020] Step 1. First, prepare polystyrene-divinylbenzene microspheres;

[0021] Prepare the oil phase with p-styrene and divinylbenzene monomers at a mass ratio of 1:1, and add 0.5wt% initiator of the mixture of p-styrene and divinylbenzene and porogen less than 5wt%, adopt suspension polymerization Method: adding 3wt% stabilizer of a mixture of p-styrene and divinylbenzene, adding the oil phase to 80°C water and stirring for 12 hours to prepare polystyrene-divinylbenzene microspheres with ultra-high crosslinking degree. The polystyrene-divinylbenzene microspheres are cleaned with water or acetone and dried;

[0022] The initiator is benzoyl peroxide, the porogen is a mixture of any two of toluene, naphthalene, paraffin oil, benzene, and dodecane, and the stabilizer is gelatin.

[0023] Step 2. Next, chloromethylate polystyrene-divinylbenzene microspheres;

[0024] After the polystyrene...

Embodiment 2

[0029] A kind for blood purification to remove beta 2 -Preparation method of microglobulin resin:

[0030] Step 1. First, prepare polystyrene-divinylbenzene microspheres;

[0031] Prepare the oil phase with p-styrene and divinylbenzene monomers in a mass ratio of 1:2, and add 1wt% initiator of the mixture of p-styrene and divinylbenzene and 40wt% or less porogen at the same time, adopt the suspension polymerization method , Adding 10wt% stabilizer of a mixture of p-styrene and divinylbenzene, adding the oil phase to 80°C water, stirring and reacting for 24 hours to prepare polystyrene-divinylbenzene microspheres with ultra-high cross-linking degree. The styrene-divinylbenzene microspheres are cleaned with water or acetone and dried;

[0032] The initiator is benzoyl peroxide, the porogen is any one of toluene, naphthalene, paraffin oil, benzene, and dodecane, and the stabilizer is polyvinyl alcohol.

[0033] Step 2. Next, chloromethylate polystyrene-divinylbenzene microspheres;

[003...

Embodiment 3

[0039] A kind for blood purification to remove beta 2 -Preparation method of microglobulin resin:

[0040] Step 1. First, prepare polystyrene-divinylbenzene microspheres;

[0041] The p-styrene and divinylbenzene monomers are configured in the oil phase at a mass ratio of 1:1.5, and 0.8wt% of the initiator and 20wt% of the porogen of the mixture of p-styrene and divinylbenzene are added, and the suspension polymerization is adopted. Method, adding 5wt% stabilizer of a mixture of p-styrene and divinylbenzene, adding the oil phase to 80℃ water and stirring for 16 hours to prepare polystyrene-divinylbenzene microspheres with super high crosslinking degree, and then The polystyrene-divinylbenzene microspheres are cleaned with water or acetone and dried;

[0042] The initiator is benzoyl peroxide, the porogen is any one of toluene, naphthalene, paraffin oil, benzene, and dodecane, or a mixture of any two, and the stabilizer is polyvinyl alcohol Or gelatin.

[0043] Step 2. Next, chlorome...

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Abstract

The invention discloses a preparing method for resin for clearing away beta2-microglobulin in blood purification. The preparing method comprises the steps that firstly, polystyrene-divinylbenzene microspheres are prepared; secondly, the polystyrene-divinylbenzene microspheres and chloromethyl ether are subjected to a chloromethylation reaction, and chloromethylation microspheres are obtained; finally, long-chain hydrophobic groups are grafted to the chloromethylation microspheres. By means of the preparing method, styrene and divinybenzene serve as monomers, the polystyrene-divinylbenzene microspheres are obtained through suspension polymerization, and the size of pores in the microspheres is adjusted with a certain quantity of a pore-forming agent in the synthesizing process; then the microspheres serve as a carrier, alkyl is grafted through the chloromethylation reaction and an amination reaction, the microspheres with the adjustable specific surface area and the hydrophobic groups are obtained, and the resin is smooth in surface and high in strength and has very high adsorption performance on beta2-microglobulin in a uremia patient. The production technology is simple, the yield is high, and the product purity is high; meanwhile, raw materials are easy to obtain, and mass production and preparation can be achieved.

Description

Technical field [0001] The present invention relates to the field of biomedical engineering, in particular to a blood purification and removal β 2 -Preparation method of microglobulin resin. Background technique [0002] According to the statistics of the Ministry of Health of my country, there are 270,000 hemodialysis patients in China; 1.56 million patients with liver cirrhosis; more than 100,000 acute poisonings per year; systemic lupus erythematosus (910,000) and rheumatoid arthritis (13.26 million) )-Based autoimmune diseases; nearly 15 million; plus millions of patients with severe sepsis and hyperlipidemia, the number of potential patients who can undergo hemoperfusion therapy will reach more than 20 million. [0003] Hemoperfusion therapy is a kind of extracorporeal circulation that introduces the patient's blood into a perfusion device equipped with a solid adsorbent to remove certain exogenous or endogenous toxins and metabolites, and inject the purified blood back into th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/08C08F212/36C08F8/32C08F8/24B01J13/04B01J13/14
CPCB01J13/043B01J13/14C08F8/32C08J9/28C08J2325/08C08F8/24C08F212/08C08F212/36
Inventor 罗章凯张婷毛金春张文
Owner 重庆希尔康血液净化器材研发有限公司
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