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Toothpaste containing lysozyme

A technology of lysozyme and toothpaste, applied in the field of oral hygiene, to achieve the effect of preventing dental plaque, simple preparation method and reasonable compatibility

Active Publication Date: 2016-05-04
ZHEJIANG AEGIS BIOLOGICAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] At present, the combination of lysozyme and chrysanthemum notoginseng for the prevention and treatment of dental diseases, especially the application of gingivitis and dental plaque has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, the extraction of flat lying chrysanthemum notoginseng

[0036] After passing the powder of the stem part of Chrysanthemum notoginseng through a 40-mesh sieve, decolorize and degrease with petroleum ether for 3 hours, dry to constant weight, and then use 30 times the weight of 90% ethanol to heat and reflux at 80°C for 3 times, 2 hours each time, The extracts were combined, concentrated and dried.

Embodiment 2

[0037] Example 2, Preparation of Toothpaste Containing Lysozyme / Pianwo Junotoginseng Extract

[0038] Get 5 parts by weight of the chrysanthemum notoginseng extract made by embodiment 1, the silicon dioxide of 50 parts by weight, the sorbitol of 20 parts by weight, the carrageenan of 1 part by weight, the sodium saccharin of 0.2 parts by weight and the balance mixed with water to make 100 parts by weight of the toothpaste A1 containing the extract of Ju Notoginseng.

[0039] Get 5 parts by weight of lysozyme, 50 parts by weight of silicon dioxide, 20 parts by weight of sorbitol, 1 part by weight of carrageenan, 0.2 parts by weight of sodium saccharin and the rest of the water to make 100 parts by weight of Lysozyme Toothpaste A2.

[0040] Get the lysozyme of 4.167 parts by weight, 0.833 parts by weight of the flat-folding chrysanthemum notoginseng extract made by embodiment 1, the silicon dioxide of 50 parts by weight, the sorbitol of 20 parts by weight, the carrageenan of 1 ...

Embodiment 3

[0044] Example 3, Application of Toothpaste Containing Lysozyme / Pianju Notoginseng Extract in the Prevention and Treatment of Gingivitis and Dental Plaque

[0045] 3.1 Research object

[0046] Double-blind, stratified, parallel clinical study on healthy adult male and female volunteers. First of all, the researcher clearly explained the purpose of the experiment, the details of the study, and the responsibilities of participating in the study to the subjects. After the volunteers who are willing to participate fill out the voluntary form, the researchers will check it, and judge and screen the test population according to the inclusion and exclusion criteria. The initial screening process includes oral soft tissue and hard tissue inspection, gingivitis and plaque inspection to determine whether the subjects are selected. Finally, 210 subjects with modified Quigley-Hein plaque index ≥ 1.5 and Loe-Silness gingivitis index ≥ 1.0 were selected to participate in the study, and we...

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PUM

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Abstract

The invention relates to toothpaste containing lysozyme. The weight ratio of the active ingredients, namely lysozyme to a gynura procumbens extract in the toothpaste is (1:10)-(10:1). In comparison with common Chinese herbal medicine toothpaste, the lysozyme toothpaste provided by the invention is simple in preparation method and reasonable in compatibility, and the two active ingredients cal generate a synergistic action while giving play to respective effects, thereby significantly preventing oral cavity gingivitis and dental plaque. The lysozyme and gynura procumbens have natural sources, are safe and nontoxic, and have no side effects; and as the toothpaste does not contain a western medicine ingredient, the toothpaste has no drug tolerance.

Description

technical field [0001] The invention relates to the field of oral hygiene, in particular to a toothpaste. Background technique [0002] Medically, the soft tissue that surrounds and covers the teeth is called gingiva, and the acute and chronic inflammation that occurs in gingival tissue is called gingivitis. Manifested as gum bleeding, redness, swelling, pain, continue to develop invasion of hard tissue, resulting in periodontitis, including inflammation of gum tissue and systemic diseases in the gums. Dental plaque is a soft and unmineralized bacterial population wrapped in matrix that adheres to each other or adheres to the tooth surface, between teeth or the surface of the restoration. It is a bacterial biofilm that cannot be washed away by water or rinsed off. . When the amount of plaque is small, it is difficult to see with the naked eye, and usually it can be well displayed with a plaque indicator. [0003] Toothpaste is a preparation that assists in brushing teeth,...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/66A61Q11/00A61P1/02
CPCA61K8/66A61K8/97A61Q11/00
Inventor 潘宏涛卢亚萍
Owner ZHEJIANG AEGIS BIOLOGICAL SCI & TECH CO LTD
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