Medical application of catalpol and/or radix astragali seu hedysari extraction solution

Abstract

The invention discloses medical application of a catalpol and / or radix astragali seu hedysari extraction solution. Experiments show that the catalpol and / or radix astragali seu hedysari extraction solution can be used for preventing and treating or delaying motor neuron diseases and nerve injury. Results show that through injection of a catalpol injection solution, a radix astragali seu hedysari injection solution or a composition of the catalpol injection solution and the radix astragali seu hedysari injection solution, the occurrence time of amyotrophic lateralizing sclerosis can be delayed, the survival time can be prolonged, and the limb movement function can be obviously improved. The catalpol and / or radix astragali seu hedysari extraction solution has the effects of resisting shrinkage of spinal anterior horn motor neuron cells, maintaining or activating the growth state of the spinal anterior horn motor neuron cells, resisting neuronal apoptosis and protecting the neurons, has an effect of gaining weight, and also has a high curative effect on the traumatic type nerve injury; meanwhile, the effective components of the catalpol and / or radix astragali seu hedysari extraction solution can be extracted from the traditional Chinese medicines; the used medicines are low-cost and easily available; the catalpol and / or radix astragali seu hedysari extraction solution has a good market prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of catalpol and / or astragalus extract in preventing or delaying motor neuron disease and / or nerve damage. Background technique [0002] Motor neuron disease (MND) is a group of chronic progressive neurodegenerative diseases of unknown etiology that selectively invade spinal cord anterior horn cells, brainstem motor neurons, cortical pyramidal cells and pyramidal tracts. According to different clinical manifestations, motor neuron disease can generally be divided into the following four types: amyotrophic lateral sclerosis (ALS); progressive muscular atrophy (PMA); progressive bulbar palsy (PBP); primary lateral Hardened (PLS). Its harmfulness lies in the selective retrograde damage to motor neurons, which manifests as dysfunction and atrophy of the muscles controlled by neurons. If the throat and respiratory muscles are involved, life will end. In addition, m...

AI Technical Summary

Problems solved by technology

Due to the unclear etiology and mechanism, the current treatment is extremely difficult

The only clinically used drug for the treatment of ALS is Riruta (the common name is riluzole tablets, the English name is riluzolettablets, and its chemical name is: 2-amino-6-trifluoromethoxybenzothiazole), but the drug It cannot cure ALS, it can only delay the progression of the disease and prolong the survival time

The results of clinical trials prove that riluzole can only prolong the life span of patients by 2-3 months in the treatment of ALS; moreover, the drug is extremely expensive, and the families of most patients cannot afford it; moreover, the drug can cause liver and kidney damage. The perspective of supplementing neurotrophic factors to treat ALS is not supported by clinical results, and most of the remaining therapeutic interventions are in the stage of preclinical animal experiments

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