Medical application of catalpol and/or radix astragali seu hedysari extraction solution

A technology of astragalus extract and catalpol, applied in the field of medicine, can solve the problems of uncurable ALS, liver and kidney function damage, and difficult treatment, and achieve the effect of preventing or delaying motor neuron disease, delaying the onset time, and having a good market prospect

Active Publication Date: 2016-05-11
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the unclear etiology and mechanism, the current treatment is extremely difficult
The only clinically used drug for the treatment of ALS is Riruta (the common name is riluzole tablets, the English name is riluzolettablets, and its chemical name is: 2-amino-6-trifluoromethoxybenzothiazole), but the drug It cannot cure ALS, it can only delay the progression of the disease and prolong the survival time
The results of clinical trials prove that riluzole can only prolong the life span of patients by 2-3 months in the treatment of ALS; moreover, the drug is extremely expensive, and the families of most patients cannot afford it; moreover, the drug can cause liver and kidney damage. The perspective of supplementing neurotrophic factors to treat ALS is not supported by clinical results, and most of the remaining therapeutic interventions are in the stage of preclinical animal experiments

Method used

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  • Medical application of catalpol and/or radix astragali seu hedysari extraction solution
  • Medical application of catalpol and/or radix astragali seu hedysari extraction solution
  • Medical application of catalpol and/or radix astragali seu hedysari extraction solution

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The medicine for preventing or delaying motor neuron disease, nerve injury or / and degenerative disease and alleviating ALS, its raw material and preparation method are as follows:

[0024] Preparation method of Astragalus water extract: take Astragalus, add water equivalent to 8-10 times the weight of Astragalus and soak for 45 minutes, then heat and reflux extraction twice, each time for 1 hour, combine the extracts, and concentrate the extracts to 4 times the weight of Astragalus. times the concentrated solution to obtain the Radix Astragali water extract.

[0025] The preparation method of rehmannia glutinosa water extract: take the rehmannia glutinosa of the formula, add water equivalent to 8-10 times the weight of rehmannia glutinosa and soak for 45 minutes, then heat and reflux for extraction twice, each time for 1 hour, combine the extracts, and concentrate the extracts to the equivalent The concentrated solution of 4 times the weight of Rehmannia glutinosa is ob...

Embodiment 2

[0032] Pharmacodynamic investigation and evaluation of Astragalus root and Rehmannia glutinosa extracts in the treatment of amyotrophic lateral sclerosis (ALS), the specific methods are as follows: purchase 30 hSOD1-G93A transgenic mice and 6 wild type B6SJLF1 / J+ / + mice, The wild-type B6SJLF1 / J+ / + mice were used as the normal control NC group (n=6), and the hSOD1-G93A transgenic mice were randomly divided into 5 groups, which were named: ALS control group (n=6), positive drugs Luzole treatment group (Riluzole, n=6), Dihuang treatment group (catalpol 10mg / kg, n=6), Huangqi injection group (12g / kg, n=6), catalpol+Dihuang injection group (n =6). The specific grouping, dosage and method of administration are shown in Table 1:

[0033]Table 1. The specific grouping of experimental mice and the dosage and administration method

[0034]

[0035]

[0036] Then evaluate their water intake and food intake every 4 days, and evaluate their food intake and body weight changes. The...

Embodiment 3

[0062] Establishment of animal model of sciatic nerve injury: the animals were anesthetized by intraperitoneal injection of 3.5% chloral hydrate at a dose of 0.1ml / 10g, after binding, routine disinfection and skin preparation. Cut open the skin with a scalpel blade and make a median longitudinal incision at the posterior part of the right femur, and suddenly separate the muscles to expose the sciatic nerve at the lower border of the piriformis muscle. The hemostat clamps the sciatic nerve to the third tooth, four times in total, 15 seconds each time. After completion, the nerve was returned and the skin was sutured. In the sham operation group, only the sciatic nerve was exposed without clamping, and then the wound was sutured.

[0063] Animal grouping and administration: 60 mice successfully modeled were randomly divided into five groups: sham operation group, model group, rehmannia glutinosa alcohol extract group (60g / kg), astragalus alcohol extract group (60g / kg, concentra...

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Abstract

The invention discloses medical application of a catalpol and / or radix astragali seu hedysari extraction solution. Experiments show that the catalpol and / or radix astragali seu hedysari extraction solution can be used for preventing and treating or delaying motor neuron diseases and nerve injury. Results show that through injection of a catalpol injection solution, a radix astragali seu hedysari injection solution or a composition of the catalpol injection solution and the radix astragali seu hedysari injection solution, the occurrence time of amyotrophic lateralizing sclerosis can be delayed, the survival time can be prolonged, and the limb movement function can be obviously improved. The catalpol and / or radix astragali seu hedysari extraction solution has the effects of resisting shrinkage of spinal anterior horn motor neuron cells, maintaining or activating the growth state of the spinal anterior horn motor neuron cells, resisting neuronal apoptosis and protecting the neurons, has an effect of gaining weight, and also has a high curative effect on the traumatic type nerve injury; meanwhile, the effective components of the catalpol and / or radix astragali seu hedysari extraction solution can be extracted from the traditional Chinese medicines; the used medicines are low-cost and easily available; the catalpol and / or radix astragali seu hedysari extraction solution has a good market prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of catalpol and / or astragalus extract in preventing or delaying motor neuron disease and / or nerve damage. Background technique [0002] Motor neuron disease (MND) is a group of chronic progressive neurodegenerative diseases of unknown etiology that selectively invade spinal cord anterior horn cells, brainstem motor neurons, cortical pyramidal cells and pyramidal tracts. According to different clinical manifestations, motor neuron disease can generally be divided into the following four types: amyotrophic lateral sclerosis (ALS); progressive muscular atrophy (PMA); progressive bulbar palsy (PBP); primary lateral Hardened (PLS). Its harmfulness lies in the selective retrograde damage to motor neurons, which manifests as dysfunction and atrophy of the muscles controlled by neurons. If the throat and respiratory muscles are involved, life will end. In addition, m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/481A61P25/28A61K36/804
CPCA61K31/7048A61K36/481A61K36/804A61K2236/331A61K2236/333A61K2300/00
Inventor 祝慧凤王园俸珊万东邱邴勋
Owner SOUTHWEST UNIV
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