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Chitosan povidone-iodine solution and manufacturing technologythereof

A technology of povidone-iodine and chitosan is applied in the directions of chemicals used for biological control, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., and can solve the problems of limited bacteriostatic performance and the like, To achieve the effects of good product quality, good killing effect, and simple solution process

Active Publication Date: 2016-05-11
深圳市阳光百度生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Chitosan (chitosan) is the only positively charged branched polysaccharide in nature. It has antibacterial, antitumor, immune enhancement and other functions. It has good biocompatibility and is non-irritating and non-toxic. Due to 2- In the presence of NH2, chitosan has a certain antibacterial function, but the antibacterial performance is limited, and it is affected by conditions such as chitosan molecular weight and deacetylation degree

Method used

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  • Chitosan povidone-iodine solution and manufacturing technologythereof
  • Chitosan povidone-iodine solution and manufacturing technologythereof
  • Chitosan povidone-iodine solution and manufacturing technologythereof

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Embodiment 1

[0025] A kind of chitosan povidone-iodine solution of the present invention, raw material formula weight is by percentage, and its composition comprises:

[0026] Chitosan quaternary ammonium salt: 0.2%

[0027] Vinylpyrrolidone iodine: 1%

[0028] Potassium iodide: 0.1%

[0029] 0.1M citric acid monohydrate solution: 37.5%

[0030] 0.2M anhydrous disodium hydrogen phosphate solution: 61.2%.

Embodiment 2

[0032] A kind of chitosan povidone-iodine solution of the present invention, raw material formula weight is by percentage, and its composition comprises:

[0033] Chitosan quaternary ammonium salt: 1.3%

[0034] Vinylpyrrolidone iodine: 5%

[0035] Potassium iodide: 0.9%

[0036] 0.1M citric acid monohydrate solution: 56.8%

[0037] 0.2M anhydrous disodium hydrogen phosphate solution: 36%.

Embodiment 3

[0039] A kind of chitosan povidone-iodine solution of the present invention, raw material formula weight is by percentage, and its composition comprises:

[0040] Chitosan quaternary ammonium salt: 1%

[0041] Vinylpyrrolidone iodine: 5%

[0042] Potassium iodide: 0.5%

[0043] 0.1M citric acid monohydrate solution: 55%

[0044] 0.2M anhydrous disodium hydrogen phosphate solution: 38.5%.

[0045] The preparation method of the 0.1M citric acid monohydrate solution among the above three kinds of embodiments is: in the chitosan povidone iodine solution of every 100g, add purified water to 200g to 4.2g citric acid monohydrate. The preparation method of 0.2M anhydrous disodium hydrogen phosphate solution: add purified water to 5.68g anhydrous disodium hydrogen phosphate to 200g. And the active ingredient of chitosan povidone-iodine solution is available iodine, and the average value of available iodine content is 4.84g / L. The range of pH value of chitosan povidone-iodine solut...

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Abstract

The invention discloses a chitosan povidone-iodine solution and a manufacturing technologythereof. The raw material formula of the chitosan povidone-iodine solution comprises the following ingredients in percentage by weight: 0.2 to 1.3 percent of chitosan quaternary ammonium salt; 1 to 5 percent of vinylpynolidone; 0.1 to 0.9 percent of potassium iodide; 34 to 57.6 percent of 0.1M citric acid monohydrate solution; 36 to 61.2 percent of 0.2M anhydrous disodium hydrogen phosphate solution; the 0.1M citric acid monohydrate solution and the 0.2M anhydrous disodium hydrogen phosphate solution are both aqueous solutions prepared according to certain ratios. According to the chitosan povidone-iodine solution and the manufacturing technologythereof, the solution is simple in process, the product quality is excellent, no hazardous gas and liquid are discharged, and the product has the characteristics of being broad in spectrum, high in efficiency, long-acting, free of toxicity, stimulation and corrosiveness, and the like, and has good killing effects on bacteria, viruses and fungi.

Description

technical field [0001] The invention relates to the field of medical disinfectants, in particular to a formulation process of chitosan povidone-iodine solution. Background technique [0002] Chitosan (chitosan) is the only positively charged branched polysaccharide in nature. It has antibacterial, antitumor, immune enhancement and other functions. It has good biocompatibility and is non-irritating and non-toxic. Due to 2- In the presence of NH2, chitosan has a certain antibacterial function, but the antibacterial performance is limited, and it is affected by conditions such as chitosan molecular weight and deacetylation degree. After grafting quaternary ammonium salt on the molecular chain of chitosan, its antibacterial performance can be significantly improved. As a natural polycation, chitosan is easy to accumulate in the cell wall, preventing nutrients from entering the cell through the cell wall, causing cell failure and death; while low molecular chitosan [0003] Sug...

Claims

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Application Information

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IPC IPC(8): A61K31/79A61K31/722A61P31/04A61P31/10A61P31/12A01N59/12A01N43/16A01P1/00A01P3/00
CPCA01N43/16A01N59/12A61K9/08A61K31/722A61K31/79A61K47/02A61K47/12A61K2300/00A01N2300/00
Inventor 李一民
Owner 深圳市阳光百度生物科技发展有限公司
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