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Chondroitin sulfate injection and preparation method thereof

A technology of chondroitin sulfate and injection, which is applied in bone diseases, medical formulas, medical preparations of non-active ingredients, etc., can solve the problems of difficult preservation and low purity, and achieve easy preservation, simple preparation process and less impurities Effect

Inactive Publication Date: 2016-05-25
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its low purity, it is not easy to preserve, and there are certain limitations in the route of administration.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Prescription (percentage by weight): chondroitin sulfate 3%, ethylparaben 0.10%, water for injection 96.90%.

[0024] Preparation:

[0025] (1) Add water for injection into the batching tank and raise the temperature to 100°C;

[0026] (2) Add ethylparaben, stir to dissolve, then add chondroitin sulfate, stir to dissolve, boil, keep warm, and cool down to 73°C;

[0027] (3) Add activated carbon for needles, keep warm, circulate to make the liquid medicine uniform, filter it with a titanium rod while it is hot, put the liquid medicine into the dilute tank, add water for injection to the full amount, adjust the pH value to 6.2, and filter;

[0028] (4) Filtration, potting, steam sterilization, leak detection, light inspection, and packaging.

Embodiment 2

[0030] Prescription (percentage by weight): chondroitin sulfate 2.00%, ethylparaben 0.10%, water for injection 97.90%.

[0031] Preparation:

[0032] (1) Add water for injection into the batching tank and raise the temperature to 105°C;

[0033] (2) Add ethylparaben, stir to dissolve, then add chondroitin sulfate, stir to dissolve, boil, keep warm, and cool down to 77°C;

[0034] (3) Add activated carbon for needles, keep warm, circulate to make the liquid medicine uniform, filter it with a titanium rod while it is hot, put the liquid medicine into the dilute tank, add water for injection to the full amount, adjust the pH value to 6.0, and filter;

[0035] (4) Filtration, potting, steam sterilization, leak detection, light inspection, and packaging.

Embodiment 3

[0037] Prescription (weight percentage): chondroitin sulfate 5.00%, ethylparaben 0.01%, water for injection 94.90%.

[0038] Preparation:

[0039] (1) Add water for injection into the batching tank and raise the temperature to 95°C;

[0040] (2) Add ethylparaben, stir to dissolve, then add chondroitin sulfate, stir to dissolve, boil, keep warm, and cool down to 75°C;

[0041] (3) Add activated carbon for needles, keep warm, circulate to make the liquid medicine uniform, filter it with a titanium rod while it is hot, put the liquid medicine into the dilute tank, add water for injection to the full amount, adjust the pH value to 6.3, and filter;

[0042] (4) Filtration, potting, steam sterilization, leak detection, light inspection, and packaging.

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PUM

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Abstract

The present invention provides a chondroitin sulfate injection and a preparation method thereof, wherein the main active component of the chondroitin sulfate injection is chondroitin sulfate, and the components in the formula comprise, by weight, 0.01-5.00% of chondroitin sulfate, 0.01-0.10% of ethylparaben, and 94.90-99.09% of water for injection. According to the present invention, the chondroitin sulfate injection preparation process is simple, and the obtained chondroitin sulfate injection has characteristics of no toxic-side effect, storage within validity duration, and easy administration.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a chondroitin sulfate injection and a preparation method thereof. Background technique [0002] Chondroitin sulfate (Chondroitin Sulfate, CS) is one of the main components of mammalian connective tissue, mainly distributed in cartilage, bone, tendon, ligament, sarcolemma and blood vessel wall. The cartilage tissue of pigs, cattle, sheep and other animals and the cartilage of aquatic products such as sharks are used as raw materials, and are produced by biochemical extraction technology. Chondroitin Sulfate is used to treat neuralgia, migraine, arthralgia, cardiovascular and cerebrovascular diseases, hyperlipidemia, and also as an additive in food health products. It has a wide range of uses in medicine, cosmetics and food industries, and has a broad market prospect. [0003] At present, chondroitin sulfate preparations have been produced both at home and a...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/737A61K47/14A61P25/00A61P25/06A61P19/02A61P9/00A61P9/10A61P3/06A61P29/00
Inventor 曾培安吴健民贺莲张静刘娟
Owner KAMP PHARMA
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