Preparation method of drug carrier crosslinking-modified rice starch nanocrystals

A technology of starch nanocrystals and rice starch, which is applied in the field of starch deep processing, can solve the problems of limiting the application range and effect of starch microspheres, the control release ability needs to be strengthened, and the stability of drug loading needs to be improved, so as to achieve adjustable surface polarity, The effect of increasing drug loading and stability, and broad industrial application prospects

Inactive Publication Date: 2016-05-25
CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY
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Problems solved by technology

[0006] However, the existing starch microspheres still have defects in drug-loading performance: first, the stability of drug loading needs to be improved; second, the amount of drug carried is low; third, the ability to control release also needs to be strengthened
For these reasons, the application range and effect of starch microspheres are limited.

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] This embodiment includes the following steps:

[0019] (1) Preparation of starch nanocrystals: The prepared rice starch slurry (the rice starch slurry, the mass percentage of rice starch and water is 10%) was prepared by using a nano ultra-high pressure homogenizer under a homogeneous pressure of 207MPa. Homogenize at a rate of 30ml / min, freeze-dry the homogenized rice starch solution at -50°C for 3 days to obtain rice starch; In the flask, the mass of rice starch is 14.7% (g / ml) of the volume of the sulfuric acid solution. Put the flask into a constant temperature water bath at 40°C and keep a uniform stirring speed of 100r / min. After reacting the starch with sulfuric acid for 6 days, put The reaction product was repeatedly centrifuged and washed with deionized water until it was neutral, and freeze-dried at -50°C for 3 days to obtain rice starch nanocrystals;

[0020] (2) Ultrasonic dispersion of starch nanocrystals in the water phase: Mix the rice starch nanocrystal...

Embodiment 2

[0024] This embodiment includes the following steps:

[0025] (1) Preparation of starch nanocrystals: The prepared rice starch slurry (the rice starch slurry, the mass percentage of rice starch and water is 10%) was prepared by using a nano ultra-high pressure homogenizer. Homogenize at a mass rate of 35ml / min, then freeze-dry the homogenized rice starch solution at -50°C for 3 days to obtain rice starch; In a round bottom flask, the mass of rice starch is 14.7% (g / ml) of the volume of the sulfuric acid solution. Put the flask into a constant temperature water bath at 40°C and keep a uniform stirring speed of 100r / min; react the starch with sulfuric acid for 6 days , the reaction product was repeatedly centrifuged and washed with deionized water until it was neutral, and freeze-dried at -50°C for 1 day to obtain rice starch nanocrystals;

[0026] (2) Ultrasound fully disperses starch nanocrystals in the water phase: Mix rice starch nanocrystals and water obtained in step (1) ...

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Abstract

The invention relates to a preparation method of drug carrier crosslinking-modified rice starch nanocrystals. The method comprises the following steps: (1) preparing starch nanocrystals; (2) sufficiently dispersing the starch nanocrystals in a water phase under ultrasonic actions; and (3) preparing the crosslinking-modified starch nanocrystals. The starch nanocrystals are the restrictive acid hydrolysis product of starch, belong to organic nanoparticles, and can widen the application range of starch. A crosslinking reagent is utilized to carry out crosslinking modification on the rice starch nanocrystals to regulate and control the surface polarity of the starch nanocrystals, thereby increasing the hydrophobicity of the starch nanocrystals, enhancing the drug carrying capacity and stability of the nano starch particles, and lowering the enzymatic decomposability and digestibility of the starch nanocrystals. The method has the advantages of simple production technique and low cost, and has wide industrialized application prospects. The product has adjustable surface polarity, has the nano size, is biodegradable, and thus, is green and environment-friendly.

Description

technical field [0001] The invention relates to a method for preparing crosslinked modified starch nanocrystals used as a drug carrier, in particular to ultrasonic pretreatment technology and water phase starch nanocrystal crosslinking technology, and belongs to the field of starch deep processing. Background technique [0002] my country is the world's largest producer and consumer of rice. More than 65% of the country's population takes rice as a staple food. However, the loss rate of my country's grain storage is as high as 10%, which is about 9% higher than that of developed countries. The grain loss was as high as 24 million tons, which brought huge losses to the national finance and grain depots. Therefore, it is necessary to establish a grain conversion system as soon as possible to increase the utilization value and added value of grain and promote the sustainable development of grain production in our country. [0003] The main component of rice is starch (accountin...

Claims

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Application Information

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IPC IPC(8): C08B31/00A61K47/36
CPCA61K47/36C08B31/003
Inventor 肖华西林亲录王素燕白婕杨涛张琳许东丁玉琴卢锟杨英吴伟
Owner CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY
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