Preparation method of silicone rubber surface hydrophilic coating

A hydrophilic coating and silicone rubber technology, applied in the field of biomedical materials, can solve the problems of expensive oxygen plasma equipment and harsh operating conditions, and achieve the effects of simple process and equipment, easy promotion, and cheap and easy-to-obtain raw materials

Inactive Publication Date: 2016-05-25
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oxygen plasma equipment used in this method is relatively expensive and has harsh operating conditions

Method used

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  • Preparation method of silicone rubber surface hydrophilic coating
  • Preparation method of silicone rubber surface hydrophilic coating
  • Preparation method of silicone rubber surface hydrophilic coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step (1): 3-aminopropyltriethoxysilane (APTS) solution with a concentration of 1.5wt% is configured in an ethanol / water mixed solvent; the silicone rubber material is immersed in the above-mentioned APTS solution, stirred, and reacted for 1.5 hours, Take it out, rinse it with ethanol, and dry it to obtain a surface-aminated silicone rubber;

[0031] Step (2): polyethyleneimine and NaOH with a molecular weight of 1500 g / mol are dissolved in deionized water to obtain a solution, the concentration of polyethyleneimine in the solution is 30wt%, the concentration of NaOH is 1wt% of water, and the temperature of the solution is constant At 50°C; add epichlorohydrin to the above solution, so that the molar ratio of polyethyleneimine to epichlorohydrin is 5:1, stir immediately to make the solution evenly mixed; quickly mix the aminated silicone rubber obtained in step (1) Immerse in the above polyethyleneimine aqueous solution, react at 50°C for 4.5 hours, take it out, dry it n...

Embodiment 2

[0036] Step (1): Prepare a 2.5wt% 3-aminopropyltriethoxysilane (APTS) solution in an ethanol / water mixed solvent; immerse the silicone rubber material in the APTS solution, stir, and react for 1.5 hours. Take it out, rinse it with ethanol, and dry it to obtain a surface-aminated silicone rubber;

[0037] Step (2): polyethyleneimine and NaOH with a molecular weight of 3500 g / mol are dissolved in deionized water to obtain a solution, the concentration of polyethyleneimine in the solution is 17wt%, the concentration of NaOH is 1wt% of water, and the temperature of the solution is constant At 50°C; add epichlorohydrin to the above solution, so that the molar ratio of polyethyleneimine to epichlorohydrin is 9:1, stir immediately to make the solution evenly mixed; quickly mix the aminated silicone rubber obtained in step (1) Immerse in the above polyethyleneimine aqueous solution, react at 50°C for 4.5 hours, take it out, dry it naturally for 10 minutes, soak it with 2wt% sulfuric a...

Embodiment 3

[0040] Step (1): Prepare a 2wt% 3-aminopropyltriethoxysilane (APTS) solution in an ethanol / water mixed solvent; immerse the silicone rubber material in the APTS solution, stir, react for 1.5 hours, and take out , rinsed with ethanol, dried to obtain surface aminated silicone rubber;

[0041] Step (2): polyethyleneimine and NaOH with a molecular weight of 5200 g / mol are dissolved in deionized water to obtain a solution, the concentration of polyethyleneimine in the solution is 5wt%, the NaOH addition is 1wt% of water, and the solution temperature Constant at 50°C; add epichlorohydrin to the above solution, so that the molar ratio of polyethyleneimine to epichlorohydrin is 4.5:1, stir immediately to make the solution evenly mixed; quickly mix the silicon amide obtained in step (1) Immerse the rubber in the above polyethyleneimine aqueous solution, react at 50°C for 4.5 hours, take it out, dry it naturally for 10 minutes, soak it with 2wt% sulfuric acid aqueous solution at room t...

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Abstract

The invention relates to a preparation method of a silicone rubber surface hydrophilic coating. The preparation method comprises the following sequential steps: (1) immersing a silicone rubber material in a newly prepared silane coupling agent solution, and keeping reactions for 1.5 hours to obtain surface-aminated silicone rubber; (2) immersing the aminated silicone rubber in an aqueous solution of polyethyleneimine, adjusting the pH value of the solution by using NaOH, and adding epoxy chloropropane into the solution to obtain polyethyleneimine-grafted surface silicone rubber through chemical reactions; and (3) preparing an ethanol solution of polyvinylpyrrolidone, adding a photosensitizer, soaking the polyethyleneimine-grafted surface silicone rubber in the solution, taking out and naturally drying in a dark condition, and transferring into an ultraviolet curing device to receive ultraviolet irradiation to obtain a uniform hydrophilic coating with good lubricating property on the silicone rubber surface. The hydrophilic coating provided by the invention has good adhesion and biocompatibility and is particularly applicable to the field of biomedical materials.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, in particular to a method for modifying the surface of a silicone rubber base material with hydrophilic lubrication. Background technique [0002] The advantages of silicone rubber are non-toxic, good biocompatibility, high oxygen permeability, simple preparation method, low cost, softness and certain strength. The best candidate material for mirrors, endoluminal stents, etc. However, silicone rubber is a non-polar material with low surface energy, so its use in interventional medical devices is problematic. For example, the surface of PDMS is easy to adhere to non-polar substances. Bacteria can easily contaminate the surface of PDMS through adhesion proteins, and then form colonies, causing infection when left in the human body for a long time. When PDMS is used for long-term implantable medical devices, a large number of platelets adhere to the surface to cause thrombus, and even cause blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/388C08G77/442C08G77/452A61L29/06A61L29/08A61L29/14A61L31/06A61L31/10A61L31/14
CPCA61L29/06A61L29/085A61L29/14A61L31/06A61L31/10A61L31/14A61L2400/10A61L2420/06C08G77/388C08G77/442C08G77/452C08L83/04C08L79/02C08L39/06
Inventor 陶勇杨文君
Owner QINGDAO UNIV OF SCI & TECH
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