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A kind of easy peel film for medical packaging and preparation method thereof

A heat-sealing layer, ethylene technology, applied in the field of medical packaging materials, can solve the problems of easy migration into the packaging or adsorption by the packaging, the existence of drug safety risks, and the increase of film leaching substances, so as to reduce the treatment and drug safety risks. , to avoid particles and other pollution, the effect of low haze

Active Publication Date: 2018-07-24
湖北恒泰橡塑有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) Polypropylene (PP) as the main structure cannot meet the low temperature storage at less than -25°C and γ-ray irradiation sterilization, and it is easy to cause low temperature embrittlement and radiation cracking, which is not conducive to human health
[0006] (2) Polyethylene (PE) as the main structure cannot meet the technical requirements of high-temperature steam sterilization at 121-135°C for 30 minutes. Polyethylene (PE) has a low melting point and poor high-temperature resistance, and it is easy to shrink and burn after high-temperature steam sterilization. wrinkle
[0007] (3) Nylon (PA), polyethylene (PE) or polypropylene (PP) is used as the main structure, and nylon (PA) is used as the surface layer during high-temperature steam sterilization, and nylon (PA) is prone to whitening after absorbing water after sterilization. The light transmittance is low, the haze is large, and there is a risk of drug safety; when γ-rays are irradiated for sterilization, the amide bond in nylon (PA) is easily broken, resulting in browning of the surface of the membrane and an increase in the leached matter of the membrane, and these substances are easy to migrate Into the packaging or absorbed by the packaging

Method used

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  • A kind of easy peel film for medical packaging and preparation method thereof
  • A kind of easy peel film for medical packaging and preparation method thereof
  • A kind of easy peel film for medical packaging and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: A kind of raw material component of easy peel-off film of medical packaging (substance measurement unit is all by weight percentage):

[0036] (1) heat sealing layer: polyethylene 30%, ethylene-vinyl acetate 40%, ethylene-methyl acrylate 30%, the melt flow index (190 ℃, 2.16kg) of polyethylene in the described heat sealing layer is 0.5g / 10min, melting point 80~120℃, density 0.89g / cm 3 The melt flow index (190°C, 2.16kg) of ethylene-vinyl acetate in the heat-sealing layer is 0.5g / 10min, wherein the vinyl acetate content is 5%; the melt flow index of ethylene-methyl acrylate in the heat-sealing layer The melt flow index (190°C, 2.16kg) is 0.5g / 10min, wherein the methyl acrylate content is 10%;

[0037] (2) Structural layer: polyethylene, the melt flow index (190°C, 2.16kg) of the polyethylene is 0.3g / 10min, the melting point is 90°C, and the density is 0.89g / cm 3 ;

[0038] (3) Adhesive layer: maleic anhydride modified ethylene octene copolymer, the melt...

Embodiment 2

[0043] Embodiment 2: A kind of raw material component of medical packaging easy-to-remove film (substance measurement unit is all by weight percentage):

[0044] (1) heat sealing layer: polyethylene 80%, ethylene-vinyl acetate 10%, ethylene-methyl acrylate 10%, the melt flow index (190 ℃, 2.16kg) of polyethylene in the heat sealing layer is 10g / 10min , with a melting point of 120°C and a density of 0.94g / cm 3 The melt flow index (190°C, 2.16kg) of ethylene-vinyl acetate in the heat-sealing layer is 5g / 10min, wherein the vinyl acetate content is 30%; the melt flow index of ethylene-methyl acrylate in the heat-sealing layer Body flow index (190°C, 2.16kg) is 10g / 10min, and the content of methyl acrylate is 35%;

[0045] (2) Structural layer: polyethylene, the melt flow index (190°C, 2.16kg) of the polyethylene is 8g / 10min, the melting point is 125°C, and the density is 0.96g / cm 3 ;

[0046] (3) Adhesive layer: maleic anhydride modified ethylene octene copolymer, the melt flow...

Embodiment 3

[0051] Embodiment 3: A kind of raw material component of easy peel-off film of medical packaging (substance measurement unit is all by weight percentage):

[0052] (1) heat sealing layer: polyethylene 50%, ethylene-vinyl acetate 30%, ethylene-methyl acrylate 20%, the melt flow index (190 ℃, 2.16kg) of polyethylene in the heat sealing layer is 8g / 10min , with a melting point of 80-120°C and a density of 0.9g / cm 3 The melt flow index (190°C, 2.16kg) of ethylene-vinyl acetate in the heat-sealing layer is 3g / 10min, wherein the vinyl acetate content is 20%; the melt flow index of ethylene-methyl acrylate in the heat-sealing layer The body flow index (190°C, 2.16kg) is 5g / 10min, and the content of methyl acrylate is 20%;

[0053] (2) Structural layer: polyethylene, the melt flow index (190°C, 2.16kg) of the polyethylene is 5g / 10min, the melting point is 100°C, and the density is 0.91g / cm 3 ;

[0054] (3) Adhesive layer: maleic anhydride modified ethylene octene copolymer, the mel...

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Abstract

The invention discloses a medical packing easy-to-tear-off film and a preparation method thereof. The medical packing easy-to-tear-off film comprises four layers of structures from inside to outside: a thermal bonding layer, a structural layer, an adhesive layer and an outer layer, wherein the thermal bonding layer is prepared from mixed resin consisting of medical-level polyethylene, ethylene-vinyl acetate and ethylene-methyl acrylate; the structural layer is prepared from medical-level polyethylene; the adhesive layer is prepared from maleic anhydride modified ethylene-octene copolymer; the outer layer is prepared from a polyester elastomer. The medical packing easy-to-tear-off film disclosed by the invention can realize sterilization using high-temperature steam at 121 to 135 DEG C or gamma-ray irradiation, and can be stored under the temperature lower than minus 25 DEG C. Furthermore, the film is good in transparency, less in migration separates and good in medicament compatibility, is extremely high in easy-to-tear-off property, and can meet the performance requirement on medical packing, so that the convenience and the safety of medicament taking by a patient are improved.

Description

technical field [0001] The invention relates to the technical field of medical packaging materials, and more specifically refers to an easy-to-release film for medical packaging and a preparation method thereof. Background technique [0002] Medical packaging films have great market potential, and pharmaceuticals and medical devices have high requirements for packaging films. They not only need to ensure the flexibility, barrier properties, and transparency of the film, but also consider ensuring that they are safe in the sterilization and storage environment. The content is stable, and no toxic and harmful substances will be migrated and adsorbed to affect the safety performance. Based on this, people are actively researching various new packaging materials for pharmaceutical and medical device packaging to meet the demanding requirements of medical packaging in all aspects and at multiple levels. [0003] In the past, people often found that the product packaging bag was ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B32B27/08B32B27/32B32B27/36B32B27/30
CPCB32B27/08B32B27/306B32B27/32B32B27/36B32B2250/03B32B2307/306B32B2307/31B32B2307/412B32B2307/546B32B2439/80
Inventor 王光华程立坤刘子明徐小明
Owner 湖北恒泰橡塑有限公司
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