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Preparation method of high-sensitivity functionalized gold nanoparticle-doped phenprobamate MIECS (Molecular Imprinting Electrochemical Sensor)

A gold nanoparticle and phenylalanine technology, which is applied in the fields of material electrochemical variables, scientific instruments, instruments, etc., can solve the problems that functional monomers and template molecules cannot be properly matched, poor cross-linking rigidity, and low sensitivity, etc. Achieve excellent sensitivity, simple production and simple equipment

Inactive Publication Date: 2016-06-01
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be properly matched with the template molecules, and the rigidity of the cross-linking is also poor.

Method used

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  • Preparation method of high-sensitivity functionalized gold nanoparticle-doped phenprobamate MIECS (Molecular Imprinting Electrochemical Sensor)

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Experimental program
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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in turn, then put it into nitric acid with a volume ratio of 1:1 for 8 minutes, then put it into absolute ethanol for 8 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of phenylalanine molecularly imprinted electrochemical sensor

[0017] To 10.0mL solvent ethanol, add 0.4mmol template molecule phenylalanine, 2.0mmol functional monomer aminotadalafil, 5mmol crosslinking agent hydrocortisone acetate, 0.2mmol initiator azodiiso Butyronitrile and 0.0350g of dodecyl mercaptan functionalized gold nanoparticles are ultrasonically dissolved for 9 minutes each time a chemical reagent is added;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode with a diameter of 2 mm. The template molecules were eluted with a mixed solvent o...

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Abstract

The invention discloses a preparation method of a high-sensitivity functionalized gold nanoparticle-doped phenprobamate MIECS (Molecular Imprinting Electrochemical Sensor). The preparation method is characterized by taking phenprobamate as a template molecule, aminotadalafil as a functional monomer, azodiisobutyronitrile as an initiator, dodecanethiol functionalized gold nanoparticles as a doping agent and hydrocortisone acetate as a coupling agent, thus preparing the high-sensitivity dodecanethiol functionalized gold nanoparticle-doped phenprobamate MIECS. An analysis method is simple and practical, and the disadvantages of complexity, expensive price of equipment and low sensitivity of a previous analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a method for preparing a high-sensitivity functionalized gold nanoparticle-doped phenylalanine molecularly imprinted electrochemical sensor. Background technique [0002] The main function of phenylalanine is to treat pain caused by abnormal muscle tension such as anxiety, muscle spasms, and muscle rigidity. However, excessive use of such drugs can cause drowsiness, dizziness, general fatigue, unsteady walking, nausea, and bloating , abdominal pain, stomach discomfort and stomach dull pain and other side effects. [0003] The methods for determining phenylalanine (Phenprobamate) include ultraviolet spectroscopy, high performance liquid chromatography gradient elution method, reversed-phase high performance liquid chromatography-diode array method, etc. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high ...

Claims

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Application Information

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IPC IPC(8): G01N27/48G01N27/30
CPCG01N27/308G01N27/48
Inventor 韦贻春余会成李浩雷福厚陈其锋谭学才
Owner GUANGXI UNIV FOR NATITIES
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