Preparation method of high-sensitivity functionalized gold nanoparticle-doped phenprobamate MIECS (Molecular Imprinting Electrochemical Sensor)

A gold nanoparticle and phenylalanine technology, which is applied in the fields of material electrochemical variables, scientific instruments, instruments, etc., can solve the problems that functional monomers and template molecules cannot be properly matched, poor cross-linking rigidity, and low sensitivity, etc. Achieve excellent sensitivity, simple production and simple equipment

Inactive Publication Date: 2016-06-01
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be prope

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  • Preparation method of high-sensitivity functionalized gold nanoparticle-doped phenprobamate MIECS (Molecular Imprinting Electrochemical Sensor)

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[0013] Example 1

[0014] 1. Treatment of glassy carbon electrode

[0015] Polish the glassy carbon electrode on the polishing cloth with 1.0μm, 0.3μm and 0.05μm alumina powder, then put it in nitric acid with a volume ratio of 1:1 and sonicate for 8min, then put it in absolute ethanol for 8min, and finally Ultrasonic clean with pure water.

[0016] 2. Preparation of phenylalanine molecularly imprinted electrochemical sensor

[0017] To 10.0mL solvent ethanol, add 0.4mmol template molecule phenylalanine, 2.0mmol functional monomer amino tadanafil, 5mmol crosslinker hydrocortisone acetate, 0.2mmol initiator azobisisobutyronitrile and 0.0350g dodecanethiol-functionalized gold nanoparticles are dissolved in ultrasonic for 9 minutes each time a chemical reagent is added;

[0018] Take steps Apply 8μL of the mixture on the surface of a clean and smooth glassy carbon electrode with a diameter of 2mm. After standing for 5 hours, place the modified electrode in a vacuum drying oven at 68°C...

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Abstract

The invention discloses a preparation method of a high-sensitivity functionalized gold nanoparticle-doped phenprobamate MIECS (Molecular Imprinting Electrochemical Sensor). The preparation method is characterized by taking phenprobamate as a template molecule, aminotadalafil as a functional monomer, azodiisobutyronitrile as an initiator, dodecanethiol functionalized gold nanoparticles as a doping agent and hydrocortisone acetate as a coupling agent, thus preparing the high-sensitivity dodecanethiol functionalized gold nanoparticle-doped phenprobamate MIECS. An analysis method is simple and practical, and the disadvantages of complexity, expensive price of equipment and low sensitivity of a previous analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a method for preparing a high-sensitivity functionalized gold nanoparticle-doped phenylalanine molecularly imprinted electrochemical sensor. Background technique [0002] The main function of phenylalanine is to treat pain caused by abnormal muscle tension such as anxiety, muscle spasms, and muscle rigidity. However, excessive use of such drugs can cause drowsiness, dizziness, general fatigue, unsteady walking, nausea, and bloating , abdominal pain, stomach discomfort and stomach dull pain and other side effects. [0003] The methods for determining phenylalanine (Phenprobamate) include ultraviolet spectroscopy, high performance liquid chromatography gradient elution method, reversed-phase high performance liquid chromatography-diode array method, etc. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high ...

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Application Information

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IPC IPC(8): G01N27/48G01N27/30
CPCG01N27/308G01N27/48
Inventor 韦贻春余会成李浩雷福厚陈其锋谭学才
Owner GUANGXI UNIV FOR NATITIES
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