Stable ixabepilone pharmaceutical composition
A technology of ixabepilone and composition, applied in the field of ixabepilone pharmaceutical composition and its preparation
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Embodiment 1
[0033] The formulation of ixabepilone made into 1000 tablets is as follows:
[0034] Ixabepilone 15g
[0035] Croscarmellose Sodium 50g
[0036] Microcrystalline cellulose 70g
[0037] Micropowder silica gel 0.5g
[0038] Appropriate amount of 10% pregelatinized starch solution
[0039] Preparation
[0040] 1) Ixabepilone, croscarmellose sodium and microcrystalline cellulose were dried, pulverized, and passed through a 100-mesh sieve to obtain ixabepilone powder, croscarmellose sodium and microcrystalline cellulose respectively. Cellulose powder;
[0041] 2) Take the prescribed amount of ixabepilone, croscarmellose sodium and microcrystalline cellulose, mix well, then add 10% pregelatinized starch solution to make a soft material, pass through a 40-mesh sieve to granulate , to obtain ixabepilone wet granules;
[0042] 3) Dry the above-mentioned ixabepilone wet granules at 60°C until the water content is less than 5%, to obtain ixabepilone dry granules
[0043] 4) Pass ...
Embodiment 2
[0045] The formulation of ixabepilone made into 1000 tablets is as follows:
[0046] Ixabepilone 45g
[0047] Croscarmellose Sodium 100g
[0048] Microcrystalline cellulose 140g
[0049] Micropowder silica gel 1g
[0050] Appropriate amount of 10% pregelatinized starch solution
[0051] Preparation
[0052] 1) Ixabepilone, croscarmellose sodium and microcrystalline cellulose were dried, pulverized, and passed through a 100-mesh sieve to obtain ixabepilone powder and microcrystalline cellulose powder respectively;
[0053] 2) Take the prescribed amount of ixabepilone, croscarmellose sodium and microcrystalline cellulose, mix well, then add 10% pregelatinized starch solution to make a soft material, pass through a 40-mesh sieve to granulate , to obtain ixabepilone wet granules;
[0054] 3) drying the above-mentioned ixabepilone wet granules at 60°C until the water content is less than 5%, to obtain ixabepilone dry granules;
[0055] 4) Pass the above-mentioned dry ixabepi...
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