A method for extracting high-purity solanesol from tobacco leaves
A solanesol, high-purity technology, applied in the field of extraction of solanesol, can solve the problems of unfavorable comprehensive utilization, pollution of the environment, waste of water and electricity, etc., and achieve the effect of low cost, small environmental pollution and high adsorption activity
Active Publication Date: 2018-08-17
HEXI UNIV
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Problems solved by technology
The main source of fly ash is thermal power plants and urban central heating boilers that use pulverized coal as fuel, of which more than 90% are wet ash, which has lower activity than dry ash, and consumes water and electricity, pollutes the environment, and is not conducive to comprehensive use
Method used
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Experimental program
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Effect test
Embodiment Construction
[0014] The extraction method and purification effect of solanesol of the present invention will be further described through specific examples below.
[0015] (1) Treatment of fly ash: Take a certain amount of fly ash, mix it with 2mol / L sodium hydroxide solution at a solid-to-liquid ratio of 1 / 3 (unit: g / L), and heat it in a water bath at 50°C for 3 hours; Move it into a high-pressure reactor, boil it at about 100°C for 12 hours, filter it with suction after cooling, dry it and react it in a muffle furnace at 850°C for 8 hours, cool it, wash it with deionized water until it is neutral, and then wash it with absolute ethanol and petroleum ether in sequence. Wash and dry to obtain the fly ash product (PLT-C) for later use.
[0016] (2) Extraction of crude solanesol: Take 50 g of dried and pulverized tobacco leaves, and use anhydrous methanol to reflux extract 3 times according to the solid-to-liquid ratio of 1 / 8, 1 / 4 and 1 / 3 respectively, and the extraction time for each time i...
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Abstract
The invention aims at providing a method for extracting high-purity solanesol from tobacco leaves, and belongs to the technical field of extracting and purifying of effective plant components. The method includes the steps that the tobacco leaves serve as raw materials, and are subjected to alcohol extraction, extracted, separated and concentrated to obtain a black-brown viscous solanesol crude product, then processed coal ash serves as an adsorbing material for column chromatography separation, and the high-purity solanesol product is obtained. As abundant microcellular structures are formed in the surface of the processed coal ash, adsorption activity is high; physical absorption can be carried out according to interaction force and the huge specific surface area between the microcellular structures and adsorbed molecules (adsorbate), organic compounds are eluted and separated through a certain solvent according to the polarity and the molecular weight, and therefore the solanesol in the tobacco-leaf solanesol crude product is separated and purified. Liquid chromatogram detection shows that the purity of the solanesol product prepared with the method is 95% or above. In addition, the method has the advantages of being simple in technology, small in organic-solvent dosage, low in cost and small in environment pollution.
Description
technical field [0001] The invention relates to a method for extracting solanesol, in particular to a method for extracting high-purity solanesol from tobacco leaves, and belongs to the technical field of extraction and purification of plant active ingredients. Background technique [0002] Solanesol is an important pharmaceutical intermediate, an irreplaceable component of ubiquinone drug intermediates, and an irreplaceable natural raw material for the synthesis of the side chain of vitamin K and coenzyme Q10, as well as the synthesis of anti-ulcer drugs and anti-cancer drugs. Solanesol is an unsaturated nonaprenyl alcohol, which mainly exists in Solanaceae plants, among which the content of solanesol in tobacco leaves is the highest. Crude solanesol cannot be directly used as a medicinal raw material. [0003] CN200510124541.6 discloses a method for extracting high-purity solanesol from potato leaves, which mainly includes using a solvent to obtain an extract of potato le...
Claims
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IPC IPC(8): C07C33/02C07C29/76
CPCC07C29/76C07C33/02
Inventor 金淑萍陈宏旺邸多隆
Owner HEXI UNIV