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Amphipathic high-molecular polymer, and preparation method and application thereof

An amphiphilic polymer and polymer technology, which is applied in the field of amphiphilic polymer and its preparation, can solve the problems of many types of chemical reagents, complicated operation steps, inconvenient operation, etc., and achieves low cytotoxicity and low cost. Inexpensive and easy to operate

Inactive Publication Date: 2016-06-08
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the operation steps are generally more complicated, the reaction route is long, and the types of chemical reagents required are large, the operation is inconvenient, and the cost is high.

Method used

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  • Amphipathic high-molecular polymer, and preparation method and application thereof
  • Amphipathic high-molecular polymer, and preparation method and application thereof
  • Amphipathic high-molecular polymer, and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0039] The synthetic method of polylactic acid-glycolic acid-polyethyleneimine (PEI-PLGA) amphiphilic polymer: Polylactic acid-glycolic acid (PLGA, Mw is about 80,000) is dissolved in anhydrous tetrahydrofuran and added to polyethylene In the isopropanol solution of imine (PEI, Mw about 2000), the two are mixed according to the repeating unit lactic acid (or glycolic acid): ethyleneimine molar ratio of 20:1, and react at a constant temperature of 60°C for 5 minutes to obtain The polymer solution was dialyzed in water, and unreacted small molecules were removed by dialysis with a dialysis membrane with a molecular weight cut-off of 10,000. After lyophilization, a white solid product was obtained for subsequent detection and characterization. figure 1 Be the XPS spectrogram of PEI-PLGA of the present embodiment and PLGA, by figure 1 It can be seen that the appearance of the N peak in the PEI-PLGA polymer is due to the introduction of PEI into the polylactic acid-glycolic acid (P...

Embodiment 2

[0042] The reaction was performed at a constant temperature of 60° C. for 10 minutes, and the other operating steps were the same as in Example 1.

Embodiment 3

[0044] The reaction was performed at a constant temperature of 60° C. for 20 minutes, and the other operating steps were the same as in Example 1.

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Abstract

The invention provides an amphipathic high-molecular polymer, and a preparation method and application thereof. The method comprises the following steps: dissolving a polymer matrix to be modified in an organic solvent, adding an alcoholic solution of a hydrophilic modified material, carrying out thermostatic reaction at 40-80 DEG C for 5-60 minutes to obtain a polymer solution, dialyzing in water, and carrying out freeze-drying, wherein the polymer matrix to be modified comprises one of polylactic acid, polylactic acid copolymer, polyhydroxycarboxylic acid polymer and polyester polymer, and the hydrophilic modified material comprises one of polyethyleneglycol, polypolypeptide, polyethyleneimine, chitosan and polyamine polymer. The one-step method can be used for modifying the polymer molecules without using the toxic heavy metal compound as a catalyst; and thus, the method is simple, and is low in cost. The amphipathic high-molecular polymer has wide application prospects in the aspects of low-cytotoxicity nano microspheres, biological material surface modification and biological drug carrying.

Description

technical field [0001] The invention relates to the field of polymer material preparation, in particular to an amphiphilic polymer and its preparation method and application. Background technique [0002] Due to its unique molecules, amphiphilic polymers can self-assemble into various forms of macromolecules, such as micelles, microspheres, liquid crystals, and vesicles. These structural aggregates have the ability to coat drug molecules and have excellent membrane permeability, which has attracted more and more attention in the research field of drug carriers. With the application of structure-controllable polymer synthesis technology, the structure of amphiphilic polymers has been greatly enriched, and polymer aggregates have been endowed with various functionalities including targeting, temperature, and pH sensitivity, further enriching their in-situ applications. Range of applications in the field of drug delivery. [0003] Amphiphilic degradable polymers have the dual...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00A61K9/16A61K47/34A61K47/42A61L27/18A61L27/22
CPCA61K9/1641A61K9/1658A61L27/18A61L27/22C08G81/00C08L87/00C08L89/00
Inventor 陈学琴江兵兵
Owner HUBEI UNIV
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