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Antifungal product of ambroxol hydrochloride combined with fluconazole and its application

A technology of ambroxol hydrochloride and fluconazole, applied in the field of medicine, can solve problems such as drug resistance, and achieve the effects of large application amount, reducing the minimum effective bacteriostatic concentration, and expanding the scope of application

Active Publication Date: 2018-06-29
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide an antifungal product of ambroxol hydrochloride combined with fluconazole and its application in order to overcome the current problem of fungal drug resistance

Method used

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  • Antifungal product of ambroxol hydrochloride combined with fluconazole and its application
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  • Antifungal product of ambroxol hydrochloride combined with fluconazole and its application

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Embodiment Construction

[0030] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0031] Embodiment Ambroxol hydrochloride and fluconazole combined antifungal action determination

[0032] 1. Materials

[0033] 1.1 Drugs and reagents

[0034] Fluconazole (FLC), Dalian Meilun Biotechnology Co., Ltd.;

[0035] Ambroxol hydrochloride (Ambroxol hydrochloride, ABH), Dalian Meilun Biotechnology Co., Ltd.;

[0036] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0037] TTC-Sa Paul medium, Qingdao Hi-tech Park Haibo Biotechnology Co., Ltd.;

[0038] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0039] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0040] Glucose, Sinopharm Chemical Reagent Co., Ltd.;

[0041] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0042] PBS phosphate buffer, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0043] Sodium hydr...

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Abstract

The invention discloses an antifungal product combining ambroxol hydrochloride with fluconazole and application thereof and belongs to the technical field of medicine. Static and dynamic combined antifungal effect, on medicine-resistant Candida albicans, of combined use of fluconazole and ambroxol hydrochloride is studied through various methods. An effective concentration proportion of fluconazole to ambroxol hydrochloride when ambroxol hydrochloride and fluconazole are combined for application is 1:64 (ug / mL), and lowest antibacterial concentrations are 128 ug / mL and 2 ug / mL respectively. When ambroxol hydrochloride is combined with fluconazole, antibacterial activity, to medicine-resistant Candida albicans, of fluconazole can be improved, synergistic antifungal effect can be generated, medicine resistance, to fluconazole, of medicine-resistant Candida albicans can be reversed, and a studying direction is provided for development of new drugs and new application of old drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an antifungal product of ambroxol hydrochloride combined with fluconazole and an application thereof. Background technique [0002] In recent years, with the increase of patients with acquired immunodeficiency syndrome (AIDS) and the wide application of broad-spectrum antibacterial drugs, the development of medical technologies such as organ transplantation technology and catheter technology, the incidence and mortality of invasive fungal infections have increased year by year , especially for infections caused by Aspergillus and Candida, the survival rates of patients are less than 30% and 70%, respectively. Although the clinical threat of Candida infection is not as great as that caused by Aspergillus infection, due to the enhanced drug efflux and gene target changes (such as ERG11) in this type of fungus, Candida sensitive to azole antifungal drugs Bacteria continue to devel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61P31/10A61K31/137
CPCA61K31/137A61K31/4196A61K2300/00
Inventor 孙淑娟李秀云张才擎韩毅崔学艳
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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